Citation: Siqi Wang, Jian-Shu Wang, Jun Ying, Xiao-Feng Wu. Palladium-catalyzed carbonylative cyclization of alkene-tethered indoles with phenols or arylboronic acids: Construction of carbonyl-containing indolo[2,1-a]isoquinoline derivatives[J]. Chinese Chemical Letters, ;2023, 34(5): 107873. doi: 10.1016/j.cclet.2022.107873 shu

Palladium-catalyzed carbonylative cyclization of alkene-tethered indoles with phenols or arylboronic acids: Construction of carbonyl-containing indolo[2,1-a]isoquinoline derivatives

Siqi Wang ^a ,
Jian-Shu Wang ^a ,
Jun Ying ^{a, *,} ,
Xiao-Feng Wu ^{b, c, *,}

a.
Department of Chemistry, Key Laboratory of Surface & Interface Science of Polymer Materials of Zhejiang Province, Zhejiang Sci-Tech University, Hangzhou 310018, China
b.
Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
c.
Leibniz-Institut für Katalyse e. V., Albert-Einstein-Straβe 29a, Rostock 18059, Germany

yingjun@zstu.edu.cn

xwu2020@dicp.ac.cn

xiaofeng.wu@catalysis.de

Received Date: 12 August 2022
Revised Date: 26 September 2022
Accepted Date: 29 September 2022
Available Online: 1 October 2022

Figures(5)

A novel palladium-catalyzed carbonylative cyclization of alkene-tethered indoles with phenols or arylboronic acids is described, which provides a facile approach to access indolo[2,1-a]isoquinoline scaffolds. This method employs benzene-1,3,5-triyl triformate (TFBen) as the CO surrogate for the incorporation of a carbonyl group into indolo[2,1-a]isoquinoline scaffolds, and a variety of carbonyl-containing indolo[2,1-a]isoquinoline derivatives are prepared in good yields.
- Carbonylative cyclization,
- Palladium catalysis,
- Indolo[2,1-a]isoquinolines,
- Alkene-tethered indoles,
- Phenols,
- Arylboronic acids
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