Citation: Yuliang Yang, Jingyi Zhang, Yu Wang, Huan Chen, Yijian Gao, Xiliang Li, Yingpeng Wan, Qi Zhao, Ning Li, Shengliang Li. Quintuple-acceptor engineering of anti-quenching conjugated oligomers for highly efficient NIR-Ⅱb imaging and phototheranostics[J]. Chinese Chemical Letters, ;2025, 36(11): 110834. doi: 10.1016/j.cclet.2025.110834 shu

Quintuple-acceptor engineering of anti-quenching conjugated oligomers for highly efficient NIR-Ⅱb imaging and phototheranostics

Yuliang Yang ^{a, 1} ,
Jingyi Zhang ^{b, 1} ,
Yu Wang ^{a, *,} ,
Huan Chen ^a ,
Yijian Gao ^a ,
Xiliang Li ^a ,
Yingpeng Wan ^a ,
Qi Zhao ^a ,
Ning Li ^{a, *,} ,
Shengliang Li ^{a, *,}

a.
College of Pharmaceutical Sciences, Fourth Affiliated Hospital of Soochow University, Suzhou Medical College, Soochow University, Suzhou 215123, China
b.
Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang 110801, China

yuwang@suda.edu.cn

lining1991@suda.edu.cn

lishengliang@suda.edu.cn

Received Date: 23 October 2024
Revised Date: 2 January 2025
Accepted Date: 6 January 2025
Available Online: 7 January 2025

Figures(7)

Near-infrared (NIR) theranostics have received considerable attention because of their advantages in precise diagnostic imaging and efficient simultaneous treatment and have achieved tremendous advancements in the last few years. However, their progress is severely restricted by the rarity of efficient second NIR (NIR-Ⅱ) responsive phototheranostic materials, especially in the NIR-Ⅱb region. Moreover, these materials often embarrass the quenching puzzle in the aggregative state, thus greatly reducing their theranostic performance. To overcome this limitation, we developed anti-quenching donor-acceptor-donor (D-A-D)-conjugated oligomers with NIR-Ⅱb emission for high-performance NIR-Ⅱ angiography and phototheranostics. Through multi-acceptor engineering, a series of multi-acceptor conjugated oligomer SU-n (n = 1, 2, and 5) with tunable acceptor ratios were synthesized, and their efficiency in anti-quenching NIR-Ⅱ emission was demonstrated. When prepared into water-dispersed nanoparticles (NPs), SU-5 NPs exhibit bright NIR-Ⅱ emission and dual phototherapy for photothermal therapy and photodynamic therapy simultaneously upon 808 nm light excitation. With these benefits, high-resolution whole-body and local angiography in vivo of SU-5 NPs were successfully realized in the NIR-Ⅱb window. Moreover, in vivo, theranostics experiments demonstrated the efficiency of SU-5 NPs in NIR-Ⅱ imaging-guided complete tumor photoablation without any relapses with high biosafety. This work explores a practical multi-acceptor engineering strategy for developing anti-quenching theranostic materials, providing an efficient theranostic agent for efficient NIR-Ⅱb bioimaging and phototheranostics.
- Conjugated oligomer,
- Photothermal therapy,
- Photodynamic therapy,
- Donor-acceptor,
- NIR
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