Citation: Jinjie Lu, Qikai Liu, Yuting Zhang, Yi Zhou, Yanbo Zhou. Antibacterial performance of cationic quaternary phosphonium-modified chitosan polymer in water[J]. Chinese Chemical Letters, ;2024, 35(9): 109406. doi: 10.1016/j.cclet.2023.109406 shu

Antibacterial performance of cationic quaternary phosphonium-modified chitosan polymer in water

State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, East China University of Science and Technology, Shanghai 200237, China

zhouyanbo@ecust.edu.cn

Received Date: 14 September 2023
Revised Date: 5 December 2023
Accepted Date: 18 December 2023
Available Online: 19 December 2023

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Microbial contamination in water has emerged as a critical concern and thus developing biocide materials for controlling microbial contamination is crucial. Removing all pathogenic bacteria in water is difficult when using traditional water treatment technologies. Moreover, these bacteria can easily reproduce during pipeline distribution. In this work, a facile and effective chitosan derivative biocide denoted as PCC was developed by grafting with quaternary phosphonium salt (QPS). PCC became positively charged with a wide range of pH and demonstrated antibacterial activity up to 95% and 100% against Escherichia coli and Staphylococcus aureus as model pathogens, respectively. The grafting of QPS may disrupt the cell membrane and lead to bacterial inactivation, as demonstrated by the scanning electron microscopy image and the concentration of intracellular substance leakage. MTT assay results indicate that PCC achieved good biocompatibility with negligible in vitro cytotoxicity. These findings introduce a promising approach for bacterial decontamination due to its low cytotoxicity and high biocidal activity.
- Chitosan,
- Quaternary phosphonium salt,
- Antibacterial performance,
- Antibacterial mechanism,
- Morphology change
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