Citation: Lijun Li, Chenliang Guo, Yuelin Fang, Zijian Cheng, Yaowei Li, Zhangyu Wang, Dian Cai, Yuqi Xu, Wenqi Liu, Shouwei Ma, Xinxin Zhang. Deformable hyaluronic acid niosomes overcome multi-barriers for improved ergothioneine transdermal delivery against UV-induced skin damage[J]. Chinese Chemical Letters, ;2025, 36(11): 110839. doi: 10.1016/j.cclet.2025.110839 shu

Deformable hyaluronic acid niosomes overcome multi-barriers for improved ergothioneine transdermal delivery against UV-induced skin damage

Lijun Li ^{a, b, 1} ,
Chenliang Guo ^{d, 1} ,
Yuelin Fang ^c ,
Zijian Cheng ^{a, b} ,
Yaowei Li ^e ,
Zhangyu Wang ^{a, b} ,
Dian Cai ^{a, b} ,
Yuqi Xu ^{a, b} ,
Wenqi Liu ^c ,
Shouwei Ma ^{d, *,} ,
Xinxin Zhang ^{a, b, c, e, *,}

a.
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
b.
University of Chinese Academy of Sciences, Beijing 100049, China
c.
Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, China
d.
Bloomage Biotechnology Corporation Limited, Shanghai 201304, China
e.
School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China

mashouwei306@163.com

xinxinzhang@simm.ac.cn

Received Date: 13 November 2024
Revised Date: 5 January 2025
Accepted Date: 9 January 2025
Available Online: 9 January 2025

Figures(6)

The complex skin structure and insufficient intracellular entrapment limit the therapeutic effects of active substances, therefore appealing to a more effective transdermal drug delivery system design. Herein, a hyaluronic acid (HA) modified steareth-2-based niosomes (HA-nio) with satisfactory deformability and targeting properties was designed for ergothioneine (EGT) (EGT@HA-nio) against ultraviolet (UV)-induced skin damage. The unique composition allows EGT@HA-nio to exhibit high mechanical softness, making it deformable to pass through the stratum corneum by the intercellular space without rupture. For further intracellular delivery, HA modification enables EGT to target human dermal cells (HDFs) with increased distribution in mitochondria without the restriction of specific EGT transporter-organic cation transporter 1 (OCTN-1). Benefiting from the above properties, an adequate amount of EGT in the active form was accumulated in the desired cellular sites, alleviating UV-radiation-induced reactive oxygen species (ROS) generation, inflammatory factor release, DNA damage, and mitochondrial dysfunction. The in vivo experimental results show that EGT@HA-nio could significantly decrease collagen degradation, restore epidermal thickness and morphology to healthy levels, and effectively prevent UV-induced skin damage. With the ability to penetrate biological barriers and deliver drugs, HA-nio may promote the development of inadequate drug penetration disease treatment including skin diseases, cancers, and bacterial infections.
- Transdermal delivery,
- Ergothioneine,
- Deformability,
- Niosomes,
- UV-induced skin damage
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