Citation: Han-Yu Lu, Zhi-Tao He. Catalytic asymmetric synthesis of 1,4-enynes[J]. Chinese Chemical Letters, ;2023, 34(8): 108105. doi: 10.1016/j.cclet.2022.108105 shu

Catalytic asymmetric synthesis of 1,4-enynes

Han-Yu Lu ^{a, b} ,
Zhi-Tao He ^{a, c, *,}

a.
CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Shanghai 200032, China
b.
School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China
c.
School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China

^☆

^th

hezt@sioc.ac.cn

Received Date: 21 October 2022
Revised Date: 20 December 2022
Accepted Date: 25 December 2022
Available Online: 27 December 2022

Figures(28)

1,4-Enyne units are ubiquitous skeletons in biologically active molecules and natural products. Especially, they represent versatile building blocks for abundant downstream derivatizations via controllable modifications of both alkene and alkyne units independently. Recently, great efforts have been made to establish efficient protocols to achieve optically active 1,4-enynes. Considering the enormous application potential of enantioenriched 1,4-enyne units but no related review on this topic has been described, here we aim to provide a comprehensive summary on the catalytic methods established for enantioselective constructions of these intriguing skeletons. According to the reaction types, this review is divided into five parts, including asymmetric allylic substitution, asymmetric propargylic substitution, asymmetric alkynylallylic substitution, asymmetric hydroalkynylation and asymmetric 1,2-addition of alkynes to conjugated imines or ketones.
- 1,4-Enynes,
- Catalytic reaction,
- Asymmetric synthesis
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