Citation: Jinyu Guo, Yandai Lin, Shaohua He, Yueqing Chen, Fenglu Li, Renjie Ruan, Gaoxing Pan, Hexin Nan, Jibin Song, Jin Zhang. Utilizing dual-responsive iridium(Ⅲ) complex for hepatocellular carcinoma: Integrating photoacoustic imaging with chemotherapy and photodynamic therapy[J]. Chinese Chemical Letters, ;2024, 35(9): 109537. doi: 10.1016/j.cclet.2024.109537 shu

Utilizing dual-responsive iridium(Ⅲ) complex for hepatocellular carcinoma: Integrating photoacoustic imaging with chemotherapy and photodynamic therapy

Jinyu Guo ^{a, b, 1} ,
Yandai Lin ^{b, 1} ,
Shaohua He ^{d, 1} ,
Yueqing Chen ^{a, b} ,
Fenglu Li ^b ,
Renjie Ruan ^a ,
Gaoxing Pan ^b ,
Hexin Nan ^c ,
Jibin Song ^c ,
Jin Zhang ^{a, b, *,}

a.
Qingyuan Innovation Laboratory, Quanzhou 362801, China
b.
College of Chemical Engineering, Fuzhou University, Fuzhou 350108, China
c.
MOE Key Laboratory for Analytical Science of Food Safety and Biology, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou 350108, China
d.
Department of Pediatric Surgery, Shengli Clinical Medical College of Fujian Medical University, Fuzhou 350001, China

J_zhang929@fzu.edu.cn

Received Date: 8 November 2023
Revised Date: 16 January 2024
Accepted Date: 17 January 2024
Available Online: 20 January 2024

Figures(4)

Stimuli-triggered release and alleviating resistance of iridium(Ⅲ)-based drugs at tumor sites remains challengeable for clinical hepatoma therapy. Herein, a doxorubicin@iridium-transferrin (DOX@Ir-TF) nanovesicle was synthesized by carboxylated-transferrin (TF) and doxorubicin-loaded amphiphilic iridium-amino with quaternary ammonium (QA) groups and disulfide bonds. The QA groups enhanced photophysical properties and broadened production capacity of photoinduced-reactive oxygen species (ROS), while the disulfide-bridged bonds regulated oxidative stress levels through reacting with glutathione (GSH); simultaneously, modification of TF improved recognition and endocytosis of the nanovesicle for tumor cells. Based on in-vitro results, a controlled-release behavior of DOX upon a dual-responsiveness of GSH and near-infrared ray (NIR) irradiation was presented, along with high-efficiency generation of ROS. After an intravenous injection, the nanovesicle was targeted at tumor sites, realizing TF-navigated photoacoustic imaging guidance and synergistic chemotherapy-photodynamic therapy under NIR/GSH stimulations. Overall, newly-synthesized DOX@Ir-TF nanovesicle provided a potential in subcutaneous hepatocellular carcinoma therapy due to integrations of targeting delivery, dual-stimuli responsive release, synergistic therapy strategy, and real-time monitoring.
- Amphiphilic iridium complex,
- Transferrin targeting,
- NIR/GSH dual-responsiveness,
- Photoacoustic imaging,
- Synergistic tumor therapy
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