Citation: Zhi Li, Shuya Pan, Yuan Tian, Shaowei Liu, Weifeng Wei, Jinlin Wang, Tianfeng Chen, Ling Wang. Selenium nanoparticles enhance the chemotherapeutic efficacy of pemetrexed against non-small cell lung cancer[J]. Chinese Chemical Letters, ;2024, 35(12): 110018. doi: 10.1016/j.cclet.2024.110018 shu

Selenium nanoparticles enhance the chemotherapeutic efficacy of pemetrexed against non-small cell lung cancer

Zhi Li ^a ,
Shuya Pan ^b ,
Yuan Tian ^c ,
Shaowei Liu ^d ,
Weifeng Wei ^d ,
Jinlin Wang ^d ,
Tianfeng Chen ^{a, c, *,} ,
Ling Wang ^{a, *,}

a.
Faculty of Medicine, Macau University of Science and Technology, Macao 999078, China
b.
Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China
c.
College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, China
d.
Pulmonary and Critical Care Medicine, Guangzhou Institute of Respiratory Health, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, State Key Laboratory of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China

tchentf@jnu.edu.cn

lingwang@must.edu.mo

Received Date: 11 April 2024
Revised Date: 12 May 2024
Accepted Date: 15 May 2024
Available Online: 16 May 2024

Figures(5)

Selenium (Se) plays an important role in the development and treatment of lung cancer, yet its specific mechanisms remain elusive. Lower Se level in serum was noted in lung cancer patients compared to normal controls. Therefore, developing effective therapeutic adjuvants containing Se might benefit the treatment of lung cancer patients. This study aimed to investigate the association between Se and the chemotherapeutic efficacy of lung cancer. Lentinan-modified selenium nanoparticles (LET-SeNPs) were created to develop and verify the effectiveness of Se containing adjuvant applied with pemetrexed on lung cancer cells. A synergistic effect was observed between LET-SeNPs and pemetrexed in vitro. The combination of LET-SeNPs and pemetrexed could induce reactive oxygen species overproduction, mitochondrial dysfunction and DNA damage, ultimately leading to cancer cell apoptosis. It is implied that LET-SeNPs might be a promising sensitizer to pemetrexed chemotherapy and could potentially enhance chemotherapy efficiency in non-small cell lung cancer.
- Selenium nanoparticles,
- Lentinan,
- Chemotherapy,
- Pemetrexed,
- Non-small cell lung cancer,
- Apoptosis
1. [1]
  A. Leiter, R.R. Veluswamy, J.P. Wisnivesky, Nat. Rev. Clin. Oncol. 20 (2023) 624–639. doi: 10.1038/s41571-023-00798-3
2. [2]
  H. Hall, A. Tocock, S. Burdett, et al., Thorax 77 (2022) 762–768. doi: 10.1136/thoraxjnl-2021-216865
3. [3]
  M. Guirado, E. Fernández Martín, A. Fernández Villar, A. Navarro Martín, A. Sánchez-Hernández, Clin. Transl. Oncol. 24 (2022) 1549–1568. doi: 10.1007/s12094-022-02796-w
4. [4]
  F. Bray, M. Laversanne, H. Sung, et al., CA Cancer J. Clin. 74 (2024) 229–263. doi: 10.3322/caac.21834
5. [5]
  Y. Zhang, S. Vaccarella, E. Morgan, et al., Lancet Oncol. 24 (2023) 1206–1218. doi: 10.1016/S1470-2045(23)00444-8
6. [6]
  Y. Li, B. Yan, S. He, Biomed. Pharmacother. 169 (2023) 115891. doi: 10.1016/j.biopha.2023.115891
7. [7]
  G.V. Scagliotti, P. Parikh, J. Pawel, et al., J. Clin. Oncol. 41 (2023) 2458–2466. doi: 10.1200/jco.22.02544
8. [8]
  T. Gonzalez, M. Muminovic, O. Nano, M. Vulfovich, Int. J. Mol. Sci. 25 (2024) 1046. doi: 10.3390/ijms25021046
9. [9]
  N. Rouw, R.J. Boosman, H. Bruinhorst, et al., Lung Cancer 146 (2020) 30–35. doi: 10.1016/j.lungcan.2020.05.022
10. [10]
  F. Li, H. Wang, Y. Xiang, et al., Transl. Lung Cancer Res. 12 (2023) 2381–2391. doi: 10.21037/tlcr-23-489
11. [11]
  S. Visser, S.L.W. Koolen, P. Bruijn, et al., Eur. J. Cancer 121 (2019) 64–73. doi: 10.1016/j.ejca.2019.08.012
12. [12]
  N. Rouw, M. Boer, R.J. Boosman, et al., Clin. Pharmacol. Ther. 111 (2022) 1103–1110. doi: 10.1002/cpt.2529
13. [13]
  C. Gridelli, F. Marinis, M. Thomas, et al., J. Thorac. Oncol. 9 (2014) 991–997. doi: 10.1097/JTO.0000000000000207
14. [14]
  M. Roman, P. Jitaru, C. Barbante, Metallomics 6 (2014) 25–54. doi: 10.1039/C3MT00185G
15. [15]
  A. Mojadadi, A. Au, W. Salah, P. Witting, G. Ahmad, Nutrients 13 (2021) 3256–3277. doi: 10.3390/nu13093256
16. [16]
  S.J. Fairweather-Tait, Y. Bao, M.R. Broadley, et al., Antioxid. Redox. Signal. 14 (2011) 1337–1383. doi: 10.1089/ars.2010.3275
17. [17]
  M.P. Rayman, Lancet 379 (2012) 1256–1268. doi: 10.1016/S0140-6736(11)61452-9
18. [18]
  X.L. Liao, Z.H. Wang, X.N. Liang, et al., Diabet. Metab. Syndr. Obes. 13 (2020) 4755–4761. doi: 10.2147/dmso.s284120
19. [19]
  A.A. Al-Mubarak, N. Grote Beverborg, N. Suthahar, et al., Eur. J. Heart Fail. 24 (2022) 299–307. doi: 10.1002/ejhf.2405
20. [20]
  J.C. Avery, P.R. Hoffmann, Nutrients 10 (2018) 1203–1223. doi: 10.3390/nu10091203
21. [21]
  H. Chen, H. Zhang, L. Cao, et al., Cancer 14 (2022) 345–362. doi: 10.3390/cancers14020345
22. [22]
  S. Liu, N. Li, H. Lai, et al., Adv. Funct. Mater. 34 (2024) 2401264. doi: 10.1002/adfm.202401264
23. [23]
  B. Deng, X. He, D. Wang, et al., Small Method. 7 (2023) e2300293. doi: 10.1002/smtd.202300293
24. [24]
  B. Xie, D. Zeng, M. Yang, et al., ACS Nano 17 (2023) 14053–14068. doi: 10.1021/acsnano.3c04344
25. [25]
  B. Feng, Y. Zhang, T. Liu, et al., Chin. Chem. Lett. 34 (2023) 108264. doi: 10.1016/j.cclet.2023.108264
26. [26]
  J. Ouyang, B. Deng, B. Zou, et al., J. Am. Chem. Soc. 145 (2023) 12193–12205. doi: 10.1021/jacs.3c02179
27. [27]
  Y. Xu, H. Lai, S. Pan, et al., Biomaterials 305 (2024) 122452. doi: 10.1016/j.biomaterials.2023.122452
28. [28]
  Y. Feng, J. Wang, J. Cao, F. Cao, X. Chen, Exploration 4 (2024) 20230019. doi: 10.1002/EXP.20230019
29. [29]
  J. Wang, Q. Zhang, Y. Li, et al., Chin. Chem. Lett. 35 (2024) 108746. doi: 10.1016/j.cclet.2023.108746
30. [30]
  P. Zheng, J. Ding, Asian J. Pharm. Sci. 17 (2022) 1–3. doi: 10.1016/j.ajps.2021.10.004
31. [31]
  Y. Wu, W. Chen, C. Wang, D. Xing, Chin. Chem. Lett. 35 (2024) 109096. doi: 10.1016/j.cclet.2023.109096
32. [32]
  Z. Zhang, Y. Du, T. Liu, K.H. Wong, T. Chen, Biomater. Sci. 7 (2019) 5112–5123. doi: 10.1039/c9bm01104h
33. [33]
  J. Huang, W. Huang, Z. Zhang, et al., ACS Appl. Mater. Interface. 11 (2019) 11177–11193. doi: 10.1021/acsami.8b22678
34. [34]
  Y. Chang, J. Huang, S. Shi, et al., Adv. Mater. 35 (2023) 2212178. doi: 10.1002/adma.202212178
35. [35]
  J. Ling, Y. Chang, Z. Yuan, et al., ACS Appl. Mater. Interface. 14 (2022) 27651–27665. doi: 10.1021/acsami.2c05533
36. [36]
  Y. Yang, Z. Zhang, Q. Chen, et al., Front. Bioeng. Biotechnol. 9 (2021) 758482. doi: 10.3389/fbioe.2021.758482
37. [37]
  Z. Song, W. Luo, H. Zheng, et al., Adv. Healthc. Mater. 10 (2021) e2100149. doi: 10.1002/adhm.202100149
38. [38]
  Y. Yang, Y. Wang, L. Xu, T. Chen, Chin. Chem. Lett. 31 (2020) 1801–1806. doi: 10.1016/j.cclet.2020.03.004
39. [39]
  E. Vringer, S.W.G. Tait, Cell Death Differ. 30 (2023) 304–312. doi: 10.1038/s41418-022-01094-w
40. [40]
  F. Cai, K. Ye, M. Chen, et al., Chin. Chem. Lett. 34 (2023) 107945–107949. doi: 10.1016/j.cclet.2022.107945
1. [1]
  Zhiyu Yu , Xiang Luo , Cheng Zhang , Xin Lu , Xiaohui Li , Pan Liao , Zhongqiu Liu , Rong Zhang , Shengtao Wang , Zhiqiang Yu , Guochao Liao . Mitochondria-targeted carrier-free nanoparticles based on dihydroartemisinin against hepatocellular carcinoma. Chinese Chemical Letters, 2024, 35(10): 109519-. doi: 10.1016/j.cclet.2024.109519
2. [2]
  Tingting Hu , Chao Shen , Xueyan Wang , Fengbo Wu , Zhiyao He . Tumor microenvironment-sensitive polymeric nanoparticles for synergetic chemo-photo therapy. Chinese Chemical Letters, 2024, 35(11): 109562-. doi: 10.1016/j.cclet.2024.109562
3. [3]
  Wenbin Zhou , Yafei Gao , Xinyu Feng , Yanqing Zhang , Cong Yang , Lanxi He , Fenghe Zhang , Xiaoguang Li , Qing Li . Biomimetic nanoplatform integrates FRET-enhanced photodynamic therapy and chemotherapy for cascaded revitalization of the tumor immune microenvironment in OSCC. Chinese Chemical Letters, 2025, 36(1): 109763-. doi: 10.1016/j.cclet.2024.109763
4. [4]
  Cheng-Zhe Gao , Hao-Ran Jia , Tian-Yu Wang , Xiao-Yu Zhu , Xiaofeng Han , Fu-Gen Wu . A dual drug-loaded tumor vasculature-targeting liposome for tumor vasculature disruption and hypoxia-enhanced chemotherapy. Chinese Chemical Letters, 2025, 36(1): 109840-. doi: 10.1016/j.cclet.2024.109840
5. [5]
  Wenyi Mei , Lijuan Xie , Xiaodong Zhang , Cunjian Shi , Fengzhi Wang , Qiqi Fu , Zhenjiang Zhao , Honglin Li , Yufang Xu , Zhuo Chen . Design, synthesis and biological evaluation of fluorescent derivatives of ursolic acid in living cells. Chinese Chemical Letters, 2024, 35(5): 108825-. doi: 10.1016/j.cclet.2023.108825
6. [6]
  Chuyu Huang , Zhishan Liu , Linping Zhao , Zuxiao Chen , Rongrong Zheng , Xiaona Rao , Yuxuan Wei , Xin Chen , Shiying Li . Metal-coordinated oxidative stress amplifier to suppress tumor growth combined with M2 macrophage elimination. Chinese Chemical Letters, 2024, 35(12): 109696-. doi: 10.1016/j.cclet.2024.109696
7. [7]
  Du Liu , Yuyan Li , Hankun Zhang , Benhua Wang , Chaoyi Yao , Minhuan Lan , Zhanhong Yang , Xiangzhi Song . Three-in-one erlotinib-modified NIR photosensitizer for fluorescence imaging and synergistic chemo-photodynamic therapy. Chinese Chemical Letters, 2025, 36(2): 109910-. doi: 10.1016/j.cclet.2024.109910
8. [8]
  Xiangqian Cao , Chenkai Yang , Xiaodong Zhu , Mengxin Zhao , Yilin Yan , Zhengnan Huang , Jinming Cai , Jingming Zhuang , Shengzhou Li , Wei Li , Bing Shen . Synergistic enhancement of chemotherapy for bladder cancer by photothermal dual-sensitive nanosystem with gold nanoparticles and PNIPAM. Chinese Chemical Letters, 2024, 35(8): 109199-. doi: 10.1016/j.cclet.2023.109199
9. [9]
  Lin Li , Bingjun Sun , Jin Sun , Lin Chen , Zhonggui He . Binary prodrug nanoassemblies combining chemotherapy and ferroptosis activation for efficient triple-negative breast cancer therapy. Chinese Chemical Letters, 2024, 35(10): 109538-. doi: 10.1016/j.cclet.2024.109538
10. [10]
  Zhendong Liu , Sainan Liu , Bin Liu , Qi Meng , Meng Yuan , Chunzheng Yang , Yulong Bian , Ping'an Ma , Jun Lin . Fe(Ⅲ)-juglone nanoscale coordination polymers for cascade chemodynamic therapy through synergistic ferroptosis and apoptosis strategy. Chinese Chemical Letters, 2024, 35(11): 109626-. doi: 10.1016/j.cclet.2024.109626
11. [11]
  Jinyu Guo , Yandai Lin , Shaohua He , Yueqing Chen , Fenglu Li , Renjie Ruan , Gaoxing Pan , Hexin Nan , Jibin Song , Jin Zhang . Utilizing dual-responsive iridium(Ⅲ) complex for hepatocellular carcinoma: Integrating photoacoustic imaging with chemotherapy and photodynamic therapy. Chinese Chemical Letters, 2024, 35(9): 109537-. doi: 10.1016/j.cclet.2024.109537
12. [12]
  Weijian Zhang , Xianyu Deng , Liying Wang , Jian Wang , Xiuting Guo , Lianggui Huang , Xinyi Wang , Jun Wu , Linjia Jiang . Poly(ferulic acid) nanocarrier enhances chemotherapy sensitivity of acute myeloid leukemia by selectively targeting inflammatory macrophages. Chinese Chemical Letters, 2024, 35(9): 109422-. doi: 10.1016/j.cclet.2023.109422
13. [13]
  Chang LIU , Chao ZHANG , Tongbu LU . Small-size Au nanoparticles anchored on pyrenyl-graphdiyne for N₂ electroreduction. Chinese Journal of Inorganic Chemistry, 2025, 41(1): 174-182. doi: 10.11862/CJIC.20240305
14. [14]
  Yifei Zhang , Yuncong Xue , Laiwei Gao , Rui Liao , Feng Wang , Fei Wang . Merging non-covalent and covalent crosslinking: En route to single chain nanoparticles. Chinese Chemical Letters, 2024, 35(6): 109217-. doi: 10.1016/j.cclet.2023.109217
15. [15]
  Yiran Tao , Chunlei Dai , Zhaoxiang Xie , Xinru You , Kaiwen Li , Jun Wu , Hai Huang . Redox responsive polymeric nanoparticles enhance the efficacy of cyclin dependent kinase 7 inhibitor for enhanced treatment of prostate cancer. Chinese Chemical Letters, 2024, 35(8): 109170-. doi: 10.1016/j.cclet.2023.109170
16. [16]
  Shuang Liang , Jianjun Yao , Dan Liu , Mengli Zhou , Yong Cui , Zhaohui Wang . Tumor-responsive covalent organic polymeric nanoparticles enhancing STING activation for cancer immunotherapy. Chinese Chemical Letters, 2025, 36(3): 109856-. doi: 10.1016/j.cclet.2024.109856
17. [17]
  Jisheng Liu , Junli Chen , Xifeng Zhang , Yin Wu , Xin Qi , Jie Wang , Xiang Gao . Red blood cell membrane-coated FLT3 inhibitor nanoparticles to enhance FLT3-ITD acute myeloid leukemia treatment. Chinese Chemical Letters, 2024, 35(9): 109779-. doi: 10.1016/j.cclet.2024.109779
18. [18]
  Wenjia Wang , Xingyue He , Xiaojie Wang , Tiantian Zhao , Osamu Muraoka , Genzoh Tanabe , Weijia Xie , Tianjiao Zhou , Lei Xing , Qingri Jin , Hulin Jiang . Glutathione-depleted cyclodextrin pseudo-polyrotaxane nanoparticles for anti-inflammatory oxaliplatin (Ⅳ) prodrug delivery and enhanced colorectal cancer therapy. Chinese Chemical Letters, 2024, 35(4): 108656-. doi: 10.1016/j.cclet.2023.108656
19. [19]
  Jiahui Li , Qiao Shi , Ying Xue , Mingde Zheng , Long Liu , Tuoyu Geng , Daoqing Gong , Minmeng Zhao . The effects of in ovo feeding of selenized glucose on liver selenium concentration and antioxidant capacity in neonatal broilers. Chinese Chemical Letters, 2024, 35(6): 109239-. doi: 10.1016/j.cclet.2023.109239
20. [20]
  Lu Huang , Jiang Wang , Hong Jiang , Lanfang Chen , Huanwen Chen . On-line determination of selenium compounds in tea infusion by extractive electrospray ionization mass spectrometry combined with a heating reaction device. Chinese Chemical Letters, 2025, 36(1): 109896-. doi: 10.1016/j.cclet.2024.109896

Get Citation

PDF

XML

Metrics

PDF Downloads(1)
Abstract views(296)
HTML views(15)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142