Citation: Gongcheng Ma, Qihang Ding, Yuding Zhang, Yue Wang, Jingjing Xiang, Mingle Li, Qi Zhao, Saipeng Huang, Ping Gong, Jong Seung Kim. Palladium-free chemoselective probe for in vivo fluorescence imaging of carbon monoxide[J]. Chinese Chemical Letters, ;2024, 35(9): 109293. doi: 10.1016/j.cclet.2023.109293 shu

Palladium-free chemoselective probe for in vivo fluorescence imaging of carbon monoxide

Gongcheng Ma ^{a, b, 1} ,
Qihang Ding ^{c, 1} ,
Yuding Zhang ^{a, d, 1} ,
Yue Wang ^{a, e, 1} ,
Jingjing Xiang ^a ,
Mingle Li ^f ,
Qi Zhao ^{e, *,} ,
Saipeng Huang ^{d, *,} ,
Ping Gong ^{a, b, *,} ,
Jong Seung Kim ^{c, *,}

a.
Guangdong Key Laboratory of Nanomedicine, Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations, CAS-HK Joint Lab for Biomaterials, Research Laboratory for Biomedical Optics and Molecular Imaging, Shenzhen Key Laboratory for Molecular Imaging, CAS Key Lab for Health Informatics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
b.
University of Chinese Academy of Sciences, Beijing 100049, China
c.
Department of Chemistry, Korea University, Seoul 02841, South Korea
d.
School of Chemical Engineering, Northwest University, Xi'an 710069, China
e.
Cancer Center, Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau 999078, China
f.
State Key Laboratory of Fine Chemicals, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China

qizhao@umac.mo

huangsaipeng@nwu.edu.cn

ping.gong@siat.ac.cn

jongskim@korea.ac.kr

Received Date: 11 September 2023
Revised Date: 8 November 2023
Accepted Date: 9 November 2023
Available Online: 11 November 2023

Figures(5)

Carbon monoxide (CO) is a vital intracellular gas messenger known for its cytoprotective and homeostatic properties. It plays a pivotal role in a myriad of biological processes. Therefore, the precise detection of CO is of paramount importance in unraveling the intricacies of pathological mechanisms and advancing the development of disease diagnosis. We herein introduce NFCOP, a state-of-the-art near-infrared (NIR) turn-on fluorescence (FL) probe that has been meticulously designed for highly sensitive, swift and selective imaging of CO. The NFCOP response occurred rapidly with CO, within just 10 s, and the calculated detection limit for CO was determined to be 0.32 µmol/L. Further investigations conducted at the cellular level and in vivo demonstrated that NFCOP possesses high sensitivity and selectivity for imaging CO.
- Palladium-free,
- Chemoselective probe,
- Fluorescence imaging,
- Carbon monoxide,
- Near-infrared
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