Citation: Shehla Khalid, Muhammad Bilal, Nasir Rasool, Muhammad Imran. Photochemical reactions as synthetic tool for pharmaceutical industries[J]. Chinese Chemical Letters, ;2024, 35(9): 109498. doi: 10.1016/j.cclet.2024.109498 shu

Photochemical reactions as synthetic tool for pharmaceutical industries

a.
Department of Chemistry, Government College University, Faisalabad 38000, Pakistan
b.
School of Chemistry and Chemical Engineering, Shandong University, Ji'nan 250100, China
c.
Department of Chemistry, Faculty of Science, King Khalid University, Abha 61413, Saudi Arabia

Author Bio: Shehla Khalid received her Bachelor's degree from Government College University, Faisalabad. She completed her master's degree under the supervision of Prof. Nasir Rasool from the same institute. Her research interest focuses on transition metal catalyzed reactions, chemistry of heterocycles, photo/electrochemical reactions, bio-active molecules synthesis, coupling reactions, inert bonds activation and functionalization
Muhammad Bilal received his Bachelor's and Master's degrees from Government College University, Faisalabad, under the supervision of Prof. Nasir Rasool. Then, he joined Higher Education Department Pakistan as a Lecturer of Chemistry. Now, he is doing Ph.D. as a CSC fellow under the supervision of Prof. Yu-Feng Liang at Shandong University, China. Currently, his doctoral research focuses on cross coupling reactions using electrochemistry or earth-abundant transition metals and ring-opening reactions
Nasir Rasool was born in Chichawatni, Sahiwal, Pakistan. He received his MSc. degree from Bahauddin Zakariya University Multan. Later he joined Prof Dr Peter Langer at the institute of Chemistry, University of Rostock, Germany as PhD research fellow. Then he joined Government College University Faisalabad as an Assistant Professor. He has published more than 200 research articles and supervised number of graduate, post graduate and PhD students. He received research productivity awards from Pakistan council of science and technology several times. His-current research focuses on synthesis of small drug molecules, cross-coupling reactions and synthesis of organic solar cells and theoretical studies. Now, he is working as a Professor of Chemistry at Department of Chemistry GC University, Faisalabad, Pakistan
Muhammad Imran completed his graduation in Chemistry from the University of Agriculture, Faisalabad, Pakistan and obtained his PhD degree from International Center for Chemical and Biological Science, University of Karachi, Pakistan in 2009. Then he joined Higher Education Department Lahore, Pakistan as Assistant Professor in 2009. He worked as a post-doc researcher at University of Sao Paulo Brazil in 2011 and at University of Bristol UK in 2017. His-research interest focused on biologically active natural, synthetic products, functional nanomaterials, and first principle investigations. At present, he is working as Associate professor of organic chemistry at King Khalid University, Abha, Saudi Arabia

nasirrasool@gcuf.edu.pk

Received Date: 1 October 2023
Revised Date: 22 December 2023
Accepted Date: 2 January 2024
Available Online: 6 January 2024

Figures(55)

In the quest for new agrochemicals and pharmaceuticals, chemists seek access to reliable and mild synthetic techniques to allow for the systematic modification of chemical structures, exploration of unexplored chemical space, and facilitation of practical synthesis in their search for novel agrochemicals and pharmaceuticals. In this regard, photocatalytic reactions enabled the synthesis of intricate and more functionalized compounds. This review overviews the developed synthetic methodologies and their utility in the chemical synthesis of pharmaceuticals. This review also offers in-depth insights into contemporary photoredox reactions such as allylic additions, cyclization, reductive cross-coupling, CH activation, ring opening, oxidative cross-coupling, dehydrogenation, desulphonation, and decarboxylation. It provides a positive outlook for the promising future of this field.
- Photocatalyst,
- Photochemical reactions,
- Drugs,
- Natural products,
- Late-stage functionalization
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