Citation: Yuhan Sun, He Zhang, Guangzhao Lu, Huan Wang, Ying Lu, Li Fan. Mitochondria-targeted cancer therapy based on functional peptides[J]. Chinese Chemical Letters, ;2023, 34(5): 107817. doi: 10.1016/j.cclet.2022.107817 shu

Mitochondria-targeted cancer therapy based on functional peptides

Department of Pharmaceutical Sciences, School of Pharmacy, Naval Medical University, Shanghai 200433, China

acuace@163.com

fanli7062022@163.com

Received Date: 16 June 2022
Revised Date: 7 September 2022
Accepted Date: 9 September 2022
Available Online: 13 September 2022

Figures(3)

Mitochondria are critical for tumor growth and metastasis. A number of traditional antitumor drugs have poor water solubility and must penetrate multiple cellular barriers to reach the mitochondria. Because mitochondria have a unique transmembrane potential and an inner membrane with a low permeability, it is difficult for most drugs to enter mitochondria. In recent years, mitochondria-targeted delivery systems that use functional peptides to modify drugs have received increasing attention. Introducing functional peptides can change the original physicochemical properties of drugs and actively target mitochondria. Functional peptide-drug conjugates (PDCs, peptide-drug conjugates) can decompose and release drugs over time or due to certain stimuli in tumors. This preserves the biological activity of the drug while increasing intratumor uptake through the enhanced permeability and retention effect (EPR, the enhanced permeability and retention effect). In this review, we focus on the direction of cancer therapy and review the application of different functional peptides in the mitochondria-targeted tumor treatments reported in recent years.
- Peptides,
- Mitochondria,
- Cancer therapy,
- Targeting,
- Cell uptake
1. [1]
  A.J. Roger, S.A. Muñoz-Gómez, R. Kamikawa, Curr. Biol. 27(2017) R1177-R1192. doi: 10.1016/j.cub.2017.09.015
2. [2]
  P. Ning, W. Wang, M. Chen, Y. Feng, X. Meng, Chin. Chem. Lett. 28(2017) 1943–1951. doi: 10.1016/j.cclet.2017.09.026
3. [3]
  M.J. Devine, J.T. Kittler, Nat. Rev. Neurosci. 19(2018) 63–80.
4. [4]
  J. Döhla, E. Kuuluvainen, N. Gebert, et al., Nat. Cell Biol. 24(2022) 148–154. doi: 10.1038/s41556-021-00837-0
5. [5]
  G. Siasos, V. Tsigkou, M. Kosmopoulos, et al., Ann. Transl. Med. 6(2018) 256–278. doi: 10.21037/atm.2018.06.21
6. [6]
  S. Fulda, L. Galluzzi, G. Kroemer, Nat. Rev. Drug Discov. 9(2010) 447–464. doi: 10.1038/nrd3137
7. [7]
  T. Hu, Z. Qin, C. Shen, H.L. Gong, Z.Y. He, Front. Bioeng. Biotechnol. 9(2021) 786621. doi: 10.3389/fbioe.2021.786621
8. [8]
  P.J. Burke, Trends Cancer 3(2017) 857–870. doi: 10.1016/j.trecan.2017.10.006
9. [9]
  X.S. Hou, H.S. Wang, B.P. Mugaka, G.J. Yang, Y. Ding, Biomater. Sci. 6(2018) 2786–2797. doi: 10.1039/C8BM00673C
10. [10]
  Y. Huang, T. Wang, Q. Tan, et al., Int. J. Nanomed. 16(2021) 4117–4146. doi: 10.2147/IJN.S315368
11. [11]
  B. Kalyanaraman, G. Cheng, M. Hardy, et al., Redox Biol. 14(2018) 316–327. doi: 10.1016/j.redox.2017.09.020
12. [12]
  K. Klein, K. He, A.I. Younes, et al., Front. Immunol. 11(2020) 573326. doi: 10.3389/fimmu.2020.573326
13. [13]
  S. Missiroli, M. Perrone, I. Genovese, P. Pinton, C. Giorgi, eBioMedicine 59(2020) 102943. doi: 10.1016/j.ebiom.2020.102943
14. [14]
  P.E. Porporato, N. Filigheddu, J.M.B. Pedro, G. Kroemer, L. Galluzzi, Cell Res. 28(2018) 265–280. doi: 10.1038/cr.2017.155
15. [15]
  S. Srinivasan, M. Guha, A. Kashina, N.G. Avadhani, Biochim. Biophys. Acta Bioenerg. 1858(2017) 602–614. doi: 10.1016/j.bbabio.2017.01.004
16. [16]
  W.X. Zong, J.D. Rabinowitz, E. White, Mol. Cell 61(2016) 667–676. doi: 10.1016/j.molcel.2016.02.011
17. [17]
  M.T. Jeena, S. Kim, S. Jin, J.H. Ryu, Cancers 12(2019) 26–46. doi: 10.3390/cancers12010026
18. [18]
  H. Qi, Y. Xu, P. Hu, C. Yao, D. Yang, Chin. Chem. Lett. 33(2022) 1131–1140. doi: 10.1016/j.cclet.2021.09.026
19. [19]
  K.G. Roth, I. Mambetsariev, P. Kulkarni, R. Salgia, Trends Mol. Med. 26(2020) 119–134.
20. [20]
  Y. Sun, A. Zhan, S. Zhou, et al., Chin. Chem. Lett. 30(2019) 1435–1439. doi: 10.1016/j.cclet.2019.05.001
21. [21]
  Y. Gao, H. Tong, J. Li, et al., Front. Bioeng. Biotechnol. 9(2021) 720508. doi: 10.3389/fbioe.2021.720508
22. [22]
  Z. Ma, Y. Zhang, J. Zhang, et al., ACS Appl. Mater. Interfaces 12(2020) 39434–39443. doi: 10.1021/acsami.0c11469
23. [23]
  R.C. Scaduto Jr., L.W. Grotyohann, Biophys. J. 76(1999) 469–477. doi: 10.1016/S0006-3495(99)77214-0
24. [24]
  E.K. Lei, S.O. Kelley, J. Am. Chem. Soc. 139(2017) 9455–9458. doi: 10.1021/jacs.7b04415
25. [25]
  W. Mitchell, E.A. Ng, J.D. Tamucci, et al., J. Biol. Chem. 295(2020) 7452–7469. doi: 10.1074/jbc.RA119.012094
26. [26]
  H.H. Szeto, AAPS J. 8(2006) E277–E283. doi: 10.1007/BF02854898
27. [27]
  M.P. Murphy, R.C. Hartley, Nat. Rev. Drug Discov. 17(2018) 865–886. doi: 10.1038/nrd.2018.174
28. [28]
  J. Zielonka, J. Joseph, A. Sikora, et al., Chem. Rev. 117(2017) 10043–10120. doi: 10.1021/acs.chemrev.7b00042
29. [29]
  Y. Bae, M.K. Jung, S.J. Song, et al., Mitochondrion 37(2017) 27–40. doi: 10.1016/j.mito.2017.06.005
30. [30]
  C. Bailly, Biochem. Pharmacol. 186(2021) 114467. doi: 10.1016/j.bcp.2021.114467
31. [31]
  S. Hong, X. Zhang, R.J. Lake, et al., Chem. Sci. 11(2019) 713–720.
32. [32]
  M. Shi, J. Zhang, X. Li, et al., Int. J. Nanomed. 13(2018) 4209–4226. doi: 10.2147/IJN.S163858
33. [33]
  V. Weissig, M. Lozoya, N. Yu, G.G.M. D'Souza, Methods Mol. Biol. 2275(2021) 13–25.
34. [34]
  Y. Feng, G. Qin, S. Chang, et al., Int. J. Nanomed. 16(2021) 3073–3089. doi: 10.2147/IJN.S297716
35. [35]
  D.A. Kuznetsova, G.A. Gaynanova, L.A. Vasileva, et al., J. Mater. Chem. B 7(2019) 7351–7362. doi: 10.1039/C9TB01853K
36. [36]
  C. Yue, Y. Yang, J. Song, et al., Nanoscale 9(2017) 11103–11118. doi: 10.1039/C7NR02193C
37. [37]
  P. Ning, L. Huang, Y. Bao, et al., Bioconjug. Chem. 31(2020) 2719–2725. doi: 10.1021/acs.bioconjchem.0c00518
38. [38]
  O. Oladimeji, J. Akinyelu, M. Singh, J. Biomed. Nanotechnol. 16(2020) 853–866. doi: 10.1166/jbn.2020.2930
39. [39]
  W. Wang, J. Liu, W. Feng, et al., Biomater. Sci. 7(2019) 1052–1063. doi: 10.1039/C8BM01414K
40. [40]
  L. Luo, M. Wang, Y. Zhou, et al., Anal. Chem. 93(2021) 6715–6722. doi: 10.1021/acs.analchem.1c00176
41. [41]
  J. Yan, J. Chen, N. Zhang, et al., J. Mater. Chem. B 8(2020) 492–503. doi: 10.1039/C9TB02266J
42. [42]
  L.H. Dian, Y.J. Hu, J.Y. Lin, et al., Int. J. Nanomed. 13(2018) 719–731. doi: 10.2147/IJN.S150140
43. [43]
  Z. Fan, B. Jiang, D. Shi, et al., Int. J. Pharm. 594(2021) 120184. doi: 10.1016/j.ijpharm.2020.120184
44. [44]
  H. Wang, W. Shi, D. Zeng, et al., J. Nanobiotechnol. 19(2021) 152. doi: 10.1186/s12951-021-00895-4
45. [45]
  H. Wang, F. Zhang, H. Wen, et al., J. Nanobiotechnol. 18(2020) 8–27. doi: 10.1186/s12951-019-0562-3
46. [46]
  Y. Zhang, C. Zhang, J. Chen, et al., ACS Appl. Mater. Interfaces 9(2017) 25152–25163. doi: 10.1021/acsami.7b07219
47. [47]
  S. Tang, Z. Davoudi, G. Wang, et al., Chem. Soc. Rev. 50(2021) 12679–12701. doi: 10.1039/D1CS00029B
48. [48]
  J. Xu, W. Du, Y. Zhao, et al., Acta Pharm. Sin. B 12(2022) 2778–2789. doi: 10.1016/j.apsb.2022.03.001
49. [49]
  L. Huang, Z. Sun, Q. Shen, et al., Chin. Chem. Lett. 33(2022) 4146–4156. doi: 10.1016/j.cclet.2022.02.047
50. [50]
  Y. Wang, A.G. Cheetham, G. Angacian, et al., Adv. Drug Deliv. Rev. 110-111(2017) 112–126. doi: 10.1016/j.addr.2016.06.015
51. [51]
  N. Mehrotra, S. Kharbanda, H. Singh, Nanomedicine (Lond) 15(2020) 2201–2217. doi: 10.2217/nnm-2020-0220
52. [52]
  Z. Luo, Y. Gao, Z. Duan, Y. Yi, H. Wang, Front. Bioeng. Biotechnol. 9(2021) 782234. doi: 10.3389/fbioe.2021.782234
53. [53]
  X. Li, W. Zhang, Q. Cao, et al., Cell Death Discov. 6(2020) 80–94.
54. [54]
  D. Liu, A. Angelova, J. Liu, et al., J. Mater. Chem. B 7(2019) 4706–4716. doi: 10.1039/C9TB00629J
55. [55]
  R.W. Taylor, D.M. Turnbull, Nat. Rev. Genet. 6(2005) 389–402. doi: 10.1038/nrg1606
56. [56]
  C.S. Burke, A. Byrne, T.E. Keyes, Angew. Chem. Int. Ed. 57(2018) 12420–12424. doi: 10.1002/anie.201806002
57. [57]
  P.F. Chinnery, G. Hudson, Br. Med. Bull. 106(2013) 135–159. doi: 10.1093/bmb/ldt017
58. [58]
  A.W. El-Hattab, W.J. Craigen, F. Scaglia, Biochim. Biophys. Acta Mol. Basis Dis. 1863(2017) 1539–1555. doi: 10.1016/j.bbadis.2017.02.017
59. [59]
  A. Klimpel, I. Neundorf, J. Control. Release 291(2018) 147–156. doi: 10.1016/j.jconrel.2018.10.029
60. [60]
  H. Li, W. Xu, F. Li, et al., Drug Deliv. 29(2022) 192–202. doi: 10.1080/10717544.2021.2023697
61. [61]
  M. Kleih, K. Bopple, M. Dong, et al., Cell Death Dis. 10(2019) 851–863. doi: 10.1038/s41419-019-2081-4
62. [62]
  G. Calmettes, B. Ribalet, S. John, et al., J. Mol. Cell Cardiol. 78(2015) 107–115. doi: 10.1016/j.yjmcc.2014.09.020
63. [63]
  G.S. Krasnov, A.A. Dmitriev, V.A. Lakunina, A.A. Kirpiy, A.V. Kudryavtseva, Expert Opin. Ther. Targets 17(2013) 1221–1233. doi: 10.1517/14728222.2013.833607
64. [64]
  S.P. Mathupala, Y.H. Ko, P.L. Pedersen, Oncogene 25(2006) 4777–4786. doi: 10.1038/sj.onc.1209603
65. [65]
  J.G. Pastorino, J.B. Hoek, Curr. Med. Chem. 10(2003) 1535–1551. doi: 10.2174/0929867033457269
66. [66]
  J.G. Pastorino, J.B. Hoek, J. Bioenerg. Biomembr. 40(2008) 171–182. doi: 10.1007/s10863-008-9148-8
67. [67]
  S. Reina, V. De Pinto, Curr. Med. Chem. 24(2017) 4447–4469.
68. [68]
  V. Shoshan-Barmatz, D. Ben-Hail, L. Admoni, Y. Krelin, S.S. Tripathi, Biochim. Biophys. Acta 1848(2015) 2547–2575. doi: 10.1016/j.bbamem.2014.10.040
69. [69]
  R.J. Winquist, V.K. Gribkoff, Biochem. Pharmacol. 177(2020) 113995. doi: 10.1016/j.bcp.2020.113995
70. [70]
  A. Magri, A. Messina, Curr. Med. Chem. 24(2017) 4470–4487.
71. [71]
  A.G. Assanhou, W. Li, L. Zhang, et al., Biomaterials 73(2015) 284–295. doi: 10.1016/j.biomaterials.2015.09.022
72. [72]
  Y. Liu, X. Zhang, M. Zhou, et al., ACS Appl. Mater. Interfaces 9(2017) 43498–43507. doi: 10.1021/acsami.7b14577
73. [73]
  S. Zhang, A. Long, A.J. Link, ACS Synth. Biol. 1(2012) 89–98. doi: 10.1021/sb200002m
74. [74]
  T.O. Jose-Luis Diaz, W. Horne, M. McConnell, et al., J. Biol. Chem. 17(1997) 11350–11355.
75. [75]
  F. Llambi, D.R. Green, Curr. Opin. Genet. Dev. 21(2011) 12–20. doi: 10.1016/j.gde.2010.12.001
76. [76]
  A. Shteinfer-Kuzmine, Z. Amsalem, T. Arif, A. Zooravlov, V. Shoshan-Barmatz, Mol. Oncol. 12(2018) 1077–1103. doi: 10.1002/1878-0261.12313
77. [77]
  M. Li, Y. Song, N. Song, et al., Nano. Lett. 21(2021) 5730–5737. doi: 10.1021/acs.nanolett.1c01469
78. [78]
  M.T. Jeena, L. Palanikumar, E.M. Go, et al., Nat. Commun. 8(2017) 26. doi: 10.1038/s41467-017-00047-z
79. [79]
  S. Kim, H.Y. Nam, J. Lee, J. Seo, Biochemistry 59(2020) 270–284. doi: 10.1021/acs.biochem.9b00857
80. [80]
  R. Lin, P. Zhang, A.G. Cheetham, et al., Bioconjug. Chem. 26(2015) 71–77. doi: 10.1021/bc500408p
81. [81]
  A.D. Woldetsadik, M.C. Vogel, W.M. Rabeh, M. Magzoub, FASEB J. 31(2017) 2168–2184. doi: 10.1096/fj.201601173R
82. [82]
  Q. Li, J. Yang, C. Chen, et al., J. Control. Release 325(2020) 38–51. doi: 10.1016/j.jconrel.2020.06.010
83. [83]
  A. Liu, X. Hou, Y. Ding, Y., Acta Pharm. Sin. 52(2017) 879–887.
84. [84]
  V. Gogvadze, S. Orrenius, B. Zhivotovsky, Biochim. Biophys. Acta 1757(2006) 639–647. doi: 10.1016/j.bbabio.2006.03.016
85. [85]
  H.Y. Chiu, E.X.Y. Tay, D.S.T. Ong, R. Taneja, Antioxid. Redox Signal. 32(2020) 309–330. doi: 10.1089/ars.2019.7898
86. [86]
  J. Wu, J. Li, H. Wang, C.B. Liu, Expert Opin. Drug Deliv. 15(2018) 951–964. doi: 10.1080/17425247.2018.1517750
87. [87]
  K.L. Horton, K.M. Stewart, S.B. Fonseca, Q. Guo, S.O. Kelley, Chem. Biol. 15(2008) 375–382. doi: 10.1016/j.chembiol.2008.03.015
88. [88]
  T. Zhao, X. Liu, S. Singh, et al., Bioconjug. Chem. 30(2019) 2312–2316. doi: 10.1021/acs.bioconjchem.9b00465
89. [89]
  Y. Deng, F. Jia, X. Chen, Q. Jin, J. Ji, Small 16(2020) e2001747. doi: 10.1002/smll.202001747
90. [90]
  J. Yang, Q. Li, M. Zhou, et al., Int. J. Pharm. 608(2021) 121077. doi: 10.1016/j.ijpharm.2021.121077
91. [91]
  P.P. Czupiel, V. Delplace, M.S. Shoichet, J. Control. Release 305(2019) 210–219. doi: 10.1016/j.jconrel.2019.04.045
92. [92]
  M. Abbas, Q. Zou, S. Li, X. Yan, Adv. Mater. 29(2017) 1605021. doi: 10.1002/adma.201605021
93. [93]
  Z.H. Wang, L. Chen, W. Li, L. Chen, Y.P. Wang, Mitochondrion 65(2022) 80–87. doi: 10.1016/j.mito.2022.05.002
94. [94]
  Z. Zheng, P. Chen, M. Xie, et al., J. Am. Chem. Soc. 138(2016) 11128–11131. doi: 10.1021/jacs.6b06903
95. [95]
  J. Zhou, X. Du, C. Berciu, et al., Chem 1(2016) 246–263. doi: 10.1016/j.chempr.2016.07.003
96. [96]
  J. Zhou, X. Du, N. Yamagata, B. Xu, J. Am. Chem. Soc. 138(2016) 3813–3823. doi: 10.1021/jacs.5b13541
97. [97]
  Q. Yao, Z. Huang, D. Liu, J. Chen, Y. Gao, Adv. Mater. 31(2019) e1804814. doi: 10.1002/adma.201804814
98. [98]
  H. Wang, Z. Feng, Y. Wang, et al., J. Am. Chem. Soc. 138(2016) 16046–16055. doi: 10.1021/jacs.6b09783
99. [99]
  J. Wang, Q. Zhou, X. Li, D. Dutta, Z. Ge, A.C.S. Macro, Lett. 11(2022) 543–548.
100. [100]
  P. Zhu, X. Yan, Y. Su, Y. Yang, J. Li, Chemistry (Easton) 16(2010) 3176–3183.
101. [101]
  P.C. Saha, T. Bera, T. Chatterjee, et al., Bioconjug. Chem. 32(2021) 833–841. doi: 10.1021/acs.bioconjchem.1c00106
102. [102]
  D. Zhang, G.B. Qi, Y.X. Zhao, et al., Adv. Mater. 27(2015) 6125–6130. doi: 10.1002/adma.201502598
103. [103]
  X.H. Zhang, D.B. Cheng, L. Ji, et al., Nano. Lett. 20(2020) 1286–1295. doi: 10.1021/acs.nanolett.9b04752
104. [104]
  D.B. Cheng, X.H. Zhang, Y.J. Gao, et al., J. Am. Chem. Soc. 141(2019) 7235–7239. doi: 10.1021/jacs.8b07727
105. [105]
  X. Jin, H. Yang, Z. Mao, B. Wang, J. Colloid Interface Sci. 601(2021) 714–726. doi: 10.1016/j.jcis.2021.05.135
106. [106]
  L. Wu, B. Lin, H. Yang, et al., Acta Biomater. 86(2019) 363–372. doi: 10.1016/j.actbio.2019.01.026
107. [107]
  Z. Feng, H. Wang, F. Wang, et al., Cell Rep. Phys. Sci. 1(2020) 100085. doi: 10.1016/j.xcrp.2020.100085
108. [108]
  PEPAXTO Prescribing Information, U.S. FOOD & DRUG ADMINISTRATION, 2020, https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process [2022-06-17].
109. [109]
  LUTATHERA Prescribing Information, U.S. FOOD & DRUG ADMINISTRATION, 2020, https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process [2022-06-17].
110. [110]
  K. Fosgerau, T. Hoffmann, Drug Discov. Today 20(2015) 122–128. doi: 10.1016/j.drudis.2014.10.003
111. [111]
  Safety, Efficacy & Pharmacokinetics of Elamipretide, clinicaltrials. gov, 2020, http://clinicaltrials.gov/ct2/show/NCT03323749 [2022-06-17].
112. [112]
  Safety and Efficacy of Elamipretide Primary Mitochondrial Myopathy, clinicaltrials. gov, 2020, http://clinicaltrials.gov/ct2/show/NCT03323749 [2022-06-17].
1. [1]
  Kun-Heng Li , Hong-Yang Zhao , Dan-Dan Wang , Ming-Hui Qi , Zi-Jian Xu , Jia-Mi Li , Zhi-Li Zhang , Shi-Wen Huang . Mitochondria-targeted nano-AIEgens as a powerful inducer for evoking immunogenic cell death. Chinese Chemical Letters, 2024, 35(5): 108882-. doi: 10.1016/j.cclet.2023.108882
2. [2]
  Junjie Wang , Yan Wang , Zhengdong Li , Changqiang Xie , Musammir Khan , Xingzhou Peng , Fabiao Yu . Triphenylamine-AIEgens photoactive materials for cancer theranostics. Chinese Chemical Letters, 2024, 35(6): 108934-. doi: 10.1016/j.cclet.2023.108934
3. [3]
  Yuanyi Zhou , Ke Ma , Jinfeng Liu , Zirun Zheng , Bo Hu , Yu Meng , Zhizhong Li , Mingshan Zhu . Is reactive oxygen species the only way for cancer inhibition over single atom nanomedicine? Autophagy regulation also works. Chinese Chemical Letters, 2024, 35(6): 109056-. doi: 10.1016/j.cclet.2023.109056
4. [4]
  Qiang Li , Jiangbo Fan , Hongkai Mu , Lin Chen , Yongzhen Yang , Shiping Yu . Nucleus-targeting orange-emissive carbon dots delivery adriamycin for enhanced anti-liver cancer therapy. Chinese Chemical Letters, 2024, 35(6): 108947-. doi: 10.1016/j.cclet.2023.108947
5. [5]
  Jiaqi Huang , Renjiang Kong , Yanmei Li , Ni Yan , Yeyang Wu , Ziwen Qiu , Zhenming Lu , Xiaona Rao , Shiying Li , Hong Cheng . Feedback enhanced tumor targeting delivery of albumin-based nanomedicine to amplify photodynamic therapy by regulating AMPK signaling and inhibiting GSTs. Chinese Chemical Letters, 2024, 35(8): 109254-. doi: 10.1016/j.cclet.2023.109254
6. [6]
  Yang Liu , Yan Liu , Kaiyin Yang , Zhiruo Zhang , Wenbo Zhang , Bingyou Yang , Hua Li , Lixia Chen . A selective HK2 degrader suppresses SW480 cancer cell growth by degrading HK2. Chinese Chemical Letters, 2024, 35(8): 109264-. doi: 10.1016/j.cclet.2023.109264
7. [7]
  Boran Cheng , Lei Cao , Chen Li , Fang-Yi Huo , Qian-Fang Meng , Ganglin Tong , Xuan Wu , Lin-Lin Bu , Lang Rao , Shubin Wang . Fluorine-doped carbon quantum dots with deep-red emission for hypochlorite determination and cancer cell imaging. Chinese Chemical Letters, 2024, 35(6): 108969-. doi: 10.1016/j.cclet.2023.108969
8. [8]
  Jing Chen , Peisi Xie , Pengfei Wu , Yu He , Zian Lin , Zongwei Cai . MALDI coupled with laser-postionization and trapped ion mobility spectrometry contribute to the enhanced detection of lipids in cancer cell spheroids. Chinese Chemical Letters, 2024, 35(4): 108895-. doi: 10.1016/j.cclet.2023.108895
9. [9]
  Huijie An , Chen Yang , Zhihui Jiang , Junjie Yuan , Zhongming Qiu , Longhao Chen , Xin Chen , Mutu Huang , Linlang Huang , Hongju Lin , Biao Cheng , Hongjiang Liu , Zhiqiang Yu . Luminescence-activated Pt(Ⅳ) prodrug for in situ triggerable cancer therapy. Chinese Chemical Letters, 2024, 35(7): 109134-. doi: 10.1016/j.cclet.2023.109134
10. [10]
  Mengjuan Sun , Muye Zhou , Yifang Xiao , Hailei Tang , Jinhua Chen , Ruitao Zhang , Chunjiayu Li , Qi Ya , Qian Chen , Jiasheng Tu , Qiyue Wang , Chunmeng Sun . Reversibly size-switchable polyion complex micelles for antiangiogenic cancer therapy. Chinese Chemical Letters, 2024, 35(7): 109110-. doi: 10.1016/j.cclet.2023.109110
11. [11]
  Chen Li , Ziyuan Zhao , Shouyun Yu . Photoredox-catalyzed C-glycosylation of peptides with glycosyl bromides. Chinese Chemical Letters, 2024, 35(6): 109128-. doi: 10.1016/j.cclet.2023.109128
12. [12]
  Lixian Fu , Yiyun Tan , Yue Ding , Weixia Qing , Yong Wang . Water–soluble and polarity–sensitive near–infrared fluorescent probe for long–time specific cancer cell membranes imaging and C. Elegans label. Chinese Chemical Letters, 2024, 35(4): 108886-. doi: 10.1016/j.cclet.2023.108886
13. [13]
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18. [18]
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19. [19]
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20. [20]
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沈阳化工大学材料科学与工程学院沈阳 110142