Citation: Yuqin Wu, Tian Xia, Xiaohui Ma, Lei Lei, Lulu Du, Xiaoning Xu, Xiangyi Liu, Yueting Shi, Xingyi Li, Deqing Lin. Autocatalytic strategy for tuning drug release from peptide-drug supramolecular hydrogel[J]. Chinese Chemical Letters, ;2023, 34(10): 108209. doi: 10.1016/j.cclet.2023.108209 shu

Autocatalytic strategy for tuning drug release from peptide-drug supramolecular hydrogel

Institute of Biomedical Engineering, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou 325027, China

lixingyi_1984@mail.eye.ac.cn

dq.lin@wmu.edu.cn

Received Date: 14 November 2022
Revised Date: 3 February 2023
Accepted Date: 8 February 2023
Available Online: 11 February 2023

Figures(5)

Peptide-drug conjugates (PDCs) composed of peptide, spacer and drug have gained extensive attention in the field of drug delivery owing to its precise control over the drug payload and architecture. However, the achievement of controllable and rapid drug release at targeted site by PDCs is still a great challenge for pharmaceutist. Herein, we introduced the histidine residue into PDCs to generate a supramolecular hydrogel via a pH-trigger strategy, which exhibited an autocatalytic effect to precisely tune drug release from PDCs hydrogel. Using indomethacin (Idm) as model drug, various PDCs (Y(Idm)EEH, Y(Idm)EEK and Y(Idm)EER) were synthesized and their self-assembling properties were investigated in terms of critical aggregation concentration (CAC), transmission electron microscopy (TEM) and rheometer. Introduction of histidine residue into PDCs presented a robust catalytic activity on the ester hydrolysis of p-nitrophenyl acetate in aqueous solution, as well conferred the autocatalytic capacity to hydrolyze the PDCs into active parent drug (Idm). Overall, we reported an autocatalytic activity of histidine residue to precisely tune drug release from PDCs hydrogels.
- Peptide-drug conjugates,
- Supramolecular hydrogel,
- Autocatalysis,
- Hydrolysis,
- Drug release
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