Citation: Shuheng Zhang, Yuanyuan Zhang, Wanyu Wang, Yuzhu Hu, Xinchuan Chen, Bilan Wang, Xiang Gao. A combination strategy of DOX and VEGFR-2 targeted inhibitor based on nanomicelle for enhancing lymphoma therapy[J]. Chinese Chemical Letters, ;2024, 35(12): 109658. doi: 10.1016/j.cclet.2024.109658 shu

A combination strategy of DOX and VEGFR-2 targeted inhibitor based on nanomicelle for enhancing lymphoma therapy

Shuheng Zhang ^{a, b, 1} ,
Yuanyuan Zhang ^{c, 1} ,
Wanyu Wang ^d ,
Yuzhu Hu ^d ,
Xinchuan Chen ^{e, *,} ,
Bilan Wang ^{a, f, g, *,} ,
Xiang Gao ^d

a.
Department of Pharmacy, West China Second University Hospital of Sichuan University, Chengdu 610041, China
b.
School of Basic Medical Sciences, Henan University, Kaifeng 475004, China
c.
Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China
d.
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China
e.
Department of Hematology, Institute of Hematology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China
f.
Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu 610041, China
g.
Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, China

xinchuan_chen@163.com

bilan@scu.edu.cn

Received Date: 23 October 2023
Revised Date: 12 February 2024
Accepted Date: 15 February 2024
Available Online: 23 February 2024

Figures(5)

Lymphoma is a hematological malignancy with an increasing mortality rate. Nevertheless, the treatment strategy against lymphoma remains limited. Doxorubicin (DOX) is a broad-spectrum anti-tumor chemotherapeutic drug, the clinical application of which is limited by serious adverse effects and drug resistance. In this work, biodegradable methoxy poly(ethylene glycol)-block-poly(lactic acid) (mPEG-PLA) nanomicelles co-delivering of DOX and apatinib (AP) (DOX-AP/m) was developed for lymphoma therapy. The average particle size of the self-assembled drug-loaded nano-micelle was 31.94 nm. It is revealed that AP can enhance the uptake of DOX by tumor cells. The in vivo and in vitro experimental results revealed that DOX-AP/m combination therapy could inhibit proliferation and promote apoptosis of lymphoma cells, and greatly suppress tumor growth. Our study indicated that DOX-AP/m might provide new insight and hold great potential in the treatment of lymphoma.
- Doxorubicin,
- Apatinib,
- Lymphoma,
- Nanomicelle,
- Drug delivery system
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