Citation: Qihang Wu, Hui Wen, Wenhai Lin, Tingting Sun, Zhigang Xie. Alkyl chain engineering of boron dipyrromethenes for efficient photodynamic antibacterial treatment[J]. Chinese Chemical Letters, ;2024, 35(12): 109692. doi: 10.1016/j.cclet.2024.109692 shu

Alkyl chain engineering of boron dipyrromethenes for efficient photodynamic antibacterial treatment

Qihang Wu ^{a, b} ,
Hui Wen ^{a, b} ,
Wenhai Lin ^{c, *,} ,
Tingting Sun ^{a, *,} ,
Zhigang Xie ^{a, b, *,}

a.
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
b.
School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China
c.
Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China

whlin@suda.edu.cn

suntt@ciac.ac.cn

xiez@ciac.ac.cn

Received Date: 29 December 2023
Revised Date: 4 February 2024
Accepted Date: 29 February 2024
Available Online: 5 March 2024

Figures(6)

Photodynamic therapy has been widely employed as an alternative strategy against bacterial infection. Molecular structure has a profound effect on the antibacterial ability of photosensitizers (PSs). Herein, we designed and synthesized a series of boron dipyrromethene (BODIPY)-based photosensitizers with different alkyl chain lengths, and then their antibacterial activities were compared. Among these BODIPYs, the BODIPY with octyl (BDP-8) exhibits the best antibacterial effect, while the antibacterial performance of BODIPY with dodecyl (BDP-12) is the worst. This work provides instructive information for further development of effective photodynamic antimicrobial agents.
- BODIPY,
- Alkyl chain engineering,
- Photodynamic therapy,
- Antibacterial agent,
- Photosensitizer
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沈阳化工大学材料科学与工程学院沈阳 110142