Citation: Yefei Jiang, Zhiyong Zeng, Jianhua Yao, Ying Guan, Peipei Jia, Xiaoli Zhao, Lin Xu. Treatment of Alzheimer's disease with small-molecule photosensitizers[J]. Chinese Chemical Letters, ;2023, 34(5): 107966. doi: 10.1016/j.cclet.2022.107966 shu

Treatment of Alzheimer's disease with small-molecule photosensitizers

Yefei Jiang ^a ,
Zhiyong Zeng ^a ,
Jianhua Yao ^{b, *,} ,
Ying Guan ^{b, *,} ,
Peipei Jia ^{a, c} ,
Xiaoli Zhao ^a ,
Lin Xu ^{a, c, **,}

a.
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China
b.
Joint Institute of Tobacco and Health, Yunnan Academy of Tobacco Science, Kunming 650024, China
c.
Wuhu Hospital Affiliated to East China Normal University (The Second People's Hospital of Wuhu), Wuhu 241001, China

^**

jhyao_2007@126.com

125176198@qq.com

lxu@chem.ecnu.edu.cn

Received Date: 5 July 2022
Revised Date: 20 October 2022
Accepted Date: 24 October 2022
Available Online: 1 November 2022

Figures(15)

Alzheimer's disease is a neurodegenerative disease that signals for excess β-amyloid (Aβ) aggregation. Although people have made great attempts to control the aggregation of Aβ, no effective medications have been produced yet. Due to its excellent temporal and spatial selectivity, photodynamic treatment has been gradually employed and interfered in the aggregation process of Aβ, with some achievement. To enhance the research and application of photodynamic therapy in Alzheimer's disease, this paper reviews the progress of small-molecule photosensitizers in the treatment of Alzheimer's disease in recent years and outlines existing tactics and potential obstacles.
- Alzheimer's disease,
- Photosensitizer,
- A aggregation,
- PDT
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