Citation: Zhigang Zeng, Changzhou Liao, Lei Yu. Molecules for COVID-19 treatment[J]. Chinese Chemical Letters, ;2024, 35(7): 109349. doi: 10.1016/j.cclet.2023.109349 shu

Molecules for COVID-19 treatment

Zhigang Zeng ^{a, b, *,} ,
Changzhou Liao ^{a, b} ,
Lei Yu ^{c, *,}

a.
Hubei Key Laboratory of Radiation Chemistry and Functional Materials, School of Nuclear Technology and Chemistry & Biology, Hubei University of Science and Technology, Xianning 437100, China
b.
Hubei Industry Technology Research Institute of Intelligent Health, Xianning 437100, China
c.
School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China

Author Bio: Zhigang Zeng is now an associate professor at Hubei University of Science and Technology and a senior research fellow at Hubei Huisheng Pharmaceutical Co., Ltd., China. His current research interest focuses on the drug research and development, organic synthesis methodologies including the related applications in green synthesis, (bio)catalysis

Lei Yu received his B.Sc. from Nanjing University (2003). He received his Ph.D. from Zhejiang University under the direction of academician Xian Huang (2008). He conducted postdoctoral research at Yangzhou University (2008–2011) and Jiangsu Yangnong Chemical Group Company Limited/Nanjing University (2011–2013) respectively. He visited Prof. Mark Lautens' group at the University of Toronto (2013–2014) as a visiting scholar. He is now a professor at Yangzhou University. He is the head of the joint-laboratory of Shanghai Dingya Pharmaceutical Chemical Technology Co., Ltd. with Yangzhou University. He has published over 190 papers and the H-index is currently 43. He obtained over 40 authorized invention patents, including 4 times of assignment of the patent right and one time license for enterprise use; He created economic benefits with an annual output value exceeding 1 billion yuan (ca. ＄ 0.14 billion). His-current research interest is on element chemistry including the related applications on green synthesis, catalysis and novel materials development. For more information, please see the personal homepage at: http://teacher.yzu.edu.cn/YL123/zh_CN/index.htm

zzgang@hbust.edu.cn

yulei@yzu.edu.cn

Received Date: 27 August 2023
Revised Date: 14 November 2023
Accepted Date: 27 November 2023
Available Online: 2 December 2023

Figures(11)

COVID-19 is a major event with worldwide influences. Since the beginning of the epidemic, pharmaceutical chemists have paid attention to the therapeutic effect of a variety of small molecule medicines on COVID-19 infection. A series of organic molecules are designed and found to be effective in the treatment of COVID-19 infection. In fact, no matter how effective they are, with the development of the COVID-19 epidemic, various small molecule medicines are gradually recognized by people. This is equivalent to a good science popularization of pharmaceutical chemistry. This review aims to introduce the molecules for COVID-19 treatment on the basis of their chemical structures, synthetic methods as well as their effects.
- COVID-19,
- Small molecule medicines,
- "Star" drugs,
- Chemical structure,
- Synthetic method
1. [1]
  W.J. Wiersinga, A. Rhodes, A.C. Cheng, S.J. Peacock, H.C. Prescott, JAMA 324 (2020) 782–793. doi: 10.1001/jama.2020.12839
2. [2]
  X. Xu, P. Chen, J. Wang, et al., Sci. China Life Sci. 63 (2020) 457–460. doi: 10.1007/s11427-020-1637-5
3. [3]
  M. Hoenigl, D. Abramovitz, R.E. Flores Ortega, N.K. Martin, N. Reau, Clin. Infect. Dis. 75 (2022) e955–e961. doi: 10.1093/cid/ciac175
4. [4]
  J. Zhang, B. Xie, K. Hashimoto, Brain Behav. Immun. 87 (2020) 59–73. doi: 10.1016/j.bbi.2020.04.046
5. [5]
  T.C. Liu, S.M. Yoo, M.S. Sim, et al., JAMA Netw. Open 6 (2023) e2311974. doi: 10.1001/jamanetworkopen.2023.11974
6. [6]
  J.M. Perry, F. Tao, A. Roy, et al., Nat. Cell Biol. 22 (2020) 689–700. doi: 10.1038/s41556-020-0507-y
7. [7]
  N. Mast, P. Verwilst, C.J. Wilkey, F.P. Guengerich, I.A. Pikuleva, J. Med. Chem. 63 (2020) 6477–6488. doi: 10.1021/acs.jmedchem.9b01383
8. [8]
  H. Beck, M. Härter, B. Haß, C. Schmeck, L. Baerfacker, Drug Discov. Today 27 (2022) 1560–1574. doi: 10.1016/j.drudis.2022.02.015
9. [9]
  Y. Yang, L. Du, Sig. Transduct, Target. Ther. 6 (2021) 95.
10. [10]
  S. Lei, X. Chen, J. Wu, X. Duan, K. Men, Sig. Transduct. Target. Ther. 7 (2022) 387. doi: 10.1038/s41392-022-01249-8
11. [11]
  D. Tian, Y. Liu, C. Liang, et al., Biomed. Pharmacother. 137 (2021) 111313. doi: 10.1016/j.biopha.2021.111313
12. [12]
  W.S. Ho, R. Zhang, Y.L. Tan, C.L.L. Chai, Pharmacol. Res. 179 (2022) 106201. doi: 10.1016/j.phrs.2022.106201
13. [13]
  D. Li, J. Hu, D. Li, et al., Top. Curr. Chem. 379 (2021) 4. doi: 10.1007/s41061-020-00318-2
14. [14]
  L. Zhong, Z. Zhang, X. Peng, J. Zou, S. Yang, Precis. Clin. Med. 5 (2022) pbac024. doi: 10.1093/pcmedi/pbac024
15. [15]
  A.C. Puhl, T.R. Lane, F. Urbina, S. Ekins, Front. Drug Discov. 2 (2022) 837587. doi: 10.3389/fddsv.2022.837587
16. [16]
  D.C. Blakemore, L. Castro, I. Churcher, et al., Nat. Chem. 10 (2018) 383–394. doi: 10.1038/s41557-018-0021-z
17. [17]
  K.R. Campos, P.J. Coleman, J.C. Alvarez, et al., Science 363 (2019) eaat0805. doi: 10.1126/science.aat0805
18. [18]
  D. Siegel, H.C. Hui, E. Doerffler, et al., J. Med. Chem. 60 (2017) 1648–1661. doi: 10.1021/acs.jmedchem.6b01594
19. [19]
  M.G. Santoro, E. Carafoli, Biochem. Biophys. Res. Commun. 538 (2021) 145–150. doi: 10.1016/j.bbrc.2020.11.043
20. [20]
  W. Yin, C. Mao, X. Luan, et al., Science 368 (2020) 1499–1504.
21. [21]
  WHO BMJ 371 (2020) m4475, doi:10.1136/bmj.m4475. doi: 10.1136/bmj.m4475
22. [22]
  D.J. Paymode, N. Vasudevan, S. Ahmad, et al., Org. Process Res. Dev. 25 (2021) 1822–1830. doi: 10.1021/acs.oprd.1c00033
23. [23]
  V. Gopalsamuthiram, C. Williams, J. Noble, et al., Synlett 32 (2021) 326–328. doi: 10.1055/a-1275-2848
24. [24]
  G.P. Ahlqvist, C.P. McGeough, C. Senanayake, et al., ACS Omega 6 (2021) 10396–10402. doi: 10.1021/acsomega.1c00772
25. [25]
  T. Hu, Y. Xie, Y. Liu, et al., ChemRxiv (2021), doi: 10.26434/chemrxiv.14208206.v1.
26. [26]
  G.R. Painter, D.B. Guthrie, G.R. Bluemling, et al., Patent: WO2019113462A1, 2019.
27. [27]
  A. Steiner, D. Znidar, S.B. Ötvös, et al., Eur. J. Org. Chem. 2020 (2020) 6736–6739. doi: 10.1002/ejoc.202001340
28. [28]
  T. Benkovics, J.A. Mcintosh, S.M. Silverman, et al., ChemRxiv (2020), doi: 10.26434/chemrxiv.13472373.v1.
29. [29]
  H. Chen, Y. Lin, Z. Wang, et al., Patent: CN114560894B, 2023.
30. [30]
  S.M.R. Hashemian, M.H. Pourhanifeh, M.R. Hamblin, M.K. Shahrzad, H. Mirzaei, Biomed. Pharmacother. 146 (2022) 112517. doi: 10.1016/j.biopha.2021.112517
31. [31]
  A. Jayk Bernal, M.M. Gomes da Silva, D.B. Musungaie, et al., New Engl. J. Med. 386 (2021) 509–520.
32. [32]
  S. Venkatraman, S.L. Bogen, A. Arasappan, et al., J. Med. Chem. 49 (2006) 6074–6086. doi: 10.1021/jm060325b
33. [33]
  R. Zhang, A. Mamai, J.S. Madalengoitia, J. Org. Chem. 64 (1999) 547–555. doi: 10.1021/jo9816109
34. [34]
  J. Park, A. Sudhakar, G.S. Wong, et al., Patent: WO2004113295A1, 2004.
35. [35]
  G. Wu, F.X. Chen, P. Rashatasakhon, et al., Patent: WO2007075790A1, 2007.
36. [36]
  H. Togo, S. Iida, Synlett 2006 (2006) 2159–2175. doi: 10.1055/s-2006-950405
37. [37]
  S.R. Kallam, V.R. Eda, S. Sen, et al., Tetrahedron 73 (2017) 4285–4294. doi: 10.1016/j.tet.2017.05.080
38. [38]
  D.R. Owen, C.M.N. Allerton, A.S. Anderson, et al., Science 374 (2021) 1586–1593. doi: 10.1126/science.abl4784
39. [39]
  Y. Zhao, C. Fang, Q. Zhang, et al., Protein Cell 13 (2021) 689–693.
40. [40]
  E. Mahase, BMJ 375 (2021) n2713, doi:10.1136/bmj.n2713. doi: 10.1136/bmj.n2713
41. [41]
  J.B. Chang, Bull. Natl. Nat. Sci. Found China 36 (2022) 630–634.
42. [42]
  Y. Furua, H. Egawa, Patent: WO2000010569A1, 2000.
43. [43]
  T. Hara, N. Norimatsu, H. Kurushima, et al., Patent: WO2010087117A1, 2010.
44. [44]
  S. Tsuzuki, K. Hayakawa, Y. Doi, et al., Infect. Dis. Ther. 11 (2022) 1075–1087. doi: 10.1007/s40121-022-00617-9
45. [45]
  K. Shiraki, N. Sato, K. Sakai, et al., Pharmacol. Ther. 235 (2022) 108121. doi: 10.1016/j.pharmthera.2022.108121
46. [46]
  H.A. Erdem, P.E. Korkma, D. Çağlayan, et al., Turk. J. Med. Sci. 51 (2021) 912–920. doi: 10.3906/sag-2008-33
47. [47]
  J.B. Chang, X.H. Bao, Q. Wang, et al., Patent: CN101177442A, 2008.
48. [48]
  J.B. Chang, Patent: EP2177527B1, 2013.
49. [49]
  J.B. Chang, Patent: US8835615B2, 2014.
50. [50]
  Q. Wang, W.D. Hu, S.Y. Wang, et al., Eur. J. Med. Chem. 46 (2011) 4178–4183. doi: 10.1016/j.ejmech.2011.06.020
51. [51]
  J.B. Chang, Acc. Chem. Res. 55 (2022) 565–578. doi: 10.1021/acs.accounts.1c00697
52. [52]
  J.L. Zhang, Y.H. Li, L.L. Wang, et al., Sig. Transduct. Target. Ther. 6 (2021) 414. doi: 10.1038/s41392-021-00835-6
53. [53]
  Z.G. Ren, H. Luo, Z.J. Yu, et al., Adv. Sci. 7 (2020) e2001435. doi: 10.1002/advs.202001435
54. [54]
  B. Yu, J.B. Chang, Sig. Transduct. Target. Ther. 5 (2020) 236. doi: 10.1038/s41392-020-00351-z
55. [55]
  W. Li, M. Xiao, J. Dalton, et al., Patent: US20200024270A1, 2020.
56. [56]
  E.J. Rubin, L.R. Baden, C.C. Hardin, S. Morrissey, New Engl. J. Med. 387 (2022) e51.
57. [57]
  Anna Bratulic, https://firstwordpharma.com/story/5545887 (accessed April 11, 2022).
58. [58]
  Veru, https://ir.verupharma.com/news-events/press-releases/detail/152/veruannounces-presentation-of-phase-3-study-of-sabizabulin (accessed August 9, 2022).
59. [59]
  Y.Z. Tong, Patent: WO2012119559A1, 2012.
60. [60]
  X.D. Hou, H.H. Yan, A. Wang, et al., BioRxiv (2022), doi: 10.1101/2022.06.29.498191.
61. [61]
  F.A. Cadegiani, J. McCoy, C.G. Wambier, et al., Cureus 13 (2021) e13492.
62. [62]
  F.A. Cadegiani, R.A. Zimerman, D.N. Fonseca, et al., Cureus 13 (2021) e20691.
63. [63]
  O.T. Ranzani, L.S.L. Bastos, J.G.M. Gelli, et al., Lancet Respir. Med. 9 (2021) 407–418. doi: 10.1016/S2213-2600(20)30560-9
64. [64]
  Y. Unoh, S. Uehara, K. Nakahara, et al., J. Med. Chem. 65 (2022) 6499–6512. doi: 10.1021/acs.jmedchem.2c00117
65. [65]
  Shionogi, https://www.shionogi.com/global/en/news/2022/2/22-0225.html (accessed February 25, 2022).
66. [66]
  Shionogi, https://www.shionogi.com/global/en/news/2022/03/e-20220316-2.html (accessed March 15, 2022).
67. [67]
  Shionogi, https://www.pingan-shionogi.cn/en/2022/07/04/ping-an-shionogiinitiates-the-submission-of-the-preparation-materia-ls-for-new-drugapplication-for-s-217622-a-therapeutic-drug-for-covid-19-in-china/(accessed July 4, 2022).
68. [68]
  Shionogi, https://www.shionogi.com/global/en/news/2022/2/e-20220207.html (accessed February 7, 2022).
69. [69]
  Z.T. Al-Salama, L.J. Scott, Drugs 78 (2018) 761–772. doi: 10.1007/s40265-018-0908-4
70. [70]
  J.D. Rodgers, S. Shepard, Y.L. Li, et al., Patent: WO2009114512A1, 2009.
71. [71]
  E.W. Ely, A.V. Ramanan, C.E. Kartman, et al., Lancet Respir. Med. 10 (2022) 327–336. doi: 10.1016/S2213-2600(22)00006-6
72. [72]
  A.C. Kalil, T.F. Patterson, A.K. Mehta, et al., New Engl. J. Med. 384 (2021) 795–807. doi: 10.1056/NEJMoa2031994
73. [73]
  M. Saber-Ayad, S. Hammoudeh, E. Abu-Gharbieh, et al., Pharmaceuticals 14 (2021) 680. doi: 10.3390/ph14070680
74. [74]
  R. Rubin, JAMA 327 (2022) 2281, doi:10.1001/jama.2022.9846. doi: 10.1001/jama.2022.9846
75. [75]
  J.P. Sommadossi, A. Moussa, Patent: US20210009628A1, 2021.
76. [76]
  Atea Pharmaceuticals, https://ir.ateapharma.com/news-releases/news-releasedetails/atea-pharmaceuticals-announces-first-patient-dosed-sunrise-3 (accessed November 29, 2022).
77. [77]
  A. Shannon, V. Fattorini, B. Sama, et al., Nat. Commun. 13 (2022) 621. doi: 10.1038/s41467-022-28113-1
78. [78]
  E. Berliba, M. Bogus, F. Vanhoutte, et al., Antimicrob. Agents Chemother. 63 (2019) e01201.
79. [79]
  Pardes Biosciences, https://ir.pardesbio.com/news-releases/news-releasedetails/pardes-biosciences-and-fs-development-corp-ii-announce-merger (accessed June 29, 2021).
80. [80]
  L.D. Arnold, A. Jennings, W. Keung, Patent: GB2595975A, 2021.
81. [81]
  Pardes Biosciences, https://ir.pardesbio.com/news-releases/news-releasedetails/pardes-biosciences-announces-fda-clearance-ind-application-pbi (accessed February 3, 2022).
82. [82]
  Pardes Biosciences, https://www.globenewswire.com/news-release/2022/02/14/2384315/0/en/Pardes-Biosciences-Presents-Interim-Clinical-Data-fromOngoing-PBI-0451-Phase-1-Trial-Supporting-the-Potential-of-PBI-0451-as-aStand-Alone-Oral-Regimen-for-COVID-19-at-Conference-.html (accessed February 14, 2022).
83. [83]
  Pardes Biosciences, https://ir.pardesbio.com/news-releases/news-releasedetails/pardes-biosciences-announces-commencement-phase-2-trial (accessed September 13, 2022).
84. [84]
  WHO, https://covid19.who.int/(accessed June 7, 2023).
85. [85]
  S. Khatiwada, A. Subedi, Curr. Nutr. Rep. 10 (2021) 125–136. doi: 10.1007/s13668-021-00354-4
86. [86]
  L.M. Xian, Q.R. Li, T. Li, et al., Chin. Chem. Lett. 34 (2023) 107878. doi: 10.1016/j.cclet.2022.107878
87. [87]
  X.R. Xiao, Z.F. Shao, L. Yu, Chin. Chem. Lett. 32 (2021) 2933–2938. doi: 10.1016/j.cclet.2021.03.047
88. [88]
  Q.Y. Wang, P.Z. Li, T. Li, et al., Ind. Eng. Chem. Res. 60 (2021) 8659–8663. doi: 10.1021/acs.iecr.1c01437
89. [89]
  W.Q. Ding, S. Wang, J.X. Gu, et al., Chin. Chem. Lett. 34 (2023) 108043. doi: 10.1016/j.cclet.2022.108043
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2. [2]
  Ao Sun , Zipeng Li , Shuchun Li , Xiangbao Meng , Zhongtang Li , Zhongjun Li . Stereoselective synthesis of α-3-deoxy-D-manno-oct-2-ulosonic acid (α-Kdo) derivatives using a C3-p-tolylthio-substituted Kdo fluoride donor. Chinese Chemical Letters, 2025, 36(3): 109972-. doi: 10.1016/j.cclet.2024.109972
3. [3]
  Ali Dai , Zhiguo Zheng , Liusheng Duan , Jian Wu , Weiming Tan . Small molecule chemical scaffolds in plant growth regulators for the development of agrochemicals. Chinese Chemical Letters, 2025, 36(4): 110462-. doi: 10.1016/j.cclet.2024.110462
4. [4]
  Yunjie Dang , Yanru Feng , Xiao Chen , Chaoxing He , Shujie Wei , Dingyang Liu , Jinlong Qi , Huaxing Zhang , Shaokun Yang , Zhiyun Niu , Bai Xiang . Development of a multi-level pH-responsive lipid nanoplatform for efficient co-delivery of siRNA and small-molecule drugs in tumor treatment. Chinese Chemical Letters, 2024, 35(12): 109660-. doi: 10.1016/j.cclet.2024.109660
5. [5]
  Ying Li , Long-Jie Wang , Yong-Kang Zhou , Jun Liang , Bin Xiao , Ji-Shen Zheng . An improved installation of 2-hydroxy-4-methoxybenzyl (iHmb) method for chemical protein synthesis. Chinese Chemical Letters, 2024, 35(5): 109033-. doi: 10.1016/j.cclet.2023.109033
6. [6]
  Kun Zhang , Ni Dan , Dan-Dan Ren , Ruo-Yu Zhang , Xiaoyan Lu , Ya-Pan Wu , Li-Lei Zhang , Hong-Ru Fu , Dong-Sheng Li . A small D-A molecule with highly heat-resisting room temperature phosphorescence for white emission and anti-counterfeiting. Chinese Journal of Structural Chemistry, 2024, 43(3): 100244-100244. doi: 10.1016/j.cjsc.2024.100244
7. [7]
  Aolei Tan , Xiaoxiao Ma . Exploring the functional roles of small-molecule metabolites in disease research: Recent advancements in metabolomics. Chinese Chemical Letters, 2024, 35(8): 109276-. doi: 10.1016/j.cclet.2023.109276
8. [8]
  Brandon Bishop , Shaofeng Huang , Hongxuan Chen , Haijia Yu , Hai Long , Jingshi Shen , Wei Zhang . Artificial transmembrane channel constructed from shape-persistent covalent organic molecular cages capable of ion and small molecule transport. Chinese Chemical Letters, 2024, 35(11): 109966-. doi: 10.1016/j.cclet.2024.109966
9. [9]
  Qian Wang , Yeping Bian , Gagan Dhawan , Wei Zhang , Alexander E. Sorochinsky , Ata Makarem , Vadim A. Soloshonok , Jianlin Han . FDA approved fluorine-containing drugs in 2023. Chinese Chemical Letters, 2024, 35(11): 109780-. doi: 10.1016/j.cclet.2024.109780
10. [10]
  Yingjie Wang , Peng Tang , Wenchao Tu , Qi Gao , Cuizhu Wang , Luying Tan , Lixin Zhao , Hongye Han , Liefeng Ma , Kouharu Otsuki , Weilie Xiao , Wenli Wang , Jinping Liu , Yong Li , Zhajun Zhan , Wei Li , Xianli Zhou , Ning Li . Highly anticipated natural diterpenoids as an important source of new drugs in 2013–2023. Chinese Chemical Letters, 2025, 36(1): 109955-. doi: 10.1016/j.cclet.2024.109955
11. [11]
  Shehla Khalid , Muhammad Bilal , Nasir Rasool , Muhammad Imran . Photochemical reactions as synthetic tool for pharmaceutical industries. Chinese Chemical Letters, 2024, 35(9): 109498-. doi: 10.1016/j.cclet.2024.109498
12. [12]
  Zhiwei Zhong , Yanbin Huang , Wantai Yang . A simple photochemical method for surface fluorination using perfluoroketones. Chinese Chemical Letters, 2024, 35(5): 109339-. doi: 10.1016/j.cclet.2023.109339
13. [13]
  Yujie Li , Ya-Nan Wang , Yin-Gen Luo , Hongcai Yang , Jinrui Ren , Xiao Li . Advances in synthetic biology-based drug delivery systems for disease treatment. Chinese Chemical Letters, 2024, 35(11): 109576-. doi: 10.1016/j.cclet.2024.109576
14. [14]
  Xueling Yu , Lixing Fu , Tong Wang , Zhixin Liu , Na Niu , Ligang Chen . Multivariate chemical analysis: From sensors to sensor arrays. Chinese Chemical Letters, 2024, 35(7): 109167-. doi: 10.1016/j.cclet.2023.109167
15. [15]
  Tiantian Long , Hongmei Luo , Jingbo Sun , Fengniu Lu , Yi Chen , Dong Xu , Zhiqin Yuan . Carbonization-engineered ultrafast chemical reaction on nanointerface. Chinese Chemical Letters, 2025, 36(3): 109728-. doi: 10.1016/j.cclet.2024.109728
16. [16]
  Erzhuo Cheng , Yunyi Li , Wei Yuan , Wei Gong , Yanjun Cai , Yuan Gu , Yong Jiang , Yu Chen , Jingxi Zhang , Guangquan Mo , Bin Yang . Galvanostatic method assembled ZIFs nanostructure as novel nanozyme for the glucose oxidation and biosensing. Chinese Chemical Letters, 2024, 35(9): 109386-. doi: 10.1016/j.cclet.2023.109386
17. [17]
  Keyang Li , Yanan Wang , Yatao Xu , Guohua Shi , Sixian Wei , Xue Zhang , Baomei Zhang , Qiang Jia , Huanhua Xu , Liangmin Yu , Jun Wu , Zhiyu He . Flash nanocomplexation (FNC): A new microvolume mixing method for nanomedicine formulation. Chinese Chemical Letters, 2024, 35(10): 109511-. doi: 10.1016/j.cclet.2024.109511
18. [18]
  Wenxuan Yang , Long Shang , Xiaomeng Liu , Sihan Zhang , Haixia Li , Zhenhua Yan , Jun Chen . Ultrafast synthesis of nanocrystalline spinel oxides by Joule-heating method. Chinese Chemical Letters, 2024, 35(11): 109501-. doi: 10.1016/j.cclet.2024.109501
19. [19]
  Chen Chen , Jinzhou Zheng , Chaoqin Chu , Qinkun Xiao , Chaozheng He , Xi Fu . An effective method for generating crystal structures based on the variational autoencoder and the diffusion model. Chinese Chemical Letters, 2025, 36(4): 109739-. doi: 10.1016/j.cclet.2024.109739
20. [20]
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