Citation: Siqi Sun, Cheng Zhao, Zhaohuan Zhang, Ding Wang, Xinru Yin, Jingting Han, Jinlei Wei, Yong Zhao, Yongheng Zhu. Highly selective QCM sensor based on functionalized hierarchical hollow TiO₂ nanospheres for detecting ppb-level 3-hydroxy-2-butanone biomarker at room temperature[J]. Chinese Chemical Letters, ;2025, 36(5): 109939. doi: 10.1016/j.cclet.2024.109939 shu

Highly selective QCM sensor based on functionalized hierarchical hollow TiO₂ nanospheres for detecting ppb-level 3-hydroxy-2-butanone biomarker at room temperature

Siqi Sun ^{a, 1} ,
Cheng Zhao ^{a, b, 1} ,
Zhaohuan Zhang ^a ,
Ding Wang ^c ,
Xinru Yin ^a ,
Jingting Han ^a ,
Jinlei Wei ^a ,
Yong Zhao ^{a, *,} ,
Yongheng Zhu ^{a, *,}

a.
College of Food Science and Technology, Laboratory of Quality & Safety Risk Assessment for Aquatic Products on Storage and Preservation (Shanghai), Ministry of Agriculture and Shanghai Engineering Research Center of Aquatic Product Processing & Preservation, Shanghai Ocean University, Shanghai 201306, China
b.
Henan Railway Food Safety Management Engineering Technology Research Center, Zhengzhou Railway Vocational & Technical College, Zhengzhou 451460, China
c.
School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China

yzhao@shou.edu.cn

yh-zhu@shou.edu.cn

Received Date: 30 January 2024
Revised Date: 11 March 2024
Accepted Date: 28 April 2024
Available Online: 29 April 2024

Figures(5)

Listeria monocytogenes (LM) is a dangerous foodborne pathogen for humans. One emerging and validated method of indirectly assessing LM in food is detecting 3-hydroxy-2-butanone (3H2B) gas. In this study, the synthesis of 3-(2-aminoethylamino) propyltrimethoxysilane (AAPTMS) functionalized hierarchical hollow TiO₂ nanospheres was achieved via precise controlling of solvothermal reaction temperature and post-grafting route. The sensors based on as-prepared materials exhibited excellent sensitivity (480 Hz@50 ppm), low detection limit (100 ppb), and outstanding selectivity. Moreover, the evaluation of LM with high sensitivity and specificity was achieved using the sensors. Such stable three-dimensional spheres, whose distinctive hierarchical and hollow nanostructure simultaneously improved both sensitivity and response/recovery speed dramatically, were spontaneously assembled by nanosheets. Meanwhile, the moderate loadings of AAPTMS significantly improved the selectivity of sensors. Then, the gas-sensing mechanism was explored by utilizing thermodynamic investigation, Gaussian 16 software, and in situ diffuse reflectance infrared transform spectroscopy, illustrating the weak chemisorption between the -NH- group and 3H2B molecules. These portable sensors are promising for real-time assessment of LM at room temperature, which will make a magnificent contribution to food safety.
- Hierarchical hollow TiO₂ nanospheres,
- AAPTMS functionalization,
- Gas sensor,
- 3-Hydroxy-2-butanone detection,
- Sensing mechanism
1. [1]
  C. Fang, X.Y. Chen, X.Y. Liang, et al., Kafkas Univ. Vet. Fak. Derg. 25 (2019) 665–672.
2. [2]
  L.H. Kuang, Y.Y. Lai, Y.H. Gong, J. Obstet. Gynaecol. Res. 48 (2022) 66–72. doi: 10.1111/jog.15063
3. [3]
  S. Liu, X.L. He, T. Zhang, et al., Chin. Chem. Lett. 33 (2022) 1933–1935.
4. [4]
  D.K. Soni, R. Ahmad, S.K. Dubey, Crit. Rev. Microbiol. 44 (2018) 590–608. doi: 10.1080/1040841x.2018.1473331
5. [5]
  D. Wang, Q. Chen, H.L. Huo, et al., Food Control 73 (2017) 555–561.
6. [6]
  L. Wang, P.P. Zhao, X.X. Si, et al., Front. Microbiol. 10 (2020) 2959.
7. [7]
  Y. Wang, Y.X. Li, J.L. Yang, J. Ruan, C.J. Sun, Trends Anal. Chem. 78 (2016) 1–16.
8. [8]
  Y.X. Yu, X.H. Sun, Y. Liu, Y.J. Pan, Y. Zhao, Can. J. Microbiol. 61 (2015) 367– 372. doi: 10.1139/cjm-2014-0652
9. [9]
  Y.H. Zhu, Y. Zhao, J.H. Ma, et al., J. Am. Chem. Soc. 139 (2017) 10365–10373. doi: 10.1021/jacs.7b04221
10. [10]
  L.J. Cheng, X. Li, Y.T. Tian, et al., Food Chem. X 19 (2023) 100873.
11. [11]
  Y.C. Tian, D.P. Xu, C. Liu, et al., Mater. Sci. Semicond. Process 137 (2022) 106160.
12. [12]
  X.T. Fang, L.Y. Wang, X. He, J.Q. Xu, Z.M. Duan, Inorg. Chem. 57 (2018) 1689–1692. doi: 10.1021/acs.inorgchem.7b02671
13. [13]
  J.S. Malhotra, M. Kubus, K.S. Pedersen, S.I. Andersen, J. Sundberg, ACS Sens. 8 (2023) 3478–3486. doi: 10.1021/acssensors.3c01058
14. [14]
  S. Chen, X. Duan, C. Liu, et al., J. Hazard. Mater. 467 (2024) 133672.
15. [15]
  J. Zong, Y.S. Zhang, Y. Zhu, et al., Sens. Actuator. B: Chem. 271 (2018) 311–320.
16. [16]
  F. Li, X. Gao, R. Wang, T. Zhang, G.Y. Lu, Sens. Actuator. B: Chem. 248 (2017) 812–819.
17. [17]
  Y. Chen, L.Y. Wang, J.W. Kong, B. Shen, J.Q. Xu, Chin. Chem. Lett. 31 (2020) 2125–2128.
18. [18]
  J.J. Qiu, D.M. Ke, H.C. Lin, et al., Chin. Chem. Lett. 34 (2023) 107391.
19. [19]
  L. Mardiana, A.Y.P. Wardoyo, H.A. Dharmawan Masruroh, Pol. J. Environ. Stud. 32 (2023) 1735–1742. doi: 10.15244/pjoes/159078
20. [20]
  T. Zhao, P.P. Qiu, Y. Fan, et al., Adv. Sci. 6 (2019) 1902008.
21. [21]
  Y. Liu, Y.F. Luo, A.A. Elzatahry, et al., ACS Central Sci. 1 (2015) 400–408. doi: 10.1021/acscentsci.5b00256
22. [22]
  W.H. Yan, W.R. Yan, T.D. Chen, et al., ACS Appl. Nano Mater. 3 (2020) 2545–2553. doi: 10.1021/acsanm.9b02614
23. [23]
  H.F. Zhang, J.Y. Xuan, Q. Zhang, et al., Rare Metals 41 (2022) 3976–3999. doi: 10.1007/s12598-022-02087-x
24. [24]
  X.W. Cheng, L. Huang, X.Y. Yang, et al., J. Colloid Interface Sci. 535 (2019) 425–435.
25. [25]
  Y. Liu, Z.R. Wang, W. Teng, et al., J. Mater. Chem. A 6 (2018) 3162–3170. doi: 10.1039/c7ta10106f
26. [26]
  Y. Yang, Y. Liang, G.Z. Wang, et al., ACS Appl. Mater. Interfaces 7 (2015) 24902–24908. doi: 10.1021/acsami.5b08372
27. [27]
  Y.G. Wang, L.C. Yao, L.J. Xu, et al., Mater. Lett. 302 (2021) 130460.
28. [28]
  W. Chen, Z.H. Wang, S. Gu, et al., Sens. Actuator. B: Chem. 305 (2020) 127476.
29. [29]
  Y.S. Cao, Y. Fan, Z.H. Ma, et al., Sens. Actuator. B: Chem. 273 (2018) 1162– 1169.
30. [30]
  S. Karapati, T. Giannakopoulou, N. Todorova, et al., Appl. Catal. B: Environ. 176 (2015) 578–585.
31. [31]
  F.Y. Song, H. Sun, H.L. Ma, H. Gao, Nanomaterials 12 (2022) 2536. doi: 10.3390/nano12152536
32. [32]
  G.Q. Zhang, H.B. Wu, T. Song, U. Paik, X.W. Lou, Angew. Chem. Int. Ed. 53 (2014) 12590–12593. doi: 10.1002/anie.201406476
33. [33]
  A. Alshehri, K. Narasimharao, J. Mater. Res. Technol. 9 (2020) 14907–14921.
34. [34]
  Y.H. Zhu, H. Li, Q. Zheng, J.Q. Xu, X.X. Li, Langmuir 28 (2012) 7843–7850. doi: 10.1021/la300560j
35. [35]
  A.R. Jimenez, D. Nuñez, N. Rojas, Y. Ramirez, M. Acevedo, ACS Omega 6 (2021) 4932–4938.
36. [36]
  X. Zhao, P. Dai, D.Y. Xu, et al., J. Energy Chem. 59 (2021) 455–464.
37. [37]
  L. Ren, W. Zhu, Y.H. Li, et al., Nano-Micro Lett. 14 (2022) 144.
38. [38]
  K.Y. Chen, W.H. Xie, Y. Deng, et al., ACS Nano 17 (2023) 15763–15775. doi: 10.1021/acsnano.3c03549
39. [39]
  X. Fang, S.B. Wu, Y.H. Wu, et al., Appl. Surf. Sci. 518 (2020) 146226.
40. [40]
  Z.Y. Zhu, L.J. Zheng, S.Z. Zheng, et al., J. Mater. Chem. A 6 (2018) 21419–21427. doi: 10.1039/c8ta08670b
41. [41]
  W. Chen, F.F. Deng, M. Xu, et al., Sens. Actuator. B: Chem. 273 (2018) 498–504.
42. [42]
  S.Q. Xie, C. Zhao, J.B. Shen, et al., ACS Sens. 8 (2023) 728–738. doi: 10.1021/acssensors.2c02257
43. [43]
  Y.H. Zhu, X.H. Dong, J.S. Cheng, et al., Chin. Chem. Lett. 34 (2023) 107930.
44. [44]
  L.Y. Wang, Z.X. Wang, Q. Xiang, et al., Sens. Actuator. B: Chem. 248 (2017) 820–828. doi: 10.1038/onc.2016.250
45. [45]
  H.J. Cai, N. Luo, X.W. Wang, et al., Small 19 (2023) 2302652. doi: 10.1002/smll.20230265
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沈阳化工大学材料科学与工程学院沈阳 110142

Highly selective QCM sensor based on functionalized hierarchical hollow TiO2 nanospheres for detecting ppb-level 3-hydroxy-2-butanone biomarker at room temperature

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通讯作者: 陈斌, bchen63@163.com

Highly selective QCM sensor based on functionalized hierarchical hollow TiO₂ nanospheres for detecting ppb-level 3-hydroxy-2-butanone biomarker at room temperature