Citation: Junfei Yang, Ke Wang, Shuxin Sun, Tianqi Pei, Junxiu Li, Xunwei Gong, Cuixia Zheng, Yun Zhang, Qingling Song, Lei Wang. A "spore-like" oral nanodrug delivery platform for precision targeted therapy of inflammatory bowel disease[J]. Chinese Chemical Letters, ;2025, 36(3): 110180. doi: 10.1016/j.cclet.2024.110180 shu

A "spore-like" oral nanodrug delivery platform for precision targeted therapy of inflammatory bowel disease

Junfei Yang ^{a, b} ,
Ke Wang ^{a, b} ,
Shuxin Sun ^{a, b} ,
Tianqi Pei ^{a, b} ,
Junxiu Li ^{a, b} ,
Xunwei Gong ^{a, b} ,
Cuixia Zheng ^c ,
Yun Zhang ^{a, b} ,
Qingling Song ^{a, b, *,} ,
Lei Wang ^{a, b, *,}

a.
School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China
b.
Henan Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Zhengzhou 450001, China
c.
Henan University, Huaihe Hospital, Translational Medicine Center, Kaifeng 475000, China

songqingling@zzu.edu.cn

wanglei1@zzu.edu.cn

Received Date: 9 April 2024
Revised Date: 23 June 2024
Accepted Date: 26 June 2024
Available Online: 26 June 2024

Figures(5)

Colon-targeted oral drug delivery systems are one of the most promising therapeutic strategies for alleviating and curing inflammatory bowel disease (IBD), but they still face challenges in successfully passing through the harsh gastrointestinal environment and intestinal mucus barrier. To overcome the gastrointestinal barriers for oral drug delivery mentioned above, a "spore-like" oral nanodrug delivery platform (Cur/COS/SC NPs) has been developed. Firstly, chitooligosaccharides (COS) are encapsulated on the surface of Curcumin nanoparticles (Cur NPs) to form carrier-free nanoparticles (Cur/COS NPs). Subsequently, inspired by the natural high resistance of spore coat (SC), SC is chosen as the "protective umbrella" to encapsulate Cur/COS NPs for precision targeted therapy of IBD. After oral administration, SC can effectively protect NPs through the rugged gastrointestinal environment and exhibit excellent intestinal mucus penetration characteristics. Moreover, the negatively-charged Cur/COS/SC NPs specifically target positively-charged inflamed colon via electrostatic interactions. It is demonstrated that Cur/COS/SC NPs can promote the expression of tight junction proteins, inhibit aberrant activation of the Toll-like receptor 4/myeloid differentiation primary response gene 88/nuclear factor-κB (TLR4/MyD88/NF-κB) signaling pathway, and downregulate the levels of pro-inflammatory factors, exhibiting excellent anti-inflammatory effects. Notably, it is found that Cur/COS/SC NPs can significantly increase the richness and diversity of gut microbiota, and restore the homeostasis of gut microbiota by inhibiting pathogenic bacteria and promoting probiotics. Hence, Cur/COS/SC NPs provide a safe, efficient, and feasible new strategy for IBD treatment.
- Gastrointestinal barrier,
- Spore-like,
- Precision targeted therapy,
- Spore coat,
- Gut microbiota
1. [1]
  A.T. Rahman, J. Shin, C.-H. Whang, et al., ACS Nano 17 (2023) 10996–11013. doi: 10.1021/acsnano.3c03252
2. [2]
  N.G. Kotla, Y. Rochev, Trends Mol. Med. 29 (2023) 241–253.
3. [3]
  C. Yu, D. Wang, Z. Yang, T. Wang, Int. J. Mol. Sci. 23 (2022) 6939. doi: 10.3390/ijms23136939
4. [4]
  K. Rajamaki, A. Taira, R. Katainen, et al., Gastroenterol. 161 (2021) 592–607.
5. [5]
  L. Liang, R. Lin, Y. Xie, et al., Int. J. Biol. Sci. 17 (2021) 2548–2560. doi: 10.7150/ijbs.58671
6. [6]
  J.F. Colombel, P. Rutgeerts, W. Reinisch, et al., Gastroenterol. 141 (2011) 1194–1201.
7. [7]
  H.S. Sardo, F. Saremnejad, S. Bagheri, et al., Int. J. Pharm. 558 (2019) 367–379.
8. [8]
  H. Liu, Z. Cai, F. Wang, et al., Adv. Sci. 8 (2021) 2101619.
9. [9]
  D. Dehaini, R.H. Fang, L. Zhang, Bioeng. Transl. Med. 1 (2016) 30–46. doi: 10.1002/btm2.10004
10. [10]
  J. Wang, H. Pan, J. Li, et al., Chin. Chem. Lett. 34 (2023) 107828.
11. [11]
  E. Wang, R. Han, M. Wu, et al., Chin. Chem. Lett. 35 (2024) 108361.
12. [12]
  Y. Xu, N. Shrestha, V. Preat, A. Beloqui, J. Control. Release 322 (2020) 486–508.
13. [13]
  A.M. dos Santos, S.G. Carvalho, A.B. Meneguin, et al., J. Control. Release 334 (2021) 353–366.
14. [14]
  S. Davoodi, E. Foley, Front. Immunol. 10 (2020) 3128.
15. [15]
  X. Zhu, K. Zhang, X. Teng, et al., Chem 9 (2023) 1094–1117.
16. [16]
  H. Gou, H. Su, D. Liu, et al., Gastroenterology 165 (2023) 1404–1419.
17. [17]
  R. Wu, R. Xiong, Y. Li, J. Chen, R. Yan, J. Autoimmun. 141 (2023) 103062.
18. [18]
  J. Ni, G.D. Wu, L. Albenberg, V.T. Tomov, Nat. Rev. Gastroenterol. Hepatol. 14 (2017) 573–584. doi: 10.1038/nrgastro.2017.88
19. [19]
  M. Pesce, L. Seguella, A. Del Re, et al., Int. J. Mol. Sci. 23 (2022) 5466. doi: 10.3390/ijms23105466
20. [20]
  H. Luo, G. Cao, C. Luo, et al., Pharmacol. Res. 178 (2022) 106146.
21. [21]
  Q. Song, H. Zhao, C. Zheng, et al., Adv. Funct. Mater. 31 (2021) 2104994.
22. [22]
  Q. Song, C. Zheng, J. Jia, et al., Adv. Mater. 31 (2019) 1903793.
23. [23]
  G. Christie, P. Setlow, Cell. Signalling. 74 (2020) 1093793.
24. [24]
  J. Yin, L. Wei, N. Wang, X. Li, M. Miao, J. Ethnopharmacol. 289 (2022) 115041.
25. [25]
  S.S. Kesharwani, R. Ahmad, M.A. Bakkari, et al., J. Controlled Release. 290 (2018) 165–179.
26. [26]
  J.D. Lewis, M.T. Abreu, Gastroenterol. 152 (2017) 398–414.
27. [27]
  J. Zhang, S. Li, F. -F. An, et al., Nanoscale. 7 (2015) 13503–13510.
28. [28]
  Y. Wang, Y. Li, L. He, et al., Colloids Surf. B: Biointerfaces 203 (2021) 111756.
29. [29]
  W. Xia, P. Liu, J. Zhang, J. Chen, Food Hydrocoll. 25 (2011) 170–179.
30. [30]
  B. Zhu, H. He, D. Guo, M. Zhao, T. Hou, Food Hydrocoll. 102 (2020) 105567.
31. [31]
  X. Wei, L. Yu, C. Zhang, et al., Carbohydr. Polym. 299 (2023) 120156.
32. [32]
  Y. Wang, J. Lin, Z. Cheng, et al., Oxid. Med. Cell. Longevity. 2022 (2022) 5462390.
33. [33]
  S. Zhao, Y. Li, Q. Liu, et al., Adv. Funct. Mater. 30 (2020) 2004692.
34. [34]
  K. Wei, F. Gong, J. Wu, et al., ACS Nano 17 (2023) 21539–21552. doi: 10.1021/acsnano.3c06551
35. [35]
  X.Q. Sang, W.J. Yan, X.F. Qin, et al., Chin. J. Anal. Chem. 51 (2023) 100194.
36. [36]
  E. Ricca, S.M. Cutting, J. Nanobiotechnol. 1 (2003) 6.
37. [37]
  C.T. Nordgard, K.I. Draget, Adv. Drug Deliv. Rev. 124 (2018) 175–183.
38. [38]
  C. Menzel, A. Bernkop-Schnuerch, Adv. Drug Deliv. Rev. 124 (2018) 164–174.
39. [39]
  N.P. Gabrielson, H. Lu, L. Yin, et al., Angew. Chem. Int. Ed. 51 (2012) 1143–1147. doi: 10.1002/anie.201104262
40. [40]
  H.X. Wang, Z. Song, Y.H. Lao, et al., Proc. Nat. Acad. Sci. 115 (2018) 4903–4908. doi: 10.1073/pnas.1712963115
41. [41]
  F.J. Enguita, L.O. Martins, A.O. Henriques, M.A. Carrondo, J. Biol. Chem. 278 (2003) 19416–19425.
42. [42]
  P. Moller, D.M. Jensen, D.V. Christophersen, et al., Environ. Mol. Mutagen. 56 (2015) 97–110. doi: 10.1002/em.21899
43. [43]
  W.T. Kuo, M.A. Odenwald, J.R. Turner, L. Zuo, Ann. NY Acad. Sci. 1514 (2022) 21–33. doi: 10.1111/nyas.14798
44. [44]
  X. Mao, R. Sun, Q. Wang, et al., Front. Immunol. 12 (2022) 817583.
45. [45]
  N. Ma, D. Ma, X. Liu, et al., Environ. Int. 175 (2023) 107949.
46. [46]
  Y.C. Lu, W.C. Yeh, P.S. Ohashi, Cytokine. 42 (2008) 145–151.
47. [47]
  A. Lavelle, H. Sokol, Nat. Rev. Gastro. Hepat. 17 (2020) 223–237. doi: 10.1038/s41575-019-0258-z
48. [48]
  B. Chassaing, A.T. Gewirtz, Toxicol. Pathol. 42 (2014) 49–53. doi: 10.1177/0192623313508481
49. [49]
  H. Sokol, S. Jegou, C. McQuitty, et al., Gut Microbes 9 (2018) 55–60.
50. [50]
  L. Mei, J. Guo, R. He, et al., Small 19 (2023) 202301129.
51. [51]
  B. Zhang, X. Fan, H. Du, et al., ACS Nano 17 (2023) 6081–6094. doi: 10.1021/acsnano.3c01005
52. [52]
  C. Binda, L.R. Lopetuso, G. Rizzatti, et al., Digest. Liver Dis. 50 (2018) 421–428.
53. [53]
  T. Magrone, E. Jirillo, Immun. Ageing 10 (2013) 31.
54. [54]
  X. Zhong, Y. Zhao, L. Huang, et al., Front. Microbiol. 14 (2023) 1140498.
55. [55]
  Y. Wang, X. Nan, Y. Zhao, et al., Microbiol. Spectrum. 9 (2021) e00105–21.
1. [1]
  Han Wu , Yumei Wang , Zekai Ren , Hailin Cong , Youqing Shen , Bing Yu . The nanocarrier strategy for crossing the blood-brain barrier in glioma therapy. Chinese Chemical Letters, 2025, 36(4): 109996-. doi: 10.1016/j.cclet.2024.109996
2. [2]
  Chao Zhang , Ai-Feng Liu , Shihui Li , Fang-Yuan Chen , Jun-Tao Zhang , Fang-Xing Zeng , Hui-Chuan Feng , Ping Wang , Wen-Chao Geng , Chuan-Rui Ma , Dong-Sheng Guo . A supramolecular formulation of icariin@sulfonatoazocalixarene for hypoxia-targeted osteoarthritis therapy. Chinese Chemical Letters, 2025, 36(1): 109752-. doi: 10.1016/j.cclet.2024.109752
3. [3]
  Hao Cai , Xiaoyan Wu , Lei Jiang , Feng Yu , Yuxiang Yang , Yan Li , Xian Zhang , Jian Liu , Zijian Li , Hong Bi . Lysosome-targeted carbon dots with a light-controlled nitric oxide releasing property for enhanced photodynamic therapy. Chinese Chemical Letters, 2024, 35(4): 108946-. doi: 10.1016/j.cclet.2023.108946
4. [4]
  Shuheng Zhang , Yuanyuan Zhang , Wanyu Wang , Yuzhu Hu , Xinchuan Chen , Bilan Wang , Xiang Gao . A combination strategy of DOX and VEGFR-2 targeted inhibitor based on nanomicelle for enhancing lymphoma therapy. Chinese Chemical Letters, 2024, 35(12): 109658-. doi: 10.1016/j.cclet.2024.109658
5. [5]
  Yu-Hui Zhang , Ye Tian , Xianliang Sheng , Chen-Shuang Liu , Lu-Qiang Wei , Jie Wang , Yong Chen . Construction of a black phosphorous-based noncovalent multiple nanosupramolecular assembly for synergistic targeted photothermal and chemodynamic therapy. Chinese Chemical Letters, 2025, 36(4): 110193-. doi: 10.1016/j.cclet.2024.110193
6. [6]
  Yihan Zhou , Duo Gao , Yaying Wang , Li Liang , Qingyu Zhang , Wenwen Han , Jie Wang , Chunliu Zhu , Xinxin Zhang , Yong Gan . Worm-like micelles facilitate the intestinal mucus diffusion and drug accumulation for enhancing colorectal cancer therapy. Chinese Chemical Letters, 2024, 35(6): 108967-. doi: 10.1016/j.cclet.2023.108967
7. [7]
  Shangqian Zhang , Jiaxuan Li , Xuan Hu , Zelong Chen , Junliang Dong , Chenhao Hu , Shuang Chao , Yinghua Lv , Yuxin Pei , Zhichao Pei . H₂S and NIR light-driven nanomotors induce disulfidptosis for targeted anticancer therapy by enhancing disruption of tumor metabolic symbiosis. Chinese Chemical Letters, 2025, 36(1): 110314-. doi: 10.1016/j.cclet.2024.110314
8. [8]
  Qinyu Zhao , Yunchao Zhao , Songjing Zhong , Zhaoyang Yue , Zhuoheng Jiang , Shaobo Wang , Quanhong Hu , Shuncheng Yao , Kaikai Wen , Linlin Li . Urchin-like piezoelectric ZnSnO₃/Cu₃P p-n heterojunction for enhanced cancer sonodynamic therapy. Chinese Chemical Letters, 2024, 35(12): 109644-. doi: 10.1016/j.cclet.2024.109644
9. [9]
  Ling Tang , Yan Wan , Yangming Lin . Lowering the kinetic barrier via enhancing electrophilicity of surface oxygen to boost acidic oxygen evolution reaction. Chinese Journal of Structural Chemistry, 2024, 43(11): 100345-100345. doi: 10.1016/j.cjsc.2024.100345
10. [10]
  Yu Yan , Jiawei Song , Dongdong Liu , Zihan Liu , Jialing Cheng , Zhiyang Chen , Yanfang Yang , Weizhe Jiang , Hongliang Wang , Jun Ye , Yuling Liu . Simple and versatile in situ thermo-sensitive hydrogel for rectal administration of SZ-A to alleviate inflammation and repair mucosal barrier in ulcerative colitis. Chinese Chemical Letters, 2024, 35(6): 109736-. doi: 10.1016/j.cclet.2024.109736
11. [11]
  Lei Shen , Hongmei Liu , Ming Jin , Jinchao Zhang , Caixia Yin , Shuxiang Wang , Yutao Yang . “Three-in-one” strategy of trifluoromethyl regulated blood-brain barrier permeable fluorescent probe for peroxynitrite and antiepileptic evaluation of edaravone. Chinese Chemical Letters, 2024, 35(10): 109572-. doi: 10.1016/j.cclet.2024.109572
12. [12]
  Jiayao Li , Xinru Peng , Shiwei Yin , Changwei Wang , Yirong Mo . Metastability of π-π stacking between the closed-shell ions of like charges. Chinese Journal of Structural Chemistry, 2024, 43(5): 100213-100213. doi: 10.1016/j.cjsc.2023.100213
13. [13]
  Wenying Cui , Zhetong Jin , Wentao Fu , Chengshuo Shen . Flag-hinge-like highly luminescent chiral nanographenes with twist geometry. Chinese Chemical Letters, 2024, 35(11): 109667-. doi: 10.1016/j.cclet.2024.109667
14. [14]
  Han Han , Bi-Te Chen , Jia-Rong Ding , Jin-Ming Si , Tian-Jiao Zhou , Yi Wang , Lei Xing , Hu-Lin Jiang . A PDGFRβ-targeting nanodrill system for pancreatic fibrosis therapy. Chinese Chemical Letters, 2024, 35(10): 109583-. doi: 10.1016/j.cclet.2024.109583
15. [15]
  Jialiang XU , Jiabin CUI . Recent biological applications of corroles: From diagnosis to therapy. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2303-2317. doi: 10.11862/CJIC.20240245
16. [16]
  Jing Guo , Zhi-Guo Lu , Rui-Chen Zhao , Bao-Ku Li , Xin Zhang . Nucleic acid therapy for metabolic-related diseases. Chinese Chemical Letters, 2025, 36(3): 109875-. doi: 10.1016/j.cclet.2024.109875
17. [17]
  Botao QU , Qian WANG , Xiaogang NING , Yuxin ZHOU , Ruiping ZHANG . Deeply penetrating photoacoustic imaging in tumor tissues based on dual-targeted melanin nanoparticle. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 1025-1032. doi: 10.11862/CJIC.20230416
18. [18]
  Kun-Heng Li , Hong-Yang Zhao , Dan-Dan Wang , Ming-Hui Qi , Zi-Jian Xu , Jia-Mi Li , Zhi-Li Zhang , Shi-Wen Huang . Mitochondria-targeted nano-AIEgens as a powerful inducer for evoking immunogenic cell death. Chinese Chemical Letters, 2024, 35(5): 108882-. doi: 10.1016/j.cclet.2023.108882
19. [19]
  Bin Fang , Jiaqi Yang , Limin Wang , Haoqin Li , Jiaying Guo , Jiaxin Zhang , Qingyuan Guo , Bo Peng , Kedi Liu , Miaomiao Xi , Hua Bai , Li Fu , Lin Li . A mitochondria-targeted H₂S-activatable fluorogenic probe for tracking hepatic ischemia-reperfusion injury. Chinese Chemical Letters, 2024, 35(6): 108913-. doi: 10.1016/j.cclet.2023.108913
20. [20]
  Yiqiao Chen , Ao Liu , Biwen Yang , Zhenzhen Li , Binggang Ye , Zhouyi Guo , Zhiming Liu , Haolin Chen . Photoluminescence and photothermal conversion in boric acid derived carbon dots for targeted microbial theranostics. Chinese Chemical Letters, 2024, 35(9): 109295-. doi: 10.1016/j.cclet.2023.109295

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(135)
HTML views(6)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142