Citation: Yinglan Yu, Sajid Hussain, Jianping Qi, Lei Luo, Xuemei Zhang. Mechanisms and applications: Cargos transport to basolateral membranes in polarized epithelial cells[J]. Chinese Chemical Letters, ;2024, 35(12): 109673. doi: 10.1016/j.cclet.2024.109673 shu

Mechanisms and applications: Cargos transport to basolateral membranes in polarized epithelial cells

Yinglan Yu ^{a, b} ,
Sajid Hussain ^b ,
Jianping Qi ^{a, *,} ,
Lei Luo ^{b, *,} ,
Xuemei Zhang ^{a, *,}

a.
School of Pharmacy, Fudan University, Shanghai 201203, China
b.
College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China

qijianping@fudan.edu.cn

drluolei@swu.edu.cn

xuemeizhang@fudan.edu.cn

Received Date: 8 January 2024
Revised Date: 20 February 2024
Accepted Date: 22 February 2024
Available Online: 23 February 2024

Figures(4)

In polarized cells, the differential distribution of proteins results in the formation of apical and basolateral membranes. The basolateral membrane contacts basal lamina and mediates cell-to-cell communication, which is crucial for maintaining homeostasis and enabling drug absorption. To establish and maintain the basolateral domain, intricate mechanisms are necessary to ensure the proper sorting and transportation of molecules. Sorting signals play a crucial role in regulating the distributions of basolateral proteins, determining their trafficking route and final residence. Newly synthesized proteins can be segregated into different carrier vesicles at either trans-Golgi network (TGN) or endosomes. Additionally, understanding basolateral transport in polarized epithelial cells is important for predicting diseases and delivering drugs. This review provides a summary of recent advancements in the mechanisms and applications of basolateral sorting and trafficking.
- Polarized cells,
- Basolateral trafficking,
- Sorting signals,
- Disease prediction,
- Drug delivery
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沈阳化工大学材料科学与工程学院沈阳 110142