Citation: Xiaosheng Zhao, Jie Gao, Kun Shi, Chixiang Zhang, Wenliang Ma, Guo Lyu, Jun Zhang, Jing Lu, Qiangqiang Liu, Xianjin Luo, Kunru Yu, Jianguo Li, Qiang Ge, Jiming Cai, Chang Liu, Zhiyong Qian. A new radioactive microsphere: Y-90 carbon microsphere for selective internal radiation therapy of advanced liver cancer[J]. Chinese Chemical Letters, ;2025, 36(8): 110662. doi: 10.1016/j.cclet.2024.110662 shu

A new radioactive microsphere: Y-90 carbon microsphere for selective internal radiation therapy of advanced liver cancer

Xiaosheng Zhao ^{a, c} ,
Jie Gao ^d ,
Kun Shi ^a ,
Chixiang Zhang ^c ,
Wenliang Ma ^c ,
Guo Lyu ^c ,
Jun Zhang ^c ,
Jing Lu ^c ,
Qiangqiang Liu ^c ,
Xianjin Luo ^c ,
Kunru Yu ^c ,
Jianguo Li ^d ,
Qiang Ge ^c ,
Jiming Cai ^c ,
Chang Liu ^{b, *,} ,
Zhiyong Qian ^{a, *,}

a.
Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
b.
Liver Transplant Center, Transplant Center, West China Hospital, Sichuan University, Chengdu 610041, China
c.
Chengdu New Radiomedicine Technology Co., Ltd., Chengdu 610200, China
d.
National Atomic Energy Agency Nuclear Technology (Nonclinical evaluation of radiopharmaceuticals) Research and Development Center, China Institute for Radiation Protection, Taiyuan 030006, China

drliuchang@wchscu.cn

anderson-qian@163.com

Received Date: 8 March 2024
Revised Date: 16 November 2024
Accepted Date: 20 November 2024
Available Online: 22 November 2024

Figures(5)

Radioactive microspheres have demonstrated excellent therapeutic effects and good tolerance in the treatment of unresectable primary and secondary liver malignancies. This is attributed to precise embolization and potent anti-tumor effect. However, certain limitations such as unstable loading, perfusion stasis, heterogeneous distribution, ectopic distribution, and insufficient dosage, restrict their clinical application. Herein, a novel personalized Y-90 carbon microsphere with high uniformity, high specific activity and high availability (⁹⁰Y-HUACM) is presented. It is synthesized through planar molecular complex adsorption and chemical deposition solidification. ⁹⁰Y-HUACM exhibited controllable size, excellent biocompatibility, outstanding in vitro and in vivo stability. The radiolabeling efficiency of Y-90 exceeded 99% and the leaching rate of Y-90 is far below 0.1%. Furthermore, the excellent anti-tumor effect, nuclide loading stability, anti-reflux characteristics, precise embolization, and biosafety of ⁹⁰Y-HUACM were validated in a rabbit VX₂ liver tumor model. In summary, this new, high-performance, and customizable radioactive microsphere provides a superior choice for selective internal radiation treatment of advanced liver cancer is expected to be rapidly applied in clinical practice.
- Carbon microsphere,
- Yttrium-90,
- Selective internal radiation therapy,
- Liver cancer,
- Radioactive
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1.
沈阳化工大学材料科学与工程学院沈阳 110142