Citation: Wenxuan Sun, Zijia Liu, Jian Xu, Ya Cheng, Ruixue Yin, Lei Ma, Honglin Li, Xuhong Qian, Hongbo Zhang. 3D skin models along with skin-on-a-chip systems: A critical review[J]. Chinese Chemical Letters, ;2023, 34(5): 107819. doi: 10.1016/j.cclet.2022.107819 shu

3D skin models along with skin-on-a-chip systems: A critical review

Wenxuan Sun ^a ,
Zijia Liu ^a ,
Jian Xu ^b ,
Ya Cheng ^b ,
Ruixue Yin ^a ,
Lei Ma ^c ,
Honglin Li ^c ,
Xuhong Qian ^{c, d} ,
Hongbo Zhang ^{a, *,}

a.
School of Mechanical and Power Engineering, East China University of Science and Technology, Shanghai 200237, China
b.
School of Physics and Electronic Science, East China Normal University, Shanghai 200062, China
c.
School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
d.
School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China

hbzhang@ecust.edu.cn

Received Date: 29 June 2022
Revised Date: 2 September 2022
Accepted Date: 9 September 2022
Available Online: 13 September 2022

Figures(1)

Skin is the largest organ in human body, and it plays an important role in regulating physiological microenvironments and acts as a barrier to protect human body from harmful intrusions. The demand for fully functional skin models (also called skin equivalents, SE) in an in-vivo mimicking culturing microenvironment has been increased dramatically due to the fast development in skin disease treatments and skin care products. Owing to the emerging of the concept and technology of organ-on-chips along with the three-dimensional (3D) bioprinting technology, 3D skin models and their applications have been fast evolving. In this paper, the advances in the development of 3D skin models along with skin-on-a-chip (SOC) are reviewed and commented. One of the findings with this paper is that the SOC together with the 3D bioprinting technology is promising to construct fully functional 3D skin models in the field of pharmaceutical and cosmetic industries.
- 3D skin model,
- Skin equivalent,
- Skin-on-a-chip,
- 3D bioprinting,
- Skin barrier
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沈阳化工大学材料科学与工程学院沈阳 110142