Citation: Yumeng Song, Xiuli Tao, Wenbin Liang, Xia Zhong, Ruo Yuan, Ying Zhuo. Advanced Pt hollow nanospheres/rubrene nanoleaves coupled with M-shaped DNA walker for ultrasensitive electrochemiluminescence bioassay[J]. Chinese Chemical Letters, ;2023, 34(6): 107957. doi: 10.1016/j.cclet.2022.107957 shu

Advanced Pt hollow nanospheres/rubrene nanoleaves coupled with M-shaped DNA walker for ultrasensitive electrochemiluminescence bioassay

Key Laboratory of Luminescence Analysis and Molecular Sensing, Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China

zhonglyx@swu.edu.cn

yingzhuo@swu.edu.cn

Received Date: 6 July 2022
Revised Date: 30 September 2022
Accepted Date: 25 October 2022
Available Online: 28 October 2022

Figures(5)

Herein, an intense electrochemiluminescence (ECL) was achieved based on Pt hollow nanospheres/rubrene nanoleaves (Pt HNSs/Rub NLs) without the addition of any coreactant, which was employed for ultrasensitive detection of carcinoembryonic antigen (CEA) coupled with an M-shaped DNA walker (M-DNA walker) as signal switch. Specifically, in comparison with platinum nanoparticles (Pt NPs), Pt HNSs revealed excellent catalytic performance and pore confinement-enhanced ECL, which could significantly amplify ECL intensity of Rub NLs/dissolved O₂ (DO) binary system. Then, the tracks and M-DNA walker were confined on the Pt HNSs simultaneously to promote the reaction efficiency, whose M-structure boosted the interaction sites between walking strands and tracks and reduced the rigidity of their recognition. Once the CEA approached the sensing interface, the M-DNA walker was activated based on highly specific aptamer recognition to recover ECL intensity with the assistance of exonuclease Ⅲ (Exo Ⅲ). As proof of concept, the "on-off-on" switch aptasensor was constructed for CEA detection with a low detection limit of 0.20 fg/mL. The principle of the constructed ECL aptasensor also enables a universal platform for sensitive detection of other tumor markers.
- Platinum hollow nanospheres,
- Electrochemiluminescence aptasensor,
- M-shaped DNA walker,
- On-off-on switch,
- Carcinoembryonic antigen
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沈阳化工大学材料科学与工程学院沈阳 110142