Citation: Yuhan Sun, He Zhang, Guangzhao Lu, Huan Wang, Ying Lu, Li Fan. Mitochondria-targeted cancer therapy based on functional peptides[J]. Chinese Chemical Letters, ;2023, 34(5): 107817. doi: 10.1016/j.cclet.2022.107817 shu

Mitochondria-targeted cancer therapy based on functional peptides

Department of Pharmaceutical Sciences, School of Pharmacy, Naval Medical University, Shanghai 200433, China

acuace@163.com

fanli7062022@163.com

Received Date: 16 June 2022
Revised Date: 7 September 2022
Accepted Date: 9 September 2022
Available Online: 13 September 2022

Figures(3)

Mitochondria are critical for tumor growth and metastasis. A number of traditional antitumor drugs have poor water solubility and must penetrate multiple cellular barriers to reach the mitochondria. Because mitochondria have a unique transmembrane potential and an inner membrane with a low permeability, it is difficult for most drugs to enter mitochondria. In recent years, mitochondria-targeted delivery systems that use functional peptides to modify drugs have received increasing attention. Introducing functional peptides can change the original physicochemical properties of drugs and actively target mitochondria. Functional peptide-drug conjugates (PDCs, peptide-drug conjugates) can decompose and release drugs over time or due to certain stimuli in tumors. This preserves the biological activity of the drug while increasing intratumor uptake through the enhanced permeability and retention effect (EPR, the enhanced permeability and retention effect). In this review, we focus on the direction of cancer therapy and review the application of different functional peptides in the mitochondria-targeted tumor treatments reported in recent years.
- Peptides,
- Mitochondria,
- Cancer therapy,
- Targeting,
- Cell uptake
1. [1]
  A.J. Roger, S.A. Muñoz-Gómez, R. Kamikawa, Curr. Biol. 27(2017) R1177-R1192. doi: 10.1016/j.cub.2017.09.015
2. [2]
  P. Ning, W. Wang, M. Chen, Y. Feng, X. Meng, Chin. Chem. Lett. 28(2017) 1943–1951. doi: 10.1016/j.cclet.2017.09.026
3. [3]
  M.J. Devine, J.T. Kittler, Nat. Rev. Neurosci. 19(2018) 63–80.
4. [4]
  J. Döhla, E. Kuuluvainen, N. Gebert, et al., Nat. Cell Biol. 24(2022) 148–154. doi: 10.1038/s41556-021-00837-0
5. [5]
  G. Siasos, V. Tsigkou, M. Kosmopoulos, et al., Ann. Transl. Med. 6(2018) 256–278. doi: 10.21037/atm.2018.06.21
6. [6]
  S. Fulda, L. Galluzzi, G. Kroemer, Nat. Rev. Drug Discov. 9(2010) 447–464. doi: 10.1038/nrd3137
7. [7]
  T. Hu, Z. Qin, C. Shen, H.L. Gong, Z.Y. He, Front. Bioeng. Biotechnol. 9(2021) 786621. doi: 10.3389/fbioe.2021.786621
8. [8]
  P.J. Burke, Trends Cancer 3(2017) 857–870. doi: 10.1016/j.trecan.2017.10.006
9. [9]
  X.S. Hou, H.S. Wang, B.P. Mugaka, G.J. Yang, Y. Ding, Biomater. Sci. 6(2018) 2786–2797. doi: 10.1039/C8BM00673C
10. [10]
  Y. Huang, T. Wang, Q. Tan, et al., Int. J. Nanomed. 16(2021) 4117–4146. doi: 10.2147/IJN.S315368
11. [11]
  B. Kalyanaraman, G. Cheng, M. Hardy, et al., Redox Biol. 14(2018) 316–327. doi: 10.1016/j.redox.2017.09.020
12. [12]
  K. Klein, K. He, A.I. Younes, et al., Front. Immunol. 11(2020) 573326. doi: 10.3389/fimmu.2020.573326
13. [13]
  S. Missiroli, M. Perrone, I. Genovese, P. Pinton, C. Giorgi, eBioMedicine 59(2020) 102943. doi: 10.1016/j.ebiom.2020.102943
14. [14]
  P.E. Porporato, N. Filigheddu, J.M.B. Pedro, G. Kroemer, L. Galluzzi, Cell Res. 28(2018) 265–280. doi: 10.1038/cr.2017.155
15. [15]
  S. Srinivasan, M. Guha, A. Kashina, N.G. Avadhani, Biochim. Biophys. Acta Bioenerg. 1858(2017) 602–614. doi: 10.1016/j.bbabio.2017.01.004
16. [16]
  W.X. Zong, J.D. Rabinowitz, E. White, Mol. Cell 61(2016) 667–676. doi: 10.1016/j.molcel.2016.02.011
17. [17]
  M.T. Jeena, S. Kim, S. Jin, J.H. Ryu, Cancers 12(2019) 26–46. doi: 10.3390/cancers12010026
18. [18]
  H. Qi, Y. Xu, P. Hu, C. Yao, D. Yang, Chin. Chem. Lett. 33(2022) 1131–1140. doi: 10.1016/j.cclet.2021.09.026
19. [19]
  K.G. Roth, I. Mambetsariev, P. Kulkarni, R. Salgia, Trends Mol. Med. 26(2020) 119–134.
20. [20]
  Y. Sun, A. Zhan, S. Zhou, et al., Chin. Chem. Lett. 30(2019) 1435–1439. doi: 10.1016/j.cclet.2019.05.001
21. [21]
  Y. Gao, H. Tong, J. Li, et al., Front. Bioeng. Biotechnol. 9(2021) 720508. doi: 10.3389/fbioe.2021.720508
22. [22]
  Z. Ma, Y. Zhang, J. Zhang, et al., ACS Appl. Mater. Interfaces 12(2020) 39434–39443. doi: 10.1021/acsami.0c11469
23. [23]
  R.C. Scaduto Jr., L.W. Grotyohann, Biophys. J. 76(1999) 469–477. doi: 10.1016/S0006-3495(99)77214-0
24. [24]
  E.K. Lei, S.O. Kelley, J. Am. Chem. Soc. 139(2017) 9455–9458. doi: 10.1021/jacs.7b04415
25. [25]
  W. Mitchell, E.A. Ng, J.D. Tamucci, et al., J. Biol. Chem. 295(2020) 7452–7469. doi: 10.1074/jbc.RA119.012094
26. [26]
  H.H. Szeto, AAPS J. 8(2006) E277–E283. doi: 10.1007/BF02854898
27. [27]
  M.P. Murphy, R.C. Hartley, Nat. Rev. Drug Discov. 17(2018) 865–886. doi: 10.1038/nrd.2018.174
28. [28]
  J. Zielonka, J. Joseph, A. Sikora, et al., Chem. Rev. 117(2017) 10043–10120. doi: 10.1021/acs.chemrev.7b00042
29. [29]
  Y. Bae, M.K. Jung, S.J. Song, et al., Mitochondrion 37(2017) 27–40. doi: 10.1016/j.mito.2017.06.005
30. [30]
  C. Bailly, Biochem. Pharmacol. 186(2021) 114467. doi: 10.1016/j.bcp.2021.114467
31. [31]
  S. Hong, X. Zhang, R.J. Lake, et al., Chem. Sci. 11(2019) 713–720.
32. [32]
  M. Shi, J. Zhang, X. Li, et al., Int. J. Nanomed. 13(2018) 4209–4226. doi: 10.2147/IJN.S163858
33. [33]
  V. Weissig, M. Lozoya, N. Yu, G.G.M. D'Souza, Methods Mol. Biol. 2275(2021) 13–25.
34. [34]
  Y. Feng, G. Qin, S. Chang, et al., Int. J. Nanomed. 16(2021) 3073–3089. doi: 10.2147/IJN.S297716
35. [35]
  D.A. Kuznetsova, G.A. Gaynanova, L.A. Vasileva, et al., J. Mater. Chem. B 7(2019) 7351–7362. doi: 10.1039/C9TB01853K
36. [36]
  C. Yue, Y. Yang, J. Song, et al., Nanoscale 9(2017) 11103–11118. doi: 10.1039/C7NR02193C
37. [37]
  P. Ning, L. Huang, Y. Bao, et al., Bioconjug. Chem. 31(2020) 2719–2725. doi: 10.1021/acs.bioconjchem.0c00518
38. [38]
  O. Oladimeji, J. Akinyelu, M. Singh, J. Biomed. Nanotechnol. 16(2020) 853–866. doi: 10.1166/jbn.2020.2930
39. [39]
  W. Wang, J. Liu, W. Feng, et al., Biomater. Sci. 7(2019) 1052–1063. doi: 10.1039/C8BM01414K
40. [40]
  L. Luo, M. Wang, Y. Zhou, et al., Anal. Chem. 93(2021) 6715–6722. doi: 10.1021/acs.analchem.1c00176
41. [41]
  J. Yan, J. Chen, N. Zhang, et al., J. Mater. Chem. B 8(2020) 492–503. doi: 10.1039/C9TB02266J
42. [42]
  L.H. Dian, Y.J. Hu, J.Y. Lin, et al., Int. J. Nanomed. 13(2018) 719–731. doi: 10.2147/IJN.S150140
43. [43]
  Z. Fan, B. Jiang, D. Shi, et al., Int. J. Pharm. 594(2021) 120184. doi: 10.1016/j.ijpharm.2020.120184
44. [44]
  H. Wang, W. Shi, D. Zeng, et al., J. Nanobiotechnol. 19(2021) 152. doi: 10.1186/s12951-021-00895-4
45. [45]
  H. Wang, F. Zhang, H. Wen, et al., J. Nanobiotechnol. 18(2020) 8–27. doi: 10.1186/s12951-019-0562-3
46. [46]
  Y. Zhang, C. Zhang, J. Chen, et al., ACS Appl. Mater. Interfaces 9(2017) 25152–25163. doi: 10.1021/acsami.7b07219
47. [47]
  S. Tang, Z. Davoudi, G. Wang, et al., Chem. Soc. Rev. 50(2021) 12679–12701. doi: 10.1039/D1CS00029B
48. [48]
  J. Xu, W. Du, Y. Zhao, et al., Acta Pharm. Sin. B 12(2022) 2778–2789. doi: 10.1016/j.apsb.2022.03.001
49. [49]
  L. Huang, Z. Sun, Q. Shen, et al., Chin. Chem. Lett. 33(2022) 4146–4156. doi: 10.1016/j.cclet.2022.02.047
50. [50]
  Y. Wang, A.G. Cheetham, G. Angacian, et al., Adv. Drug Deliv. Rev. 110-111(2017) 112–126. doi: 10.1016/j.addr.2016.06.015
51. [51]
  N. Mehrotra, S. Kharbanda, H. Singh, Nanomedicine (Lond) 15(2020) 2201–2217. doi: 10.2217/nnm-2020-0220
52. [52]
  Z. Luo, Y. Gao, Z. Duan, Y. Yi, H. Wang, Front. Bioeng. Biotechnol. 9(2021) 782234. doi: 10.3389/fbioe.2021.782234
53. [53]
  X. Li, W. Zhang, Q. Cao, et al., Cell Death Discov. 6(2020) 80–94.
54. [54]
  D. Liu, A. Angelova, J. Liu, et al., J. Mater. Chem. B 7(2019) 4706–4716. doi: 10.1039/C9TB00629J
55. [55]
  R.W. Taylor, D.M. Turnbull, Nat. Rev. Genet. 6(2005) 389–402. doi: 10.1038/nrg1606
56. [56]
  C.S. Burke, A. Byrne, T.E. Keyes, Angew. Chem. Int. Ed. 57(2018) 12420–12424. doi: 10.1002/anie.201806002
57. [57]
  P.F. Chinnery, G. Hudson, Br. Med. Bull. 106(2013) 135–159. doi: 10.1093/bmb/ldt017
58. [58]
  A.W. El-Hattab, W.J. Craigen, F. Scaglia, Biochim. Biophys. Acta Mol. Basis Dis. 1863(2017) 1539–1555. doi: 10.1016/j.bbadis.2017.02.017
59. [59]
  A. Klimpel, I. Neundorf, J. Control. Release 291(2018) 147–156. doi: 10.1016/j.jconrel.2018.10.029
60. [60]
  H. Li, W. Xu, F. Li, et al., Drug Deliv. 29(2022) 192–202. doi: 10.1080/10717544.2021.2023697
61. [61]
  M. Kleih, K. Bopple, M. Dong, et al., Cell Death Dis. 10(2019) 851–863. doi: 10.1038/s41419-019-2081-4
62. [62]
  G. Calmettes, B. Ribalet, S. John, et al., J. Mol. Cell Cardiol. 78(2015) 107–115. doi: 10.1016/j.yjmcc.2014.09.020
63. [63]
  G.S. Krasnov, A.A. Dmitriev, V.A. Lakunina, A.A. Kirpiy, A.V. Kudryavtseva, Expert Opin. Ther. Targets 17(2013) 1221–1233. doi: 10.1517/14728222.2013.833607
64. [64]
  S.P. Mathupala, Y.H. Ko, P.L. Pedersen, Oncogene 25(2006) 4777–4786. doi: 10.1038/sj.onc.1209603
65. [65]
  J.G. Pastorino, J.B. Hoek, Curr. Med. Chem. 10(2003) 1535–1551. doi: 10.2174/0929867033457269
66. [66]
  J.G. Pastorino, J.B. Hoek, J. Bioenerg. Biomembr. 40(2008) 171–182. doi: 10.1007/s10863-008-9148-8
67. [67]
  S. Reina, V. De Pinto, Curr. Med. Chem. 24(2017) 4447–4469.
68. [68]
  V. Shoshan-Barmatz, D. Ben-Hail, L. Admoni, Y. Krelin, S.S. Tripathi, Biochim. Biophys. Acta 1848(2015) 2547–2575. doi: 10.1016/j.bbamem.2014.10.040
69. [69]
  R.J. Winquist, V.K. Gribkoff, Biochem. Pharmacol. 177(2020) 113995. doi: 10.1016/j.bcp.2020.113995
70. [70]
  A. Magri, A. Messina, Curr. Med. Chem. 24(2017) 4470–4487.
71. [71]
  A.G. Assanhou, W. Li, L. Zhang, et al., Biomaterials 73(2015) 284–295. doi: 10.1016/j.biomaterials.2015.09.022
72. [72]
  Y. Liu, X. Zhang, M. Zhou, et al., ACS Appl. Mater. Interfaces 9(2017) 43498–43507. doi: 10.1021/acsami.7b14577
73. [73]
  S. Zhang, A. Long, A.J. Link, ACS Synth. Biol. 1(2012) 89–98. doi: 10.1021/sb200002m
74. [74]
  T.O. Jose-Luis Diaz, W. Horne, M. McConnell, et al., J. Biol. Chem. 17(1997) 11350–11355.
75. [75]
  F. Llambi, D.R. Green, Curr. Opin. Genet. Dev. 21(2011) 12–20. doi: 10.1016/j.gde.2010.12.001
76. [76]
  A. Shteinfer-Kuzmine, Z. Amsalem, T. Arif, A. Zooravlov, V. Shoshan-Barmatz, Mol. Oncol. 12(2018) 1077–1103. doi: 10.1002/1878-0261.12313
77. [77]
  M. Li, Y. Song, N. Song, et al., Nano. Lett. 21(2021) 5730–5737. doi: 10.1021/acs.nanolett.1c01469
78. [78]
  M.T. Jeena, L. Palanikumar, E.M. Go, et al., Nat. Commun. 8(2017) 26. doi: 10.1038/s41467-017-00047-z
79. [79]
  S. Kim, H.Y. Nam, J. Lee, J. Seo, Biochemistry 59(2020) 270–284. doi: 10.1021/acs.biochem.9b00857
80. [80]
  R. Lin, P. Zhang, A.G. Cheetham, et al., Bioconjug. Chem. 26(2015) 71–77. doi: 10.1021/bc500408p
81. [81]
  A.D. Woldetsadik, M.C. Vogel, W.M. Rabeh, M. Magzoub, FASEB J. 31(2017) 2168–2184. doi: 10.1096/fj.201601173R
82. [82]
  Q. Li, J. Yang, C. Chen, et al., J. Control. Release 325(2020) 38–51. doi: 10.1016/j.jconrel.2020.06.010
83. [83]
  A. Liu, X. Hou, Y. Ding, Y., Acta Pharm. Sin. 52(2017) 879–887.
84. [84]
  V. Gogvadze, S. Orrenius, B. Zhivotovsky, Biochim. Biophys. Acta 1757(2006) 639–647. doi: 10.1016/j.bbabio.2006.03.016
85. [85]
  H.Y. Chiu, E.X.Y. Tay, D.S.T. Ong, R. Taneja, Antioxid. Redox Signal. 32(2020) 309–330. doi: 10.1089/ars.2019.7898
86. [86]
  J. Wu, J. Li, H. Wang, C.B. Liu, Expert Opin. Drug Deliv. 15(2018) 951–964. doi: 10.1080/17425247.2018.1517750
87. [87]
  K.L. Horton, K.M. Stewart, S.B. Fonseca, Q. Guo, S.O. Kelley, Chem. Biol. 15(2008) 375–382. doi: 10.1016/j.chembiol.2008.03.015
88. [88]
  T. Zhao, X. Liu, S. Singh, et al., Bioconjug. Chem. 30(2019) 2312–2316. doi: 10.1021/acs.bioconjchem.9b00465
89. [89]
  Y. Deng, F. Jia, X. Chen, Q. Jin, J. Ji, Small 16(2020) e2001747. doi: 10.1002/smll.202001747
90. [90]
  J. Yang, Q. Li, M. Zhou, et al., Int. J. Pharm. 608(2021) 121077. doi: 10.1016/j.ijpharm.2021.121077
91. [91]
  P.P. Czupiel, V. Delplace, M.S. Shoichet, J. Control. Release 305(2019) 210–219. doi: 10.1016/j.jconrel.2019.04.045
92. [92]
  M. Abbas, Q. Zou, S. Li, X. Yan, Adv. Mater. 29(2017) 1605021. doi: 10.1002/adma.201605021
93. [93]
  Z.H. Wang, L. Chen, W. Li, L. Chen, Y.P. Wang, Mitochondrion 65(2022) 80–87. doi: 10.1016/j.mito.2022.05.002
94. [94]
  Z. Zheng, P. Chen, M. Xie, et al., J. Am. Chem. Soc. 138(2016) 11128–11131. doi: 10.1021/jacs.6b06903
95. [95]
  J. Zhou, X. Du, C. Berciu, et al., Chem 1(2016) 246–263. doi: 10.1016/j.chempr.2016.07.003
96. [96]
  J. Zhou, X. Du, N. Yamagata, B. Xu, J. Am. Chem. Soc. 138(2016) 3813–3823. doi: 10.1021/jacs.5b13541
97. [97]
  Q. Yao, Z. Huang, D. Liu, J. Chen, Y. Gao, Adv. Mater. 31(2019) e1804814. doi: 10.1002/adma.201804814
98. [98]
  H. Wang, Z. Feng, Y. Wang, et al., J. Am. Chem. Soc. 138(2016) 16046–16055. doi: 10.1021/jacs.6b09783
99. [99]
  J. Wang, Q. Zhou, X. Li, D. Dutta, Z. Ge, A.C.S. Macro, Lett. 11(2022) 543–548.
100. [100]
  P. Zhu, X. Yan, Y. Su, Y. Yang, J. Li, Chemistry (Easton) 16(2010) 3176–3183.
101. [101]
  P.C. Saha, T. Bera, T. Chatterjee, et al., Bioconjug. Chem. 32(2021) 833–841. doi: 10.1021/acs.bioconjchem.1c00106
102. [102]
  D. Zhang, G.B. Qi, Y.X. Zhao, et al., Adv. Mater. 27(2015) 6125–6130. doi: 10.1002/adma.201502598
103. [103]
  X.H. Zhang, D.B. Cheng, L. Ji, et al., Nano. Lett. 20(2020) 1286–1295. doi: 10.1021/acs.nanolett.9b04752
104. [104]
  D.B. Cheng, X.H. Zhang, Y.J. Gao, et al., J. Am. Chem. Soc. 141(2019) 7235–7239. doi: 10.1021/jacs.8b07727
105. [105]
  X. Jin, H. Yang, Z. Mao, B. Wang, J. Colloid Interface Sci. 601(2021) 714–726. doi: 10.1016/j.jcis.2021.05.135
106. [106]
  L. Wu, B. Lin, H. Yang, et al., Acta Biomater. 86(2019) 363–372. doi: 10.1016/j.actbio.2019.01.026
107. [107]
  Z. Feng, H. Wang, F. Wang, et al., Cell Rep. Phys. Sci. 1(2020) 100085. doi: 10.1016/j.xcrp.2020.100085
108. [108]
  PEPAXTO Prescribing Information, U.S. FOOD & DRUG ADMINISTRATION, 2020, https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process [2022-06-17].
109. [109]
  LUTATHERA Prescribing Information, U.S. FOOD & DRUG ADMINISTRATION, 2020, https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process [2022-06-17].
110. [110]
  K. Fosgerau, T. Hoffmann, Drug Discov. Today 20(2015) 122–128. doi: 10.1016/j.drudis.2014.10.003
111. [111]
  Safety, Efficacy & Pharmacokinetics of Elamipretide, clinicaltrials. gov, 2020, http://clinicaltrials.gov/ct2/show/NCT03323749 [2022-06-17].
112. [112]
  Safety and Efficacy of Elamipretide Primary Mitochondrial Myopathy, clinicaltrials. gov, 2020, http://clinicaltrials.gov/ct2/show/NCT03323749 [2022-06-17].
1. [1]
  Yong Dai , Bao-Kuo Lv , Xin-Fu Zhang , Yi Xiao . A two-photon mitotracker based on a naphthalimide fl uorophore：Synthesis, photophysical properties and cell imaging. Chinese Chemical Letters, 2014, 25(7): 1001-1005. doi: 10.1016/j.cclet.2014.05.020
2. [2]
  Yasuya Kudo , Kazunori Koiwai , Kazuhiro Shimizu , Shota Kusuki , Mina Sakuragi , Naohiko Shimada , Yoichi Takeda , Kazuo Sakurai . Amidine-bearing lipoplex targeting to hepatocyte cells. Chinese Chemical Letters, 2008, 19(9): 1115-1118. doi: 10.1016/j.cclet.2008.06.001
3. [3]
  Qing Lin Jiang , Li Hai , Lei Chen , Jiao Lu , Zhi Rong Zhang , Yong Wu . Synthesis of a novel multivalent galactoside with high hepatocyte targeting for gene delivery. Chinese Chemical Letters, 2008, 19(2): 127-129. doi: 10.1016/j.cclet.2007.12.002
4. [4]
  Zheng Pan , Liu Yang , Chen Jinjin , Xu Weiguo , Li Gao , Ding Jianxun . Targeted pH-responsive polyion complex micelle for controlled intracellular drug delivery. Chinese Chemical Letters, 2020, 31(5): 1178-1182. doi: 10.1016/j.cclet.2019.12.001
5. [5]
  Yang Limin , Gao Peng , Huang Yuanlei , Lu Xiao , Chang Qian , Pan Wei , Li Na , Tang Bo . Boosting the photodynamic therapy efficiency with a mitochondria-targeted nanophotosensitizer. Chinese Chemical Letters, 2019, 30(6): 1293-1296. doi: 10.1016/j.cclet.2019.03.032
6. [6]
  Shuang Chen , Yongzhuo Liu , Ri Liang , Gaobo Hong , Jing An , Xiaojun Peng , Wen-Heng Zheng , Fengling Song . Self-assembly of amphiphilic peptides to construct activatable nanophotosensitizers for theranostic photodynamic therapy. Chinese Chemical Letters, 2021, 32(12): 3903-3906. doi: 10.1016/j.cclet.2021.06.041
7. [7]
  Dachuan Qi , Lei Xing , Lijun Shen , Wenshuang Sun , Cheng Cai , Chunhua Xue , Xuwei Song , Hua Yu , Hulin Jiang , Chengjun Li , Qingri Jin , Zhiqi Zhang . A GSH-depleted platinum(Ⅳ) prodrug triggers ferroptotic cell death in breast cancer. Chinese Chemical Letters, 2022, 33(10): 4595-4599. doi: 10.1016/j.cclet.2022.03.105
8. [8]
  Jie Jiao , Qiang Wang , Hua Wei Zhu , Hao Fang , Wen Fang Xu . Synthesis and biological evaluation of a new series of histone deacetylases inhibitors. Chinese Chemical Letters, 2008, 19(6): 673-675. doi: 10.1016/j.cclet.2008.04.010
9. [9]
  Cui Jingjing , Yao Yuhua , Chen Cong , Huang Rui , Zhang Weibing , Qian Junhong . Mitochondria-targeted ratiometric fluorescent probes for micropolarity and microviscosity and their applications. Chinese Chemical Letters, 2019, 30(5): 1071-1074. doi: 10.1016/j.cclet.2018.12.031
10. [10]
  Zhao Jiaoyan , Jiang Xuefeng . The application of sulfur-containing peptides in drug discovery. Chinese Chemical Letters, 2018, 29(7): 1079-1087. doi: 10.1016/j.cclet.2018.05.026
11. [11]
  Sun Xiu-Xia , Fan Jun , Hou Yan-Nan , Liang Shuo , Zhang Yu-Ping , Xiao Jian-Xi . Fluorescence characterization of the thermal stability of collagen mimic peptides. Chinese Chemical Letters, 2017, 28(5): 963-967. doi: 10.1016/j.cclet.2016.11.029
12. [12]
  Ning Peng , Wang Wenjuan , Chen Man , Feng Yan , Meng Xiangming . Recent advances in mitochondria-and lysosomes-targeted small-molecule two-photon fluorescent probes. Chinese Chemical Letters, 2017, 28(10): 1943-1951. doi: 10.1016/j.cclet.2017.09.026
13. [13]
  Hangqi Zhu , Bing Zhang , Nali Zhu , Mingchun Li , Qilin Yu . Mitochondrion targeting peptide-modified magnetic graphene oxide delivering mitoxantrone for impairment of tumor mitochondrial functions. Chinese Chemical Letters, 2021, 32(3): 1220-1223. doi: 10.1016/j.cclet.2020.09.003
14. [14]
  Chen Yaqi , Liang Jingjing , Li Tao , Lin Ping , Zhao Yibing , Wu Chuanliu . Interchain doubly-bridged α-helical peptides for the development of protein binders. Chinese Chemical Letters, 2019, 30(4): 924-928. doi: 10.1016/j.cclet.2019.02.013
15. [15]
  Yishen Mao , Caifeng Zou , Yongjian Jiang , Deliang Fu . Erythrocyte-derived drug delivery systems in cancer therapy. Chinese Chemical Letters, 2021, 32(3): 990-998. doi: 10.1016/j.cclet.2020.08.048
16. [16]
  Hedong Qi , Yuwei Xu , Pin Hu , Chi Yao , Dayong Yang . Construction and applications of DNA-based nanomaterials in cancer therapy. Chinese Chemical Letters, 2022, 33(3): 1131-1140. doi: 10.1016/j.cclet.2021.09.026
17. [17]
  Fanwen Sun , Yayun Peng , Yanping Li , Menghan Xu , Ting Cai . Fenton-reaction-triggered metabolism of acetaminophen for enhanced cancer therapy. Chinese Chemical Letters, 2023, 34(2): 107507-1-107507-6. doi: 10.1016/j.cclet.2022.05.021
18. [18]
  Tianqi Wang , Yanan Fu , Shengjie Sun , Chenyi Huang , Yunfei Yi , Junqing Wang , Yang Deng , Meiying Wu . Exosome-based drug delivery systems in cancer therapy. Chinese Chemical Letters, 2023, 34(2): 107508-1-107508-8. doi: 10.1016/j.cclet.2022.05.022
19. [19]
  Dai Lingzi , Guo Nian , Liu Yaqin , Shen Shanshan , Ge Qiufu , Pan Yuanjiang . Analysis of the binding sites with NL-101 to amino acids and peptides by HPLC/MS/MS. Chinese Chemical Letters, 2019, 30(1): 103-106. doi: 10.1016/j.cclet.2017.12.023
20. [20]
  Wang Yuzhen , Song Yujun , Zhu Guixian , Zhang Dechen , Liu Xuewu . Highly biocompatible BSA-MnO₂ nanoparticles as an efficient near-infrared photothermal agent for cancer therapy. Chinese Chemical Letters, 2018, 29(11): 1685-1688. doi: 10.1016/j.cclet.2017.12.004

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沈阳化工大学材料科学与工程学院沈阳 110142