Citation: Chang Xu, Yue Kang, Shiqiang Guan, Xufeng Dong, Daqing Jiang, Min Qi. Iron-based metal–organic framework as a dual cooperative release system for enhanced vascularization and bone regeneration[J]. Chinese Chemical Letters, ;2023, 34(5): 107825. doi: 10.1016/j.cclet.2022.107825 shu

Iron-based metal–organic framework as a dual cooperative release system for enhanced vascularization and bone regeneration

Chang Xu ^a ,
Yue Kang ^b ,
Shiqiang Guan ^a ,
Xufeng Dong ^{a, *,} ,
Daqing Jiang ^b ,
Min Qi ^{a, *,}

a.
School of Materials Science and Engineering, Dalian University of Technology, Dalian 116024, China
b.
Department of Breast Surgery, Cancer Hospital of China Medical University, Shenyang 110042, China

dongxf@dlut.edu.cn

minqi@dlut.edu.cn

Received Date: 8 July 2022
Revised Date: 9 September 2022
Accepted Date: 13 September 2022
Available Online: 15 September 2022

Figures(4)

Vascularization and bone regeneration are closely related in the process of bone remodeling, and designing a bioactive scaffold with pro-angiogenic and osteogenic properties may accelerate the repair of bone defects. In this work, an iron-based metal–organic framework (MIL-88) was developed as a carrier for loading a pro-angiogenic small molecular drug (dimethyloxallyl glycine, DMOG), and then embedded into the PLGA nanofibrous scaffolds to repair cranial defects in rats. Imaging and histological evaluation indicated that PLGA/MIL@D scaffold markedly enhanced vascularization and bone regeneration in vivo. Moreover, in vitro assay showed that co-delivery system significantly promoted angiogenesis by stimulating endothelial cell migration, tube formation, and enhanced osteogenesis by promoting expression of osteoblast related proteins. In addition, PLGA/MIL@D scaffold promotes angiogenesis by activating the hypoxia-inducible factor-1 (HIF-1)/vascular endothelial growth factor (VEGF) signaling pathway. Altogether, this bioactive PLGA/MIL@D scaffold can combine angiogenesis with osteogenesis, and will be a bright strategy for the repair of bone defects.
- Osteogenesis,
- Angiogenesis,
- DMOG,
- Metal-organic framework,
- Bone regeneration
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