Citation: Yingqiang Liang, Shilun Li, Yixiao Pan, Weiyu Zhang, Shupeng Liu, Yiwen Chen, Jiangfeng Hu, Xueliang Zhang, Jun Zhao, Zhigang Zheng. Exosome-hybridized hydrogel acts as a foamy protective coat for the liver[J]. Chinese Chemical Letters, ;2025, 36(11): 110841. doi: 10.1016/j.cclet.2025.110841 shu

Exosome-hybridized hydrogel acts as a foamy protective coat for the liver

Yingqiang Liang ^{a, 1} ,
Shilun Li ^{b, 1} ,
Yixiao Pan ^{c, 1} ,
Weiyu Zhang ^{d, 1} ,
Shupeng Liu ^e ,
Yiwen Chen ^f ,
Jiangfeng Hu ^{g, *,} ,
Xueliang Zhang ^{h, *,} ,
Jun Zhao ^{a, *,} ,
Zhigang Zheng ^{i, *,}

a.
Department of Special Medical Care, Third Affiliated Hospital of Naval Medical University, Shanghai 200438, China
b.
Department of Vascular Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
c.
Department of Liver Surgery and Liver Transplantation, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
d.
Cancer institute, University College of London, London, WC1E 6BT, United Kingdom
e.
Department of Gastroenterology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
f.
Department of Gastrointestinal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
g.
Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China
h.
School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
i.
Department of Interventional Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China

doctorhjf@foxmail.com

XLZhang2020@sjtu.edu.cn

1239635303@qq.com

17352929252@163.com

Received Date: 8 October 2024
Revised Date: 9 January 2025
Accepted Date: 9 January 2025
Available Online: 11 January 2025

Figures(3)

Currently, various clinical treatment methods struggle to halt the rapid progression of common acute liver failure. To address this issue, significant advancements in stem cell derivatives and bioactive hydrogels in regenerative medicine have been utilized. A bioactive hydrogel with good tissue adhesion, CCO/HGF@EV, has been designed by incorporating cytokine hepatocyte growth factor (HGF), which plays a major role in the early regenerative phase of the liver, into stem cell-derived exosomal vesicles (EV) through electroporation. Under ultrasonic guidance, CCO/HGF@EV is administered near the liver, adhering firmly and degrading over three days to release HGF@EV. Through a series of rigorous experiments, it was confirmed that the abundant anti-inflammatory and regenerative cytokines in HGF@EV significantly reduced reactive oxygen species (ROS) during the acute phase of liver failure, alleviated hepatocyte apoptosis, decreased inflammatory damage and necrosis of liver tissue, and significantly promoted the regeneration and repair of liver parenchymal cells and vascular tissues. Additionally, the release of HGF after EV fusion with hepatocytes synergistically enhanced the regeneration of liver cells during the acute phase, thereby stabilizing liver function. This hydrogel, with its powerful therapeutic effects, forms a protective layer over the liver. It holds great potential for advancing research in tissue engineering and regenerative medicine and has significant clinical translational value.
- Hydrogel,
- EV,
- HGF,
- Acute liver failure,
- Stem cell
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