Citation: Shu-Min Wang, Hui Wang, Wei Zhao, Jing-Juan Xu, Hong-Yuan Chen. Single-particle detection of cholesterol based on the host-guest recognition induced plasmon resonance energy transfer[J]. Chinese Chemical Letters, ;2023, 34(7): 108053. doi: 10.1016/j.cclet.2022.108053 shu

Single-particle detection of cholesterol based on the host-guest recognition induced plasmon resonance energy transfer

Shu-Min Wang ^a ,
Hui Wang ^a ,
Wei Zhao ^{a, b, *,} ,
Jing-Juan Xu ^{a, *,} ,
Hong-Yuan Chen ^a

a.
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China
b.
Institute of Nanochemistry and Nanobiology, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China

wei_zhao@shu.edu.cn

xujj@nju.edu.cn

Received Date: 30 June 2022
Revised Date: 15 November 2022
Accepted Date: 6 December 2022
Available Online: 9 December 2022

Figures(6)

Plasmon resonance energy transfer (PRET) occurs between the plasmonic nanoparticles (NPs) and organic dyes forming donor-acceptor pairs, which has great potential in quantitative analytical chemistry because of its excellent sensitivity under dark-field microscopy (DFM). Herein, we introduce supramolecular β-cyclodextrin (β-CD) to design a host-guest recognition plasmonic nano-structure modified gold nanoparticles (GNPs), while GNPs and rhodamine molecule (RB) act as the donor and acceptor, respectively. In the presence of the target cholesterol, due to the stronger binding of cholesterol with β-CD, RB molecules are released, inducing the inhibition of PRET, as well as the increase of the scattering intensity of GNPs. The proposed strategy achieves a linear range from 0.02 µmol/L to 2.0 µmol/L for cholesterol detection, and reaches a limit of detection (LOD) of 6.7 nmol/L. This host-guest recognition strategy can easily integrate receptor-donor pair into one nanoparticle, which simplifies the construction of the PRET platform, and further provides an effective approach for PRET-based analytical applications. Afterwards, the proposed PRET strategy was successfully applied for the detection of cholesterol in serum samples with high sensitivity and specificity. The proposed method provides an effective clinically potential means for the detection of cholesterol and other disease-related biomarkers.
- Dark field microscopy,
- Localized surface plasmon resonance,
- Plasmon resonance energy transfer,
- GNPs@CD nanoparticles,
- Cholesterol
1. [1]
  J. Li, T. Liu, S. Liu, et al., Biosens. Bioelectron. 120 (2018) 137–143. doi: 10.1016/j.bios.2018.08.046
2. [2]
  H.C. Chang, J.A. Ho, Anal. Chem. 87 (2015) 10362–10367. doi: 10.1021/acs.analchem.5b02452
3. [3]
  P.W.F. Wilson, R.B. D'Agostino, D. Levy, et al., Circulation 97 (1998) 1837–1847. doi: 10.1161/01.CIR.97.18.1837
4. [4]
  K. Simons, E. Ikonen, Science 290 (2000) 1721–1726. doi: 10.1126/science.290.5497.1721
5. [5]
  X. Jiang, Z. Tan, L. Lin, et al., Small Methods 2 (2018) 1800182. doi: 10.1002/smtd.201800182
6. [6]
  Q. Zhong, Z. Xie, H. Ding, et al., Small 11 (2015) 5766–5770. doi: 10.1002/smll.201501739
7. [7]
  Y. Huang, J. Tan, L. Cui, et al., Biosens. Bioelectron. 102 (2018) 560–567. doi: 10.1016/j.bios.2017.11.037
8. [8]
  A. Sinha, S. Basiruddin, A. Chakraborty, et al., ACS Appl. Mater. Interfaces 7 (2015) 1340–1347. doi: 10.1021/am507817b
9. [9]
  Q. Su, L. Gan, Y. Zhu, et al., Sens. Actuators B: Chem. 335 (2021) 129715. doi: 10.1016/j.snb.2021.129715
10. [10]
  F. Qi, Y. Han, Z. Ye, et al., Anal. Chem. 90 (2018) 11146–11153. doi: 10.1021/acs.analchem.8b03211
11. [11]
  J. Ma, L. Zhan, R.S. Li, et al., Anal. Chem. 89 (2017) 8484–8489. doi: 10.1021/acs.analchem.7b02033
12. [12]
  S. Wang, Z. Ye, X. Wang, et al., ACS Appl. Nano Mater. 2 (2019) 6646–6654. doi: 10.1021/acsanm.9b01517
13. [13]
  T. Li, X. Xu, G. Zhang, et al., Anal. Chem. 88 (2016) 4188–4191. doi: 10.1021/acs.analchem.6b00535
14. [14]
  Z. Chen, J. Li, X. Chen, et al., J. Am. Chem. Soc. 137 (2015) 1903–1908. doi: 10.1021/ja5112628
15. [15]
  B. Xiong, Z. Huang, H. Zou, et al., ACS Nano 11 (2017) 541–548. doi: 10.1021/acsnano.6b06591
16. [16]
  J. Ma, M.X. Gao, H. Zuo, et al., Anal. Chem. 92 (2020) 14278–14283. doi: 10.1021/acs.analchem.0c03991
17. [17]
  P.F. Gao, Y.F. Li, C.Z. Huang, TrAC Trends Anal. Chem. 124 (2020) 115805. doi: 10.1016/j.trac.2020.115805
18. [18]
  G.L. Liu, Y.T. Long, Y. Choi, et al., Nat. Methods 4 (2007) 1015–1017. doi: 10.1038/nmeth1133
19. [19]
  Y. Cao, T. Xie, R.C. Qian, et al., Small 13 (2017) 1601955. doi: 10.1002/smll.201601955
20. [20]
  X. Yan, C. Xia, B. Chen, et al., Anal. Chem. 92 (2020) 2130–2135. doi: 10.1021/acs.analchem.9b04685
21. [21]
  M.X. Gao, H.Y. Zou, Y.F. Li, et al., Anal. Chem. 89 (2017) 1808–1814. doi: 10.1021/acs.analchem.6b04124
22. [22]
  D. Wu, Y. Kong, Anal. Chem. 91 (2019) 5961–5967. doi: 10.1021/acs.analchem.9b00378
23. [23]
  Y. Wu, Z. Han, L. Wei, et al., Anal. Chem. 92 (2020) 5464–5472. doi: 10.1021/acs.analchem.0c00208
24. [24]
  D.M. Alzate-Sánchez, B.J. Smith, A. Alsbaiee, et al., Chem. Mater. 28 (2016) 8340–8346. doi: 10.1021/acs.chemmater.6b03624
25. [25]
  Y. Zhao, Y. Huang, H. Zhu, et al., J. Am. Chem. Soc. 138 (2016) 16645–16654. doi: 10.1021/jacs.6b07590
26. [26]
  D.N. Heo, W.K. Ko, H.J. Moon, et al., ACS Nano 8 (2014) 12049–12062. doi: 10.1021/nn504329u
27. [27]
  M. Koo, K.T. Oh, G. Noh, et al., ACS Appl. Mater. Interfaces 10 (2018) 24450–24458. doi: 10.1021/acsami.8b08595
28. [28]
  Q. Ma, X. Fang, J. Zhang, et al., J. Mater. Chem. B 8 (2020) 4039–4045. doi: 10.1039/D0TB00462F
29. [29]
  Y. Wang, Y. Han, X. Tan, et al., J. Mater. Chem. B 9 (2021) 2584–2593. doi: 10.1039/D0TB02857F
30. [30]
  L. Xiao, L. Wei, X. Cheng, et al., Anal. Chem. 83 (2011) 7340–7347. doi: 10.1021/ac2012366
31. [31]
  H. Wang, C.H. Xu, W. Zhao, et al., Anal. Chem. 93 (2021) 10727–10734. doi: 10.1021/acs.analchem.1c02761
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