Citation: Jiayi Sun, Jingyang Li, Xi Li, Lu Yang, Yitong Liu, Huile Gao, Li Xiang. Sequentially responsive size reduction and drug release of core-satellite nanoparticles to enhance tumor penetration and effective tumor suppression[J]. Chinese Chemical Letters, ;2023, 34(5): 107891. doi: 10.1016/j.cclet.2022.107891 shu

Sequentially responsive size reduction and drug release of core-satellite nanoparticles to enhance tumor penetration and effective tumor suppression

Jiayi Sun ^a ,
Jingyang Li ^a ,
Xi Li ^b ,
Lu Yang ^a ,
Yitong Liu ^{c, *,} ,
Huile Gao ^d ,
Li Xiang ^{a, *,}

a.
State Key Laboratory of Southwestern Chinese Medicine Resources, Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
b.
Public Health Clinical Center of Chengdu, Chengdu 610061, China
c.
The Third Affiliated Hospital of Chengdu University of TCM/Chengdu Pidu District Hospital of Traditional Chinese Medicine, Chengdu 611730, China
d.
West China School of Pharmacy, Sichuan University, Chengdu 610041, China

Liuxsc1989@126.com

xianglydr@cdutcm.edu.cn

Received Date: 6 August 2022
Revised Date: 6 October 2022
Accepted Date: 7 October 2022
Available Online: 13 October 2022

Figures(4)

Poor tumor accumulation remains a serious challenge for nanomedicines to achieve ideal antitumor outcomes. The different size preferences for systematic circulation, tumor retention and deep permeation have attracted great attention when designing antineoplastic nano-delivery system. Herein, we developed a nano-system which can shrink its size in tumor microenvironment to achieve better tumor retention and penetration. In this work, the cationic bovine serum albumin-protected, doxorubicin-loaded gold nanoclusters (CAuNC-DOX) and amino-functionalized mesoporous silica nanoparticles (MSN) are connected by Fe²⁺ and are further coated with hyaluronic acid (HA) to obtain a core-satellite MSN-Fe-CAuNC-DOX@HA nano system (MFADH). When reaching the tumor site, the HA shell, which endows the system with both good biocompatibility and preferable tumor targeting ability, was disintegrated, followed by acid-stimulated release of small-sized pharmacological unit—CAuNC-DOX for further tumor penetration. As demonstrated in both in vitro and in vivo results, MFADH showed excellent antitumor effect, providing a proof of concept for the feasibility of shrinkable nanoplatforms in tumor treatment.
- Size reducible,
- Tumor penetration,
- Core-satellite structure,
- Mesoporous silica nanoparticles,
- Gold nanoclusters,
- Experimental techniques
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