Citation: Peide Zhu, Yangjia Liu, Yaoyao Tang, Siqi Zhu, Xinyang Liu, Lei Yin, Quan Liu, Zhiqiang Yu, Quan Xu, Dixian Luo, Juncheng Wang. Bi-doped carbon quantum dots functionalized liposomes with fluorescence visualization imaging for tumor diagnosis and treatment[J]. Chinese Chemical Letters, ;2024, 35(4): 108689. doi: 10.1016/j.cclet.2023.108689 shu

Bi-doped carbon quantum dots functionalized liposomes with fluorescence visualization imaging for tumor diagnosis and treatment

Peide Zhu ^{a, 1} ,
Yangjia Liu ^{b, 1} ,
Yaoyao Tang ^{a, 1} ,
Siqi Zhu ^c ,
Xinyang Liu ^a ,
Lei Yin ^c ,
Quan Liu ^c ,
Zhiqiang Yu ^b ,
Quan Xu ^{a, *,} ,
Dixian Luo ^{c, *,} ,
Juncheng Wang ^{d, *,}

a.
State Key Laboratory of Heavy Oil Processing, China University of Petroleum-Beijing, Beijing 102249, China
b.
Department of Laboratory Medicine, Dongguan Institute of Clinical Cancer Research, Affiliated Dongguan Hospital, Southern Medical University, Dongguan 523058, China
c.
Department of Laboratory Medicine, Huazhong University of Science and Technology Union Shenzhen Hospital (Nanshan Hospital), Shenzhen 518052, China
d.
Institute of Stomatology, First Medical Center, Chinese PLA General Hospital, Beijing 100853, China

xuquan@cup.edu.cn

luodixian_2@163.com

wbhwjc527@126.com

Received Date: 10 April 2023
Revised Date: 9 June 2023
Accepted Date: 12 June 2023
Available Online: 15 June 2023

Figures(5)

Liposomes are one of the significant classes of antitumor nanomaterials and the most successful nanomedicine drugs in clinical translation. However, it is difficult to accurately reveal liposome delivery modes and drug release rates at different pH values to assess the biodistribution and drug delivery pathways in vivo. Here, we established a strategy to integrate Bi-doped carbon quantum dots (CQDs) with liposomes to produce fluorescence visualization and therapeutic effects, namely lipo/Bi-doped CQDs. Lipo/Bi-doped CQDs show good water solubility and physicochemical properties, which can be used for in vitro labeling of colon cancer (CT26) cells and in vivo imaging localization tracking tumors for monitoring. Simultaneously, thanks to the excellent pH sensitivity and ion doping characteristic of Bi-doped CQDs, lipo/Bi-doped CQDs can be used to reveal the drug release rate of liposomes at different pH values and exhibit potential effects in vivo antitumor therapy.
- Bi-doped CQDs,
- Lipo/Bi-doped CQDs,
- pH sensitivity,
- In vitro/in vivo imaging,
- Diagnosis and treatment integration
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