Citation: Jiayi Sun, Jingyang Li, Xi Li, Lu Yang, Yitong Liu, Huile Gao, Li Xiang. Sequentially responsive size reduction and drug release of core-satellite nanoparticles to enhance tumor penetration and effective tumor suppression[J]. Chinese Chemical Letters, ;2023, 34(5): 107891. doi: 10.1016/j.cclet.2022.107891 shu

Sequentially responsive size reduction and drug release of core-satellite nanoparticles to enhance tumor penetration and effective tumor suppression

Jiayi Sun ^a ,
Jingyang Li ^a ,
Xi Li ^b ,
Lu Yang ^a ,
Yitong Liu ^{c, *,} ,
Huile Gao ^d ,
Li Xiang ^{a, *,}

a.
State Key Laboratory of Southwestern Chinese Medicine Resources, Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
b.
Public Health Clinical Center of Chengdu, Chengdu 610061, China
c.
The Third Affiliated Hospital of Chengdu University of TCM/Chengdu Pidu District Hospital of Traditional Chinese Medicine, Chengdu 611730, China
d.
West China School of Pharmacy, Sichuan University, Chengdu 610041, China

Liuxsc1989@126.com

xianglydr@cdutcm.edu.cn

Received Date: 6 August 2022
Revised Date: 6 October 2022
Accepted Date: 7 October 2022
Available Online: 13 October 2022

Figures(4)

Poor tumor accumulation remains a serious challenge for nanomedicines to achieve ideal antitumor outcomes. The different size preferences for systematic circulation, tumor retention and deep permeation have attracted great attention when designing antineoplastic nano-delivery system. Herein, we developed a nano-system which can shrink its size in tumor microenvironment to achieve better tumor retention and penetration. In this work, the cationic bovine serum albumin-protected, doxorubicin-loaded gold nanoclusters (CAuNC-DOX) and amino-functionalized mesoporous silica nanoparticles (MSN) are connected by Fe²⁺ and are further coated with hyaluronic acid (HA) to obtain a core-satellite MSN-Fe-CAuNC-DOX@HA nano system (MFADH). When reaching the tumor site, the HA shell, which endows the system with both good biocompatibility and preferable tumor targeting ability, was disintegrated, followed by acid-stimulated release of small-sized pharmacological unit—CAuNC-DOX for further tumor penetration. As demonstrated in both in vitro and in vivo results, MFADH showed excellent antitumor effect, providing a proof of concept for the feasibility of shrinkable nanoplatforms in tumor treatment.
- Size reducible,
- Tumor penetration,
- Core-satellite structure,
- Mesoporous silica nanoparticles,
- Gold nanoclusters,
- Experimental techniques
1. [1]
  F.M. Kievit, M. Zhang, Adv. Mater. 23 (2011) H217-H247. doi: 10.1002/adma.201102313
2. [2]
  Y. Zhou, X. Chen, J. Cao, H. Gao, J. Mater. Chem. B 8 (2020) 6765-6781. doi: 10.1039/d0tb00649a
3. [3]
  S. Yang, H. Gao, Pharmacol. Res. 126 (2017) 97-108. doi: 10.1016/j.phrs.2017.05.004
4. [4]
  X. Gao, J. Zhang, Z. Huang, ACS Appl. Mater. Interfaces 9 (2017) 29457-29468. doi: 10.1021/acsami.7b05119
5. [5]
  A. Schädlich, H. Caysa, T. Mueller, et al., ACS Nano 5 (2011) 8710-8720. doi: 10.1021/nn2026353
6. [6]
  M.I. Setyawati, C.Y. Tay, B.H. Bay, D.T. Leong, ACS Nano 11 (2017) 5020-5030. doi: 10.1021/acsnano.7b01744
7. [7]
  Y. Niu, J. Zhu, Y. Li, et al., J. Control. Release 277 (2018) 35-47. doi: 10.1016/j.jconrel.2018.03.012
8. [8]
  B. Su, R. Wang, Z. Xie, et al., Small 14 (2018) 1702331. doi: 10.1002/smll.201702331
9. [9]
  J. Wang, W. Mao, L.L. Lock, et al., ACS Nano 9 (2015) 7195-7206. doi: 10.1021/acsnano.5b02017
10. [10]
  J. Hu, X. Yuan, F. Wang, et al., Chin. Chem. Lett. 32 (2021) 1341-1347. doi: 10.1016/j.cclet.2020.11.006
11. [11]
  W. Yu, M. Shevtsov, X. Chen, H. Gao, Chin. Chem. Lett. 31 (2020) 1366-1374. doi: 10.1016/j.cclet.2020.02.036
12. [12]
  C. Hu, X. Yang, R. Liu, et al., ACS Appl. Mater. Interfaces 10 (2018) 22571-22579. doi: 10.1021/acsami.8b04847
13. [13]
  X. Cun, M. Li, S. Wang, et al., Nanoscale 10 (2018) 9935-9948. doi: 10.1039/c8nr00640g
14. [14]
  W. Yu, R. Liu, Y. Zhou, H. Gao, ACS Cent. Sci. 6 (2020) 100-116. doi: 10.1021/acscentsci.9b01139
15. [15]
  Z. Shi, Q. Li, L. Mei, Chin. Chem. Lett. 31 (2020) 1345-1356. doi: 10.1016/j.cclet.2020.03.001
16. [16]
  C. Hu, X. Cun, S. Ruan, et al., Biomaterials 168 (2018) 64-75. doi: 10.1016/j.biomaterials.2018.03.046
17. [17]
  H. Li, J. Du, J. Liu, et al., ACS Nano 10 (2016) 6753-6761. doi: 10.1021/acsnano.6b02326
18. [18]
  R. Tong, H.H. Chiang, D.S. Kohane, Proc. Natl. Acad. Sci. U. S. A. 110 (2013) 19048-19053. doi: 10.1073/pnas.1315336110
19. [19]
  J. Wang, S. Shen, J. Li, Z. Cao, X. Yang, ACS Nano 15 (2021) 4636-4646. doi: 10.1021/acsnano.0c08996
20. [20]
  W. Wu, Y. Pu, J. Shi, Adv. Sci. 8 (2021) 2002816. doi: 10.1002/advs.202002816
21. [21]
  Z. Wang, Y. Wang, X. Sun, et al., Small 18 (2022) 2200588. doi: 10.1002/smll.202200588
22. [22]
  R. Liu, W. Jia, Y. Wang, et al., Research 2022 (2022) 9847612.
23. [23]
  R. Liu, C. Hu, Y. Yang, J. Zhang, H. Gao, Acta Pharm. Sin. B 9 (2019) 410-420. doi: 10.1016/j.apsb.2018.09.001
24. [24]
  Y. Zhou, G. Quan, Q. Wu, et al., Acta Pharm. Sin. B 8 (2018) 165-177. doi: 10.1016/j.apsb.2018.01.007
25. [25]
  A. García-Fernández, F. Sancenón, R. Martínez-Máñez, Adv. Drug Deliv. Rev. 177 (2021) 113953. doi: 10.1016/j.addr.2021.113953
26. [26]
  Q. Lei, W. Qiu, J. Hu, et al., Small 12 (2016) 4286-4298. doi: 10.1002/smll.201601137
27. [27]
  Z. Luo, K. Cai, Y. Hu, et al., Angew. Chem. Int. Ed. 50 (2011) 640-643. doi: 10.1002/anie.201005061
28. [28]
  J. Hu, D. Xiao, X. Zhang, Small 12 (2016) 3344-3359. doi: 10.1002/smll.201600325
29. [29]
  R. Jin, Z. Liu, Y. Bai, et al., Adv. Funct. Mater. 28 (2018) 1801961. doi: 10.1002/adfm.201801961
30. [30]
  Z. Luo, Y. Dai, H. Gao, Acta Pharm. Sin. B 9 (2019) 1099-1112. doi: 10.1016/j.apsb.2019.06.004
31. [31]
  F. Tang, L. Li, D. Chen, Adv. Mater. 24 (2012) 1504-1534. doi: 10.1002/adma.201104763
1. [1]
  Song Tingting , Zhao Hongyu , Hu Yu , Sun Nannan , Zhang Haijiao . Facile assembly of mesoporous silica nanoparticles with hierarchical pore structure for CO₂ capture. Chinese Chemical Letters, 2019, 30(12): 2347-2350. doi: 10.1016/j.cclet.2019.07.024
2. [2]
  Quan Zhang , Zhou Ye , Shu-Ting Wang , Jian Yin . Facile one-pot synthesis of PEGylated monodisperse mesoporous silica nanoparticles with controllable particle sizes. Chinese Chemical Letters, 2014, 25(2): 257-260.
3. [3]
  Yu-Jie Chang , Xi-Zhen Liu , Qing Zhao , Xiao-Hai Yang , Ke-Min Wang , Qing Wang , Min Lin , Meng Yang . P(VPBA-DMAEA) as a pH-sensitive nanovalve for mesoporous silica nanoparticles based controlled release. Chinese Chemical Letters, 2015, 26(10): 1203-1208. doi: 10.1016/j.cclet.2015.08.005
4. [4]
  Zhang Wei , Kan Qiming , Chen Lu , Xie Luyao , Cui Mingshu , Xi Ziyue , Xi Yanru , Li Sanming , Xu Lu . Preparation and application of mesoporous core-shell nanosilica using leucine derivative as template in effective drug delivery. Chinese Chemical Letters, 2020, 31(5): 1165-1167. doi: 10.1016/j.cclet.2019.05.059
5. [5]
  Jiang Hu , Xinwei Yuan , Fei Wang , Huile Gao , Xilin Liu , Wei Zhang . The progress and perspective of strategies to improve tumor penetration of nanomedicines. Chinese Chemical Letters, 2021, 32(4): 1341-1347. doi: 10.1016/j.cclet.2020.11.006
6. [6]
  Gao Wenxia , Hu Yalong , Xu Long , Liu Miaochang , Wu Huayue , He Bin . Dual pH and glucose sensitive gel gated mesoporous silica nanoparticles for drug delivery. Chinese Chemical Letters, 2018, 29(12): 1795-1798. doi: 10.1016/j.cclet.2018.05.022
7. [7]
  Jie Xu , Juanmin Li , Wencheng Zhong , Mengyao Wen , Gleb Sukhorukov , Li Shang . The density of surface ligands regulates the luminescence of thiolated gold nanoclusters and their metal ion response. Chinese Chemical Letters, 2021, 32(8): 2390-2394. doi: 10.1016/j.cclet.2021.02.037
8. [8]
  Wenying Mi , Shuang Tang , Shaoshi Guo , Hejing Li , Na Shao . In situ synthesis of red fluorescent gold nanoclusters with enzyme-like activity for oxidative stress amplification in chemodynamic therapy. Chinese Chemical Letters, 2022, 33(3): 1331-1336. doi: 10.1016/j.cclet.2021.07.073
9. [9]
  Bai Zhiqun , Ren Xiangling , Gong Zhen , Hao Chenxi , Chen Yongmei , Wan Pingyu , Meng Xianwei . 11-Mercaptoundecanoic acid functionalized gold nanoclusters as fluorescent probes for the sensitive detection of Cu²⁺ and Fe³⁺ ions. Chinese Chemical Letters, 2017, 28(9): 1901-1904. doi: 10.1016/j.cclet.2017.05.005
10. [10]
  Tianlu Zhang , Zhiguo Lu , Jianze Wang , Jie Shen , Qiulian Hao , Yan Li , Jun Yang , Yunwei Niu , Zuobing Xiao , Lei Chen , Xin Zhang . Preparation of mesoporous silica nanoparticle with tunable pore diameters for encapsulating and slowly releasing eugenol. Chinese Chemical Letters, 2021, 32(5): 1755-1758. doi: 10.1016/j.cclet.2020.12.033
11. [11]
  Wu Zili , Mullins David R. , Allard Lawrence F. , Zhang Qianfan , Wang Laisheng . CO oxidation over ceria supported Au₂₂ nanoclusters: Shape effect of the support. Chinese Chemical Letters, 2018, 29(6): 795-799. doi: 10.1016/j.cclet.2018.01.038
12. [12]
  Cui Hao-Dong , Hu De-Hong , Zhang Jing-Nan , Gao Guan-Hui , Zheng Cui-Fang , Gong Ping , Xi Xing-Hua , Sheng Zong-Hai , Cai Lin-Tao . Theranostic gold cluster nanoassembly for simultaneous enhanced cancer imaging and photodynamic therapy. Chinese Chemical Letters, 2017, 28(7): 1391-1398. doi: 10.1016/j.cclet.2016.12.038
13. [13]
  Xiaomeng Zhou , Xinjie Wang , Li Shang . Ratiometric fluorescence and visual sensing of ATP based on gold nanocluster-encapsulated metal-organic framework with a smartphone. Chinese Chemical Letters, 2023, 34(8): 108093-1-108093-4. doi: 10.1016/j.cclet.2022.108093
14. [14]
  Li Wentao , Sun Xiaomei , Zhao Xuan , Wang Wei , Xu Shenghao , Luo Xiliang . Rapid pattern recognition of different types of sulphur-containing species as well as serum and bacteria discrimination using Au NCs-Cu²⁺ complexes. Chinese Chemical Letters, 2020, 31(9): 2473-2477. doi: 10.1016/j.cclet.2020.04.027
15. [15]
  Jiafeng Zou , Wenwen Fei , Yao Qiao , Ying Yang , Zongbing He , Lei Feng , Man-Bo Li , Zhikun Wu . Combined synthesis of interconvertible Au₁₁Cd and Au₂₆Cd₅ for photocatalytic oxidations involving singlet oxygen. Chinese Chemical Letters, 2023, 34(4): 107660-1-107660-4. doi: 10.1016/j.cclet.2022.07.003
16. [16]
  Zhang Zhiyong , Runa A. , Wu Jie , Zhang Han , Li Xia , He Zhiqiang . Bioresponsive nanogated ensemble based on structure-switchable aptamer directed assembly and disassembly of gold nanoparticles from mesoporous silica supports. Chinese Chemical Letters, 2019, 30(3): 779-782. doi: 10.1016/j.cclet.2018.10.019
17. [17]
  Li Ting , Sun Jiefang , Liu Jinyuan , Dong Baolei , Zhao Huachao , Qiao Xiaoting , Shan Wencong , Zhang Jing , Shao Bing . Constructing boronate-bridged core-satellite gold nanoassembly and its application in high sensitive colorimetric detection of benzoyl peroxide residues in food matrices. Chinese Chemical Letters, 2020, 31(2): 439-442. doi: 10.1016/j.cclet.2019.08.051
18. [18]
  Zhou Guoyong , Luo Yingchun , Li Heping . Progress in Polymer Nano Carriers for Improving Deep Tumor Penetration. Chemistry, 2017, 80(10): 891-899.
19. [19]
  Huaisong Wang , Lin Wang , Yueyuan Gao , Ya Ding . The effect of drug position on the properties of paclitaxel-conjugated gold nanoparticles for liver tumor treatment. Chinese Chemical Letters, 2021, 32(3): 1041-1045. doi: 10.1016/j.cclet.2020.08.044
20. [20]
  TIAN Bo-Wen , FENG Fei , ZHAO Bin , LUO Fan , YANG Xue-Lei , ZHOU Hai-Mei , LI Xin-Xin . Study of Monolithic Integrated Micro Gas Chromatography Chip. Chinese Journal of Analytical Chemistry, 2018, 46(9): 1363-1371. doi: 10.11895/j.issn.0253-3820.181027

Get Citation

PDF

XML

Metrics

PDF Downloads(2)
Abstract views(108)
HTML views(7)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142