Citation: Xiangrong Pan, Xixi Hou, Yuhang Du, Zhixin Pang, Shiyang He, Lan Wang, Jianxue Yang, Longfei Mao, Jianhua Qin, Haixia Wu, Baozhong Liu, Zhan Zhou, Lufang Ma, Chaoliang Tan. Solvent-mediated synthesis of 2D In-TCPP MOF nanosheets for enhanced photodynamic antibacterial therapy[J]. Chinese Chemical Letters, ;2025, 36(12): 110536. doi: 10.1016/j.cclet.2024.110536 shu

Solvent-mediated synthesis of 2D In-TCPP MOF nanosheets for enhanced photodynamic antibacterial therapy

Xiangrong Pan ^{a, c} ,
Xixi Hou ^b ,
Yuhang Du ^a ,
Zhixin Pang ^a ,
Shiyang He ^a ,
Lan Wang ^d ,
Jianxue Yang ^b ,
Longfei Mao ^{d, *,} ,
Jianhua Qin ^a ,
Haixia Wu ^a ,
Baozhong Liu ^c ,
Zhan Zhou ^{a, *,} ,
Lufang Ma ^{a, c, *,} ,
Chaoliang Tan ^{e, f, *,}

a.
College of Chemistry and Chemical Engineering, Henan Key Laboratory of Function-Oriented Porous Materials, Luoyang Normal University, Luoyang 471934, China
b.
The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, China
c.
College of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo 454000, China
d.
College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang 471003, China
e.
Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR 999077, China
f.
Department of Electrical Engineering, City University of Hong Kong, Hong Kong SAR 999077, China

longfeimao1988@163.com

zhouzhan@lynu.edu.cn

mazhuxp@126.com

chaoltan@cityu.edu.hk

Received Date: 22 August 2024
Revised Date: 28 September 2024
Accepted Date: 8 October 2024
Available Online: 11 October 2024

Figures(5)

Two-dimensional (2D) metal-organic frameworks (MOFs) have emerged as promising photosensitizers in photodynamic therapy in recent years. In comparison to bulk MOFs, constructing 2D MOFs can increase the presence of active sites through increasing the surface area ratio. Herein, we report a simple solvent-mediated synthesis method for preparation of 2D porphyrin-based MOF (In-TCPP) nanosheets without the addition of any surfactants as an efficient photosensitizer for enhancing photodynamic antibacterial therapy. The accurate regulation of the morphology and size of 2D In-TCPP nanosheets can be achieved by varying the ratio of water to N,N-dimethylformamide solvent with the appropriate assistance of pyridine. The optimal synthesized 2D In-TCPP nanosheets exhibit a diameter of 70–120 nm and a thickness of 21.5–27.4 nm. Promisingly, 2D In-TCPP nanosheets produce a higher amount of ¹O₂ when exposed to 660 nm laser compared to the In-TCPP bulk, indicating that the smaller nanosheets possess more active sites for reactive oxygen species generation and can greatly improve the antibacterial photodynamic therapeutic effect. Both the in vitro and in vivo results prove that the In-TCPP nanosheets can be used as a photosensitizer for efficient photodynamic antibacterial therapy to kill S. aureus and promote wound healing.
- Two-dimensional nanosheets,
- Metal-organic frameworks,
- Photosensitizers,
- Photodynamic therapy,
- Antibacterial
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