Citation: Tianxu Zhang, Dexuan Xiao, Mi Zhou, Yunfeng Lin, Tao Zhang, Xiaoxiao Cai. Protective effect of osteogenic growth peptide functionalized tetrahedral DNA nanostructure on bone marrow and bone formation ability in chemotherapy-induced myelosuppressive mice[J]. Chinese Chemical Letters, ;2025, 36(8): 110594. doi: 10.1016/j.cclet.2024.110594 shu

Protective effect of osteogenic growth peptide functionalized tetrahedral DNA nanostructure on bone marrow and bone formation ability in chemotherapy-induced myelosuppressive mice

Tianxu Zhang ^{a, b} ,
Dexuan Xiao ^a ,
Mi Zhou ^a ,
Yunfeng Lin ^{a, c, d} ,
Tao Zhang ^{a, b, *,} ,
Xiaoxiao Cai ^{a, c, *,}

a.
State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
b.
Department of general dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
c.
Sichuan Provincial Engineering Research Center of Oral Biomaterials, Chengdu 610041, China
d.
National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China

taozhang@scu.edu.cn

xcai@scu.edu.cn

Received Date: 23 August 2024
Revised Date: 19 October 2024
Accepted Date: 29 October 2024
Available Online: 30 October 2024

Figures(4)

Osteogenic ability impairment and myelosuppression are common complications of chemotherapy and many chemotherapeutics can affect the skeletal system. Skeletal system protection is necessary for cancer chemotherapy. In this study, osteogenic growth peptide (OGP) and tetrahedral framework nucleic-acid nanostructures (tFNAs) are combined to form a peptide-DNA complex OGP-tFNAs, which aims to combine the positive biological effect on tissue protection and regeneration. The bone marrow protection and bone formation effect of OGP-tFNAs are investigated in chemotherapy-induced myelosuppressive mice. The results show that OGP-tFNAs could reduce the cell damage degree from 5-fluorouracil (5-FU) in vitro and maintained the osteogenic differentiation potential. Furthermore, OGP-tFNAs accelerate bone defect regeneration in myelosuppressive mice. In conclusion, OGP-tFNAs could protect the osteogenic differentiation potential of bone marrow stromal cells (BMSCs) from 5-FU injury and maintain the bone formation ability of myelosuppressive mice suffering from chemotherapy.
- Peptide-DNA nanocomplex,
- Chemotherapy,
- Bone formation,
- Tetrahedral framework nucleic-acid nanostructure,
- Osteogenic growth peptide
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