Citation: Yuhan Sun, He Zhang, Guangzhao Lu, Huan Wang, Ying Lu, Li Fan. Mitochondria-targeted cancer therapy based on functional peptides[J]. Chinese Chemical Letters, ;2023, 34(5): 107817. doi: 10.1016/j.cclet.2022.107817 shu

Mitochondria-targeted cancer therapy based on functional peptides

Department of Pharmaceutical Sciences, School of Pharmacy, Naval Medical University, Shanghai 200433, China

acuace@163.com

fanli7062022@163.com

Received Date: 16 June 2022
Revised Date: 7 September 2022
Accepted Date: 9 September 2022
Available Online: 13 September 2022

Figures(3)

Mitochondria are critical for tumor growth and metastasis. A number of traditional antitumor drugs have poor water solubility and must penetrate multiple cellular barriers to reach the mitochondria. Because mitochondria have a unique transmembrane potential and an inner membrane with a low permeability, it is difficult for most drugs to enter mitochondria. In recent years, mitochondria-targeted delivery systems that use functional peptides to modify drugs have received increasing attention. Introducing functional peptides can change the original physicochemical properties of drugs and actively target mitochondria. Functional peptide-drug conjugates (PDCs, peptide-drug conjugates) can decompose and release drugs over time or due to certain stimuli in tumors. This preserves the biological activity of the drug while increasing intratumor uptake through the enhanced permeability and retention effect (EPR, the enhanced permeability and retention effect). In this review, we focus on the direction of cancer therapy and review the application of different functional peptides in the mitochondria-targeted tumor treatments reported in recent years.
- Peptides,
- Mitochondria,
- Cancer therapy,
- Targeting,
- Cell uptake
1. [1]
  A.J. Roger, S.A. Muñoz-Gómez, R. Kamikawa, Curr. Biol. 27(2017) R1177-R1192. doi: 10.1016/j.cub.2017.09.015
2. [2]
  P. Ning, W. Wang, M. Chen, Y. Feng, X. Meng, Chin. Chem. Lett. 28(2017) 1943–1951. doi: 10.1016/j.cclet.2017.09.026
3. [3]
  M.J. Devine, J.T. Kittler, Nat. Rev. Neurosci. 19(2018) 63–80.
4. [4]
  J. Döhla, E. Kuuluvainen, N. Gebert, et al., Nat. Cell Biol. 24(2022) 148–154. doi: 10.1038/s41556-021-00837-0
5. [5]
  G. Siasos, V. Tsigkou, M. Kosmopoulos, et al., Ann. Transl. Med. 6(2018) 256–278. doi: 10.21037/atm.2018.06.21
6. [6]
  S. Fulda, L. Galluzzi, G. Kroemer, Nat. Rev. Drug Discov. 9(2010) 447–464. doi: 10.1038/nrd3137
7. [7]
  T. Hu, Z. Qin, C. Shen, H.L. Gong, Z.Y. He, Front. Bioeng. Biotechnol. 9(2021) 786621. doi: 10.3389/fbioe.2021.786621
8. [8]
  P.J. Burke, Trends Cancer 3(2017) 857–870. doi: 10.1016/j.trecan.2017.10.006
9. [9]
  X.S. Hou, H.S. Wang, B.P. Mugaka, G.J. Yang, Y. Ding, Biomater. Sci. 6(2018) 2786–2797. doi: 10.1039/C8BM00673C
10. [10]
  Y. Huang, T. Wang, Q. Tan, et al., Int. J. Nanomed. 16(2021) 4117–4146. doi: 10.2147/IJN.S315368
11. [11]
  B. Kalyanaraman, G. Cheng, M. Hardy, et al., Redox Biol. 14(2018) 316–327. doi: 10.1016/j.redox.2017.09.020
12. [12]
  K. Klein, K. He, A.I. Younes, et al., Front. Immunol. 11(2020) 573326. doi: 10.3389/fimmu.2020.573326
13. [13]
  S. Missiroli, M. Perrone, I. Genovese, P. Pinton, C. Giorgi, eBioMedicine 59(2020) 102943. doi: 10.1016/j.ebiom.2020.102943
14. [14]
  P.E. Porporato, N. Filigheddu, J.M.B. Pedro, G. Kroemer, L. Galluzzi, Cell Res. 28(2018) 265–280. doi: 10.1038/cr.2017.155
15. [15]
  S. Srinivasan, M. Guha, A. Kashina, N.G. Avadhani, Biochim. Biophys. Acta Bioenerg. 1858(2017) 602–614. doi: 10.1016/j.bbabio.2017.01.004
16. [16]
  W.X. Zong, J.D. Rabinowitz, E. White, Mol. Cell 61(2016) 667–676. doi: 10.1016/j.molcel.2016.02.011
17. [17]
  M.T. Jeena, S. Kim, S. Jin, J.H. Ryu, Cancers 12(2019) 26–46. doi: 10.3390/cancers12010026
18. [18]
  H. Qi, Y. Xu, P. Hu, C. Yao, D. Yang, Chin. Chem. Lett. 33(2022) 1131–1140. doi: 10.1016/j.cclet.2021.09.026
19. [19]
  K.G. Roth, I. Mambetsariev, P. Kulkarni, R. Salgia, Trends Mol. Med. 26(2020) 119–134.
20. [20]
  Y. Sun, A. Zhan, S. Zhou, et al., Chin. Chem. Lett. 30(2019) 1435–1439. doi: 10.1016/j.cclet.2019.05.001
21. [21]
  Y. Gao, H. Tong, J. Li, et al., Front. Bioeng. Biotechnol. 9(2021) 720508. doi: 10.3389/fbioe.2021.720508
22. [22]
  Z. Ma, Y. Zhang, J. Zhang, et al., ACS Appl. Mater. Interfaces 12(2020) 39434–39443. doi: 10.1021/acsami.0c11469
23. [23]
  R.C. Scaduto Jr., L.W. Grotyohann, Biophys. J. 76(1999) 469–477. doi: 10.1016/S0006-3495(99)77214-0
24. [24]
  E.K. Lei, S.O. Kelley, J. Am. Chem. Soc. 139(2017) 9455–9458. doi: 10.1021/jacs.7b04415
25. [25]
  W. Mitchell, E.A. Ng, J.D. Tamucci, et al., J. Biol. Chem. 295(2020) 7452–7469. doi: 10.1074/jbc.RA119.012094
26. [26]
  H.H. Szeto, AAPS J. 8(2006) E277–E283. doi: 10.1007/BF02854898
27. [27]
  M.P. Murphy, R.C. Hartley, Nat. Rev. Drug Discov. 17(2018) 865–886. doi: 10.1038/nrd.2018.174
28. [28]
  J. Zielonka, J. Joseph, A. Sikora, et al., Chem. Rev. 117(2017) 10043–10120. doi: 10.1021/acs.chemrev.7b00042
29. [29]
  Y. Bae, M.K. Jung, S.J. Song, et al., Mitochondrion 37(2017) 27–40. doi: 10.1016/j.mito.2017.06.005
30. [30]
  C. Bailly, Biochem. Pharmacol. 186(2021) 114467. doi: 10.1016/j.bcp.2021.114467
31. [31]
  S. Hong, X. Zhang, R.J. Lake, et al., Chem. Sci. 11(2019) 713–720.
32. [32]
  M. Shi, J. Zhang, X. Li, et al., Int. J. Nanomed. 13(2018) 4209–4226. doi: 10.2147/IJN.S163858
33. [33]
  V. Weissig, M. Lozoya, N. Yu, G.G.M. D'Souza, Methods Mol. Biol. 2275(2021) 13–25.
34. [34]
  Y. Feng, G. Qin, S. Chang, et al., Int. J. Nanomed. 16(2021) 3073–3089. doi: 10.2147/IJN.S297716
35. [35]
  D.A. Kuznetsova, G.A. Gaynanova, L.A. Vasileva, et al., J. Mater. Chem. B 7(2019) 7351–7362. doi: 10.1039/C9TB01853K
36. [36]
  C. Yue, Y. Yang, J. Song, et al., Nanoscale 9(2017) 11103–11118. doi: 10.1039/C7NR02193C
37. [37]
  P. Ning, L. Huang, Y. Bao, et al., Bioconjug. Chem. 31(2020) 2719–2725. doi: 10.1021/acs.bioconjchem.0c00518
38. [38]
  O. Oladimeji, J. Akinyelu, M. Singh, J. Biomed. Nanotechnol. 16(2020) 853–866. doi: 10.1166/jbn.2020.2930
39. [39]
  W. Wang, J. Liu, W. Feng, et al., Biomater. Sci. 7(2019) 1052–1063. doi: 10.1039/C8BM01414K
40. [40]
  L. Luo, M. Wang, Y. Zhou, et al., Anal. Chem. 93(2021) 6715–6722. doi: 10.1021/acs.analchem.1c00176
41. [41]
  J. Yan, J. Chen, N. Zhang, et al., J. Mater. Chem. B 8(2020) 492–503. doi: 10.1039/C9TB02266J
42. [42]
  L.H. Dian, Y.J. Hu, J.Y. Lin, et al., Int. J. Nanomed. 13(2018) 719–731. doi: 10.2147/IJN.S150140
43. [43]
  Z. Fan, B. Jiang, D. Shi, et al., Int. J. Pharm. 594(2021) 120184. doi: 10.1016/j.ijpharm.2020.120184
44. [44]
  H. Wang, W. Shi, D. Zeng, et al., J. Nanobiotechnol. 19(2021) 152. doi: 10.1186/s12951-021-00895-4
45. [45]
  H. Wang, F. Zhang, H. Wen, et al., J. Nanobiotechnol. 18(2020) 8–27. doi: 10.1186/s12951-019-0562-3
46. [46]
  Y. Zhang, C. Zhang, J. Chen, et al., ACS Appl. Mater. Interfaces 9(2017) 25152–25163. doi: 10.1021/acsami.7b07219
47. [47]
  S. Tang, Z. Davoudi, G. Wang, et al., Chem. Soc. Rev. 50(2021) 12679–12701. doi: 10.1039/D1CS00029B
48. [48]
  J. Xu, W. Du, Y. Zhao, et al., Acta Pharm. Sin. B 12(2022) 2778–2789. doi: 10.1016/j.apsb.2022.03.001
49. [49]
  L. Huang, Z. Sun, Q. Shen, et al., Chin. Chem. Lett. 33(2022) 4146–4156. doi: 10.1016/j.cclet.2022.02.047
50. [50]
  Y. Wang, A.G. Cheetham, G. Angacian, et al., Adv. Drug Deliv. Rev. 110-111(2017) 112–126. doi: 10.1016/j.addr.2016.06.015
51. [51]
  N. Mehrotra, S. Kharbanda, H. Singh, Nanomedicine (Lond) 15(2020) 2201–2217. doi: 10.2217/nnm-2020-0220
52. [52]
  Z. Luo, Y. Gao, Z. Duan, Y. Yi, H. Wang, Front. Bioeng. Biotechnol. 9(2021) 782234. doi: 10.3389/fbioe.2021.782234
53. [53]
  X. Li, W. Zhang, Q. Cao, et al., Cell Death Discov. 6(2020) 80–94.
54. [54]
  D. Liu, A. Angelova, J. Liu, et al., J. Mater. Chem. B 7(2019) 4706–4716. doi: 10.1039/C9TB00629J
55. [55]
  R.W. Taylor, D.M. Turnbull, Nat. Rev. Genet. 6(2005) 389–402. doi: 10.1038/nrg1606
56. [56]
  C.S. Burke, A. Byrne, T.E. Keyes, Angew. Chem. Int. Ed. 57(2018) 12420–12424. doi: 10.1002/anie.201806002
57. [57]
  P.F. Chinnery, G. Hudson, Br. Med. Bull. 106(2013) 135–159. doi: 10.1093/bmb/ldt017
58. [58]
  A.W. El-Hattab, W.J. Craigen, F. Scaglia, Biochim. Biophys. Acta Mol. Basis Dis. 1863(2017) 1539–1555. doi: 10.1016/j.bbadis.2017.02.017
59. [59]
  A. Klimpel, I. Neundorf, J. Control. Release 291(2018) 147–156. doi: 10.1016/j.jconrel.2018.10.029
60. [60]
  H. Li, W. Xu, F. Li, et al., Drug Deliv. 29(2022) 192–202. doi: 10.1080/10717544.2021.2023697
61. [61]
  M. Kleih, K. Bopple, M. Dong, et al., Cell Death Dis. 10(2019) 851–863. doi: 10.1038/s41419-019-2081-4
62. [62]
  G. Calmettes, B. Ribalet, S. John, et al., J. Mol. Cell Cardiol. 78(2015) 107–115. doi: 10.1016/j.yjmcc.2014.09.020
63. [63]
  G.S. Krasnov, A.A. Dmitriev, V.A. Lakunina, A.A. Kirpiy, A.V. Kudryavtseva, Expert Opin. Ther. Targets 17(2013) 1221–1233. doi: 10.1517/14728222.2013.833607
64. [64]
  S.P. Mathupala, Y.H. Ko, P.L. Pedersen, Oncogene 25(2006) 4777–4786. doi: 10.1038/sj.onc.1209603
65. [65]
  J.G. Pastorino, J.B. Hoek, Curr. Med. Chem. 10(2003) 1535–1551. doi: 10.2174/0929867033457269
66. [66]
  J.G. Pastorino, J.B. Hoek, J. Bioenerg. Biomembr. 40(2008) 171–182. doi: 10.1007/s10863-008-9148-8
67. [67]
  S. Reina, V. De Pinto, Curr. Med. Chem. 24(2017) 4447–4469.
68. [68]
  V. Shoshan-Barmatz, D. Ben-Hail, L. Admoni, Y. Krelin, S.S. Tripathi, Biochim. Biophys. Acta 1848(2015) 2547–2575. doi: 10.1016/j.bbamem.2014.10.040
69. [69]
  R.J. Winquist, V.K. Gribkoff, Biochem. Pharmacol. 177(2020) 113995. doi: 10.1016/j.bcp.2020.113995
70. [70]
  A. Magri, A. Messina, Curr. Med. Chem. 24(2017) 4470–4487.
71. [71]
  A.G. Assanhou, W. Li, L. Zhang, et al., Biomaterials 73(2015) 284–295. doi: 10.1016/j.biomaterials.2015.09.022
72. [72]
  Y. Liu, X. Zhang, M. Zhou, et al., ACS Appl. Mater. Interfaces 9(2017) 43498–43507. doi: 10.1021/acsami.7b14577
73. [73]
  S. Zhang, A. Long, A.J. Link, ACS Synth. Biol. 1(2012) 89–98. doi: 10.1021/sb200002m
74. [74]
  T.O. Jose-Luis Diaz, W. Horne, M. McConnell, et al., J. Biol. Chem. 17(1997) 11350–11355.
75. [75]
  F. Llambi, D.R. Green, Curr. Opin. Genet. Dev. 21(2011) 12–20. doi: 10.1016/j.gde.2010.12.001
76. [76]
  A. Shteinfer-Kuzmine, Z. Amsalem, T. Arif, A. Zooravlov, V. Shoshan-Barmatz, Mol. Oncol. 12(2018) 1077–1103. doi: 10.1002/1878-0261.12313
77. [77]
  M. Li, Y. Song, N. Song, et al., Nano. Lett. 21(2021) 5730–5737. doi: 10.1021/acs.nanolett.1c01469
78. [78]
  M.T. Jeena, L. Palanikumar, E.M. Go, et al., Nat. Commun. 8(2017) 26. doi: 10.1038/s41467-017-00047-z
79. [79]
  S. Kim, H.Y. Nam, J. Lee, J. Seo, Biochemistry 59(2020) 270–284. doi: 10.1021/acs.biochem.9b00857
80. [80]
  R. Lin, P. Zhang, A.G. Cheetham, et al., Bioconjug. Chem. 26(2015) 71–77. doi: 10.1021/bc500408p
81. [81]
  A.D. Woldetsadik, M.C. Vogel, W.M. Rabeh, M. Magzoub, FASEB J. 31(2017) 2168–2184. doi: 10.1096/fj.201601173R
82. [82]
  Q. Li, J. Yang, C. Chen, et al., J. Control. Release 325(2020) 38–51. doi: 10.1016/j.jconrel.2020.06.010
83. [83]
  A. Liu, X. Hou, Y. Ding, Y., Acta Pharm. Sin. 52(2017) 879–887.
84. [84]
  V. Gogvadze, S. Orrenius, B. Zhivotovsky, Biochim. Biophys. Acta 1757(2006) 639–647. doi: 10.1016/j.bbabio.2006.03.016
85. [85]
  H.Y. Chiu, E.X.Y. Tay, D.S.T. Ong, R. Taneja, Antioxid. Redox Signal. 32(2020) 309–330. doi: 10.1089/ars.2019.7898
86. [86]
  J. Wu, J. Li, H. Wang, C.B. Liu, Expert Opin. Drug Deliv. 15(2018) 951–964. doi: 10.1080/17425247.2018.1517750
87. [87]
  K.L. Horton, K.M. Stewart, S.B. Fonseca, Q. Guo, S.O. Kelley, Chem. Biol. 15(2008) 375–382. doi: 10.1016/j.chembiol.2008.03.015
88. [88]
  T. Zhao, X. Liu, S. Singh, et al., Bioconjug. Chem. 30(2019) 2312–2316. doi: 10.1021/acs.bioconjchem.9b00465
89. [89]
  Y. Deng, F. Jia, X. Chen, Q. Jin, J. Ji, Small 16(2020) e2001747. doi: 10.1002/smll.202001747
90. [90]
  J. Yang, Q. Li, M. Zhou, et al., Int. J. Pharm. 608(2021) 121077. doi: 10.1016/j.ijpharm.2021.121077
91. [91]
  P.P. Czupiel, V. Delplace, M.S. Shoichet, J. Control. Release 305(2019) 210–219. doi: 10.1016/j.jconrel.2019.04.045
92. [92]
  M. Abbas, Q. Zou, S. Li, X. Yan, Adv. Mater. 29(2017) 1605021. doi: 10.1002/adma.201605021
93. [93]
  Z.H. Wang, L. Chen, W. Li, L. Chen, Y.P. Wang, Mitochondrion 65(2022) 80–87. doi: 10.1016/j.mito.2022.05.002
94. [94]
  Z. Zheng, P. Chen, M. Xie, et al., J. Am. Chem. Soc. 138(2016) 11128–11131. doi: 10.1021/jacs.6b06903
95. [95]
  J. Zhou, X. Du, C. Berciu, et al., Chem 1(2016) 246–263. doi: 10.1016/j.chempr.2016.07.003
96. [96]
  J. Zhou, X. Du, N. Yamagata, B. Xu, J. Am. Chem. Soc. 138(2016) 3813–3823. doi: 10.1021/jacs.5b13541
97. [97]
  Q. Yao, Z. Huang, D. Liu, J. Chen, Y. Gao, Adv. Mater. 31(2019) e1804814. doi: 10.1002/adma.201804814
98. [98]
  H. Wang, Z. Feng, Y. Wang, et al., J. Am. Chem. Soc. 138(2016) 16046–16055. doi: 10.1021/jacs.6b09783
99. [99]
  J. Wang, Q. Zhou, X. Li, D. Dutta, Z. Ge, A.C.S. Macro, Lett. 11(2022) 543–548.
100. [100]
  P. Zhu, X. Yan, Y. Su, Y. Yang, J. Li, Chemistry (Easton) 16(2010) 3176–3183.
101. [101]
  P.C. Saha, T. Bera, T. Chatterjee, et al., Bioconjug. Chem. 32(2021) 833–841. doi: 10.1021/acs.bioconjchem.1c00106
102. [102]
  D. Zhang, G.B. Qi, Y.X. Zhao, et al., Adv. Mater. 27(2015) 6125–6130. doi: 10.1002/adma.201502598
103. [103]
  X.H. Zhang, D.B. Cheng, L. Ji, et al., Nano. Lett. 20(2020) 1286–1295. doi: 10.1021/acs.nanolett.9b04752
104. [104]
  D.B. Cheng, X.H. Zhang, Y.J. Gao, et al., J. Am. Chem. Soc. 141(2019) 7235–7239. doi: 10.1021/jacs.8b07727
105. [105]
  X. Jin, H. Yang, Z. Mao, B. Wang, J. Colloid Interface Sci. 601(2021) 714–726. doi: 10.1016/j.jcis.2021.05.135
106. [106]
  L. Wu, B. Lin, H. Yang, et al., Acta Biomater. 86(2019) 363–372. doi: 10.1016/j.actbio.2019.01.026
107. [107]
  Z. Feng, H. Wang, F. Wang, et al., Cell Rep. Phys. Sci. 1(2020) 100085. doi: 10.1016/j.xcrp.2020.100085
108. [108]
  PEPAXTO Prescribing Information, U.S. FOOD & DRUG ADMINISTRATION, 2020, https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process [2022-06-17].
109. [109]
  LUTATHERA Prescribing Information, U.S. FOOD & DRUG ADMINISTRATION, 2020, https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process [2022-06-17].
110. [110]
  K. Fosgerau, T. Hoffmann, Drug Discov. Today 20(2015) 122–128. doi: 10.1016/j.drudis.2014.10.003
111. [111]
  Safety, Efficacy & Pharmacokinetics of Elamipretide, clinicaltrials. gov, 2020, http://clinicaltrials.gov/ct2/show/NCT03323749 [2022-06-17].
112. [112]
  Safety and Efficacy of Elamipretide Primary Mitochondrial Myopathy, clinicaltrials. gov, 2020, http://clinicaltrials.gov/ct2/show/NCT03323749 [2022-06-17].
1. [1]
  Xin Li , Fei Xiong , Xudong Cao , Wei Liu , Haobo Chen , Jiayu He , Weina Zhang , Longguang Tang , Wei Huang , Xikuang Yao . CD44-targeting and ZIF-8 gated gold nanocage for programmed breast cancer therapy through Pt-induced immunogenic cell death. Chinese Chemical Letters, 2026, 37(1): 110970-. doi: 10.1016/j.cclet.2025.110970
2. [2]
  Kun-Heng Li , Hong-Yang Zhao , Dan-Dan Wang , Ming-Hui Qi , Zi-Jian Xu , Jia-Mi Li , Zhi-Li Zhang , Shi-Wen Huang . Mitochondria-targeted nano-AIEgens as a powerful inducer for evoking immunogenic cell death. Chinese Chemical Letters, 2024, 35(5): 108882-. doi: 10.1016/j.cclet.2023.108882
3. [3]
  Zhaoyong Kang , Shen Li , Yan Li , Jingfeng Song , Yangrui Peng , Yihua Chen . Small molecular inhibitors and degraders targeting STAT3 for cancer therapy: An updated review (from 2022 to 2024). Chinese Chemical Letters, 2025, 36(7): 110447-. doi: 10.1016/j.cclet.2024.110447
4. [4]
  Junjie Wang , Yan Wang , Zhengdong Li , Changqiang Xie , Musammir Khan , Xingzhou Peng , Fabiao Yu . Triphenylamine-AIEgens photoactive materials for cancer theranostics. Chinese Chemical Letters, 2024, 35(6): 108934-. doi: 10.1016/j.cclet.2023.108934
5. [5]
  Huiyang Chen , Zibo Li , Xiaoying Li , Chenhong Tang , Xiaoyu Liu , Minyi Nie , Ying Huang , Xiaoyu Chen , Kuncai Liu , Yilan Dai , Qiaoling Zhang , Ling Lin , Siming Zhang , Bingchen Zhang , Zhiqiang Yu . A novel mitochondria-targeted nanoprodrug amplifies oxidative stress to enhance cisplatin chemotherapy for the treatment of hepatocellular carcinoma. Chinese Chemical Letters, 2025, 36(10): 111313-. doi: 10.1016/j.cclet.2025.111313
6. [6]
  Menglin Zhang , Fanpeng Ran , Yun Zhang , Xiaoli Zhang , Zhigang Xu , Xiaoxiao Shi . Cyclodextrin-based nanotherapeutics: A promising strategy for enhanced cancer therapy. Chinese Chemical Letters, 2026, 37(1): 111232-. doi: 10.1016/j.cclet.2025.111232
7. [7]
  Hao Hu , Jiacheng Wang , Si Zhang , Ben Zhang , Cuinan Jiang , Hong Tian , Xunxin Gu , Yang Sheng , Zhenghuan Zhao , Meng Li , Lu Zheng , Jing Li . Hierarchical and flexible electrode with precise H₂-production for in vivo liver cancer therapy. Chinese Chemical Letters, 2025, 36(12): 110866-. doi: 10.1016/j.cclet.2025.110866
8. [8]
  Dechao Yuan , Tianying Luo , Qiao Su , Changxing Qu , Meng Pan , Jia Xu , Mingyi Zhang , Yuanchao Luo , Renjian He , Shiwei Liu , Xiang Fang , Hong Duan , Zhiyong Qian . Nanozyme-based catalytic therapeutics: Applications in infectious diseases, cancer therapy, and bone regeneration. Chinese Chemical Letters, 2026, 37(3): 111842-. doi: 10.1016/j.cclet.2025.111842
9. [9]
  Shengyi Gong , Guoqiang Feng . Visible light-triggered NIR ratiometric fluorescent metal-free CO-releasing molecule for self-monitoring of CO delivery and effective cancer therapy. Chinese Chemical Letters, 2025, 36(7): 110409-. doi: 10.1016/j.cclet.2024.110409
10. [10]
  Yuanyi Zhou , Ke Ma , Jinfeng Liu , Zirun Zheng , Bo Hu , Yu Meng , Zhizhong Li , Mingshan Zhu . Is reactive oxygen species the only way for cancer inhibition over single atom nanomedicine? Autophagy regulation also works. Chinese Chemical Letters, 2024, 35(6): 109056-. doi: 10.1016/j.cclet.2023.109056
11. [11]
  Yupeng Wang , Xinxin Sun , Jianbin Shi , Zhixiao Zhang , Jin Sun , Cong Luo , Zhonggui He , Shenwu Zhang . Chain architecture-engineered artesunate nanoassemblies target LONP1 to induce oxidative damage for enhanced anti-tumor therapy. Chinese Chemical Letters, 2026, 37(1): 111609-. doi: 10.1016/j.cclet.2025.111609
12. [12]
  Fengjie Liu , Fansu Meng , Zhenjiang Yang , Huan Wang , Yuehong Ren , Yu Cai , Xingwang Zhang . Exosome-biomimetic nanocarriers for oral drug delivery. Chinese Chemical Letters, 2024, 35(9): 109335-. doi: 10.1016/j.cclet.2023.109335
13. [13]
  Jiayu Zeng , Minhui Liu , Ting Yang , Jia Huang , Songjiao Li , Wanting Zhang , Dan Cheng , Longwei He , Jia Zhou . Two-dimensional design strategy to construct smart dual-responsive fluorescent probe for the precise tracking of ischemic stroke. Chinese Chemical Letters, 2025, 36(5): 110166-. doi: 10.1016/j.cclet.2024.110166
14. [14]
  Ziqin Li , Kai Hao , Longwei Xiang , Huayu Tian . Cationic covalent organic framework nanocarriers integrating both efficient gene silencing and real-time gene detection. Chinese Chemical Letters, 2025, 36(4): 109943-. doi: 10.1016/j.cclet.2024.109943
15. [15]
  Yixin Sun , Keke Yu , Xiuchun Guo , Lanlan Zong , Zhonggui He , Xiaohui Pu . Three-in-one reduction and acid-ignited micelles amplify antitumor efficacy via precise synergistic delivery of paclitaxel and naringenin. Chinese Chemical Letters, 2025, 36(6): 110393-. doi: 10.1016/j.cclet.2024.110393
16. [16]
  Xuanbo Zhang , Feng Fang , Na Li , Huicong Zhang , Kaiyuan Wang , Zhiqiang Yu , Jin Sun . From reversible to irreversible: Albumin-hitchhiking gemcitabine prodrugs for enhanced antitumor efficacy and reduced toxicity. Chinese Chemical Letters, 2026, 37(2): 111452-. doi: 10.1016/j.cclet.2025.111452
17. [17]
  Ruhe Zhang , Dandan Li , Ting Liang , Xinyu Zhang , Jingyi Hou , Yang Kang , Dongjun Lin , Jun Wu . Dual redox-responsive CO₂-generating nanoparticles assembled from one-step synthesized L-cystine-based biodegradable polymers for enhanced chemotherapy of tumors. Chinese Chemical Letters, 2026, 37(7): 111680-. doi: 10.1016/j.cclet.2025.111680
18. [18]
  Panpan Wang , Hongbao Fang , Mengmeng Wang , Guandong Zhang , Na Xu , Yan Su , Hongke Liu , Zhi Su . A mitochondria targeting Ir(III) complex triggers ferroptosis and autophagy for cancer therapy: A case of aggregation enhanced PDT strategy for metal complexes. Chinese Chemical Letters, 2025, 36(1): 110099-. doi: 10.1016/j.cclet.2024.110099
19. [19]
  Baoqing Liu , Zimeng Li , Xiandong Shi , Jingyi Zhang , Heming Wu , Hailong Liu , Jiahong Zhou . An SCC-9 cell uptake-specific extracellular vesicle drug delivery system for tongue cancer therapy. Chinese Chemical Letters, 2026, 37(7): 111748-. doi: 10.1016/j.cclet.2025.111748
20. [20]
  Yirou Wang , Futing Yang , Jun Wang , Xinghua Liao , Chun Song , Michał Nowicki , Roman Szewczyk , Na Peng . Glutathione-activated mitochondria-targeting nanosystem overcoming ferroptosis defence for dual synergism with apoptosis to enhance anti-tumor efficacy of sonodynamic therapy. Chinese Chemical Letters, 2026, 37(8): 111771-. doi: 10.1016/j.cclet.2025.111771

Get Citation

PDF

XML

Metrics

PDF Downloads(19)
Abstract views(3832)
HTML views(228)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142