Citation: Selvaraj Muthusamy, Kanagaraj Rajalakshmi, Palanisamy Kannan, Yun-Sik Nam, Dongwei Zhu, Yeonggil Seo, Jong-Won Song, Dong Nyoung Heo, Il Keun Kwon, Yuanguo Xu. Quantitative detection of citrate for early stage diagnosing of prostate cancer: Discriminating normal to cancer in prostate tissues[J]. Chinese Chemical Letters, ;2024, 35(2): 108880. doi: 10.1016/j.cclet.2023.108880 shu

Quantitative detection of citrate for early stage diagnosing of prostate cancer: Discriminating normal to cancer in prostate tissues

a.
School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China
b.
College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001, China
c.
Advanced Analysis Center, Korea Institute of Science & Technology, Seongbuk-gu, Seoul 02792, Republic of Korea
d.
School of Medicine, Jiangsu University, Zhenjiang 212013, China
e.
Department of Chemistry Education, Daegu University, Gyeongsan-si, Gyeongsangbuk-do 38453, Republic of Korea
f.
Department of Dental Materials, School of Dentistry, Kyung Hee University, Seoul, Republic of Korea

rajselva311@ujs.edu.cn

ktpkannan@zjxu.edu.cn

xuyg@ujs.edu.cn

Received Date: 31 January 2023
Revised Date: 19 July 2023
Accepted Date: 1 August 2023
Available Online: 5 August 2023

Figures(8)

Prostate cancer (PC) biomarker-citrate detection is clinically important to diagnose PC in early stages. Methylquinolinium iodide (Q) conjugated indole-phenylboronic acid (IB) was designed as a red-emissive QIB probe for the detection of citrate through Lewis acid–base reaction and intramolecular charge transfer (ICT) sensing mechanisms. Boronic acid acts as Lewis acid as well as citrate (Lewis base) recognition unit. The probe reacted with citrate, showing enhanced red emissions. Since the probe has excellent water solubility and great biocompatibility, practical application in biological systems is possible. Citrate was monitored precisely in the mitochondria organelle (in vitro) of living cells with a positive charge on QIB. Also, endogenous (in situ) citrate was detected quantitatively to discriminate non-cancerous and PC mice, observed strong and lower (negligible) emission intensity on non-cancerous and cancerous prostate tissues, respectively. Because, the concentration of citrate is higher in healthy prostate compared with PC prostate. Furthermore, the analysis of sliced prostate tissues can give PC-related information for clinical diagnosis to prevent and treat PC in the initial stages. Therefore, we believe that the present probe is a promising biochemical reagent in diagnosing PC.
- Prostate cancer,
- Biomarker-citrate,
- Boronic acid,
- Lewis acid/base-ICT,
- Red-emissive,
- Mitochondria targeting,
- Prostate tissue
1. [1]
  S. Muthusamy, K. Rajalakshmi, P. Kannan, et al., Sens. Actuator. B: Chem. 369 (2022) 132299. doi: 10.1016/j.snb.2022.132299
2. [2]
  K. Rajalakshmi, Y.S. Nam, M. Selvaraj, et al., Sens. Actuator. B: Chem. 259 (2018) 90–96. doi: 10.1016/j.snb.2017.12.047
3. [3]
  S. Mishra, E.S. Kim, P.K. Sharma, et al., ACS Appl. Bio. Mater. 3 (2020) 7821–7830. doi: 10.1021/acsabm.0c01002
4. [4]
  S. Bhagat, S. Singh, ACS Appl. Bio. Mater. 3 (2020) 3999–4011. doi: 10.1021/acsabm.9b01016
5. [5]
  X. Filella, L. Foj, Int. J. Mol. Sci. 17 (2016) 1784. doi: 10.3390/ijms17111784
6. [6]
  K. Rajalakshmi, T. Deng, S. Muthusamy, et al., Spectrochim. Acta Part A: Mol. Biomol. Spectrosc. 268 (2022) 120622. doi: 10.1016/j.saa.2021.120622
7. [7]
  J. Zhao, X. Dong, X. Hu, et al., Sci. Rep. 6 (2016) 22386. doi: 10.1038/srep22386
8. [8]
  M.A. Schroeder, H.J. Atherton, D.R. Ball, et al., FASEB J. 23 (2009) 2529–2538. doi: 10.1096/fj.09-129171
9. [9]
  F. Ling, X. Tang, H. Zhang, et al., Biotechnol. Lett. 43 (2021) 1455–1466. doi: 10.1007/s10529-021-03133-x
10. [10]
  A.U. Igamberdiev, Mitochondrion 52 (2020) 218–230. doi: 10.1016/j.mito.2020.04.003
11. [11]
  D. Granchi, N. Baldini, F.M. Ulivieri, R. Caudarella, Nutrients 11 (2019) 2576. doi: 10.3390/nu11112576
12. [12]
  V. Iacobazzi, V. Infantino, Biol. Chem. 395 (2014) 387–399. doi: 10.1515/hsz-2013-0271
13. [13]
  Z. Köstereli, K. Severin, Org. Biomol. Chem. 13 (2015) 252–257. doi: 10.1039/C4OB02095B
14. [14]
  Z. Zhu, J. Zhou, Z. Li, et al., Sens. Actuator. B: Chem. 208 (2015) 151–158. doi: 10.1016/j.snb.2014.11.001
15. [15]
  C. Liu, Y. Hang, T. Jiang, et al., Talanta 178 (2018) 847–853. doi: 10.1016/j.talanta.2017.10.026
16. [16]
  C. Zhang, L. Han, Q. Liu, et al., Spectrochim. Acta Part A: Mol. Biomol. Spectrosc. 253 (2021) 119561. doi: 10.1016/j.saa.2021.119561
17. [17]
  X. Chen, Z. Chen, Y. Hu, et al., Tetrahedron Lett. 100 (2022) 153870. doi: 10.1016/j.tetlet.2022.153870
18. [18]
  X.B. Xu, Y.Y. He, et al., Dye. Pigment. 201 (2022) 110194. doi: 10.1016/j.dyepig.2022.110194
19. [19]
  Y. Feng, S. Chi, G. Gao, et al., Sens. Actuator. B: Chem. 282 (2019) 16–26. doi: 10.1016/j.snb.2018.11.044
20. [20]
  X. Wang, T. Li, C. Ma, J. Hazard. Mater. 413 (2021) 125384. doi: 10.1016/j.jhazmat.2021.125384
21. [21]
  D.H. Ahn, J.W. Song, J. Comput. Chem. 42 (2021) 505–515. doi: 10.1002/jcc.26473
22. [22]
  S. Jo, M. Ahn, K. Bhattarai, et al., Chem. Phys. Lett. 761 (2020) 138023. doi: 10.1016/j.cplett.2020.138023
23. [23]
  S. Refaely-Abramson, S. Sharifzadeh, M. Jain, et al., Phys. Rev. B 88 (2013) 81204. doi: 10.1103/PhysRevB.88.081204
1. [1]
  Yiran Tao , Chunlei Dai , Zhaoxiang Xie , Xinru You , Kaiwen Li , Jun Wu , Hai Huang . Redox responsive polymeric nanoparticles enhance the efficacy of cyclin dependent kinase 7 inhibitor for enhanced treatment of prostate cancer. Chinese Chemical Letters, 2024, 35(8): 109170-. doi: 10.1016/j.cclet.2023.109170
2. [2]
  Panpan Wang , Hongbao Fang , Mengmeng Wang , Guandong Zhang , Na Xu , Yan Su , Hongke Liu , Zhi Su . A mitochondria targeting Ir(III) complex triggers ferroptosis and autophagy for cancer therapy: A case of aggregation enhanced PDT strategy for metal complexes. Chinese Chemical Letters, 2025, 36(1): 110099-. doi: 10.1016/j.cclet.2024.110099
3. [3]
  Ze Wang , Hao Liang , Annan Liu , Xingchen Li , Lin Guan , Lei Li , Liang He , Andrew K. Whittaker , Bai Yang , Quan Lin . Strength through unity: Alkaline phosphatase-responsive AIEgen nanoprobe for aggregation-enhanced multi-mode imaging and photothermal therapy of metastatic prostate cancer. Chinese Chemical Letters, 2025, 36(2): 109765-. doi: 10.1016/j.cclet.2024.109765
4. [4]
  Zhiyu Yu , Xiang Luo , Cheng Zhang , Xin Lu , Xiaohui Li , Pan Liao , Zhongqiu Liu , Rong Zhang , Shengtao Wang , Zhiqiang Yu , Guochao Liao . Mitochondria-targeted carrier-free nanoparticles based on dihydroartemisinin against hepatocellular carcinoma. Chinese Chemical Letters, 2024, 35(10): 109519-. doi: 10.1016/j.cclet.2024.109519
5. [5]
  Ling-Ling Wu , Xiangchuan Meng , Qingyang Zhang , Xiaowan Han , Feiya Yang , Qinghua Wang , Hai-Yu Hu , Nianzeng Xing . Heavy-atom engineered hypoxia-responsive probes for precisive photoacoustic imaging and cancer therapy. Chinese Chemical Letters, 2024, 35(4): 108663-. doi: 10.1016/j.cclet.2023.108663
6. [6]
  Fengkai Zou , Borui Su , Han Leng , Nini Xin , Shichao Jiang , Dan Wei , Mei Yang , Youhua Wang , Hongsong Fan . Red-emissive carbon quantum dots minimize phototoxicity for rapid and long-term lipid droplet monitoring. Chinese Chemical Letters, 2024, 35(10): 109523-. doi: 10.1016/j.cclet.2024.109523
7. [7]
  Ruofan Qi , Jing Zhang , Wang Sun , Bai Yu , Zhenhua Wang , Kening Sun . Solid-acid-Lewis-base interaction accelerates lithium ion transport for uniform lithium deposition. Chinese Chemical Letters, 2025, 36(6): 110009-. doi: 10.1016/j.cclet.2024.110009
8. [8]
  Jialin Guo , Mingrui Gu , Yahui Chen , Tao Xiong , Yiyang Zhang , Simin Chen , Mingle Li , Xiaoqiang Chen , Xiaojun Peng . Nucleic acid delivery by lipid nanoparticles for organ targeting. Chinese Chemical Letters, 2025, 36(11): 110849-. doi: 10.1016/j.cclet.2025.110849
9. [9]
  Qiang Li , Jiangbo Fan , Hongkai Mu , Lin Chen , Yongzhen Yang , Shiping Yu . Nucleus-targeting orange-emissive carbon dots delivery adriamycin for enhanced anti-liver cancer therapy. Chinese Chemical Letters, 2024, 35(6): 108947-. doi: 10.1016/j.cclet.2023.108947
10. [10]
  Xinran Xi , Xiyu Wang , Ziyue Xi , Chuanyong Fan , Yingying Jiang , Zhenhua Li , Lu Xu . Facile GSH responsive glycyrrhetinic acid conjunction for liver targeting therapy. Chinese Chemical Letters, 2025, 36(10): 110773-. doi: 10.1016/j.cclet.2024.110773
11. [11]
  Weijian Zhang , Xianyu Deng , Liying Wang , Jian Wang , Xiuting Guo , Lianggui Huang , Xinyi Wang , Jun Wu , Linjia Jiang . Poly(ferulic acid) nanocarrier enhances chemotherapy sensitivity of acute myeloid leukemia by selectively targeting inflammatory macrophages. Chinese Chemical Letters, 2024, 35(9): 109422-. doi: 10.1016/j.cclet.2023.109422
12. [12]
  Kai Wang , Yun Wang , Lihang Wang , Zhuhai Li , Xi Yu , Xuanhe You , Diwei Wu , Yueming Song , Jiancheng Zeng , Zongke Zhou , Shishu Huang , Yunfeng Lin . Therapeutic siRNA targeting CC chemokine receptor 2 loaded with tetrahedral framework nucleic acid alleviates neuropathic pain by regulating microglial polarization. Chinese Chemical Letters, 2025, 36(3): 109868-. doi: 10.1016/j.cclet.2024.109868
13. [13]
  Qi Wei , Hua Xin , Xiaolong Wang , Changjuan Qin , Yuanzhen Su , Di Li , Jianxun Ding . Unimolecular chiral poly(amino acid)s as adjuvants of nanovaccines for augmented cancer immunotherapy. Chinese Chemical Letters, 2025, 36(11): 111477-. doi: 10.1016/j.cclet.2025.111477
14. [14]
  Jiajun Lu , Zhehui Liao , Tongxiang Cao , Shifa Zhu . Synergistic Brønsted/Lewis acid catalyzed atroposelective synthesis of aryl-β-naphthol. Chinese Chemical Letters, 2025, 36(1): 109842-. doi: 10.1016/j.cclet.2024.109842
15. [15]
  Chao Liu , Liming Gong , Yanhong Liu , Shuangqing Wang , Hao Wu , Liqing Chen , Mingji Jin , Zhonggao Gao , Wei Huang . Lipoic acid-locked reduction-responsive core-cross-linked micelles delivering paclitaxel for triple-negative breast cancer treatment. Chinese Chemical Letters, 2025, 36(8): 110570-. doi: 10.1016/j.cclet.2024.110570
16. [16]
  Fan Zheng , Runsha Xiao , Shuai Huang , Zhikang Chen , Chen Lai , Anyao Bi , Heying Yao , Xueping Feng , Zihua Chen , Wenbin Zeng . Accurate visualization colorectal cancer by monitoring viscosity variations with a novel mitochondria-targeted fluorescent probe. Chinese Chemical Letters, 2025, 36(2): 109876-. doi: 10.1016/j.cclet.2024.109876
17. [17]
  Meiling Xu , Xinyang Li , Pengyuan Liu , Junjun Liu , Xiao Han , Guodong Chai , Shuangling Zhong , Bai Yang , Liying Cui . A novel and visible ratiometric fluorescence determination of carbaryl based on red emissive carbon dots by a solvent-free method. Chinese Chemical Letters, 2025, 36(2): 109860-. doi: 10.1016/j.cclet.2024.109860
18. [18]
  Runze Liu , Yankai Bian , Weili Dai . Qualitative and quantitative analysis of Brønsted and Lewis acid sites in zeolites: A combined probe-assisted 1H MAS NMR and NH3-TPD investigation. Chinese Journal of Structural Chemistry, 2024, 43(4): 100250-100250. doi: 10.1016/j.cjsc.2024.100250
19. [19]
  Yanfei Liu , Yaqin Hu , Yifu Tan , Qiwen Chen , Zhenbao Liu . Tumor acidic microenvironment activatable DNA nanostructure for precise cancer cell targeting and inhibition. Chinese Chemical Letters, 2025, 36(1): 110289-. doi: 10.1016/j.cclet.2024.110289
20. [20]
  Zhaoyong Kang , Shen Li , Yan Li , Jingfeng Song , Yangrui Peng , Yihua Chen . Small molecular inhibitors and degraders targeting STAT3 for cancer therapy: An updated review (from 2022 to 2024). Chinese Chemical Letters, 2025, 36(7): 110447-. doi: 10.1016/j.cclet.2024.110447

Get Citation

PDF

XML

Metrics

PDF Downloads(1)
Abstract views(1019)
HTML views(48)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142