Citation: Jianhui Zuo, Xin Gao, Jianru Xiao, Yiyun Cheng. Carrier-free supramolecular nanomedicines assembled by small-molecule therapeutics for cancer treatment[J]. Chinese Chemical Letters, ;2023, 34(5): 107827. doi: 10.1016/j.cclet.2022.107827 shu

Carrier-free supramolecular nanomedicines assembled by small-molecule therapeutics for cancer treatment

Jianhui Zuo ^{a, 1} ,
Xin Gao ^{b, c, 1} ,
Jianru Xiao ^{b, c, *,} ,
Yiyun Cheng ^{b, *,}

a.
Department of Thoracic Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
b.
Shanghai Changzheng Hospital Joint Research Center for Orthopedic Oncology, East China Normal University, Shanghai 200241, China
c.
Department of Orthopedics Oncology, Changzheng Hospital, Navy Medical University, Shanghai 200003, China

jianruxiao83@163.com

yycheng@mail.ustc.edu.cn

Received Date: 20 June 2022
Revised Date: 13 September 2022
Accepted Date: 14 September 2022
Available Online: 19 September 2022

Figures(11)

Nanomedicines have shown great promise in cancer therapy, but are challenged by limited drug loading, safety concerns of drug carriers, and complexity of function integration. Recently, carrier-free nanomedicines produced by supramolecular assembly of small-molecule therapeutic functionalities and their conjugates were proposed to address these issues. These nanomedicines achieve very high drug loading, enhanced tumor accumulation and improved therapeutic efficiency, and avoid carrier-related safety problems. In this review article, the applications of these nanomedicines in chemotherapy, photodynamic therapy, photothermal therapy as well as combination therapies will be reviewed. The concept of nanomedicine design and mechanism of supramolecular assembly will be discussed. Finally, future perspectives of carrier-free supramolecular nanomedicines for cancer therapy will be highlighted.
- Nanomedicine,
- Carrier-free,
- Cancer therapy,
- Supramolecular assembly,
- Combination therapy
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沈阳化工大学材料科学与工程学院沈阳 110142