Citation: Shuyi Wang, Zizhen Zhao, Jiayang Yao, Siyang Jiang, Zhan-Ting Li, Da Ma. Reactive oxygen specie-induced photodynamic therapy activation by supramolecular strategy[J]. Chinese Chemical Letters, ;2023, 34(5): 107805. doi: 10.1016/j.cclet.2022.107805 shu

Reactive oxygen specie-induced photodynamic therapy activation by supramolecular strategy

Shuyi Wang ^{a, b} ,
Zizhen Zhao ^a ,
Jiayang Yao ^c ,
Siyang Jiang ^a ,
Zhan-Ting Li ^{a, *,} ,
Da Ma ^{b, *,}

a.
Department of Chemistry, Fudan University, Shanghai 200438, China
b.
School of Pharmaceutical Engineering and Institute for Advanced Studies, Taizhou University, Taizhou 318000, China
c.
Department of Mechanics and Engineering Science, College of Engineering, Peking University, Beijing 100871, China

ztli@fudan.edu.cn

dama@fudan.edu.cn

Received Date: 4 July 2022
Revised Date: 30 August 2022
Accepted Date: 2 September 2022
Available Online: 6 September 2022

Figures(4)

Photodynamic therapy (PDT) agents may accumulate in skin and cause severe skin cytotoxicity. We report a pro-guest-based supramolecular strategy to selectively activate PDT in the reactive oxygen specie (ROS) overexpressed microenvironment, which is often existing in tumor and inflammatory tissues. PDT agents methylene blue (MB) and basic blue 17 (BB17) are used as model drugs. When encapsulated by acyclic cucurbit[n]uril (CB[n]), the efficacy of PDT agents is significantly inhibited. By contrast, in the presence of ROS (H₂O₂) and pro-guest, PDT agents are displaced and reactivated to show a dramatically enhanced PDT efficacy in cells.
- Photodynamic therapy,
- Host-guest chemistry,
- Cucurbit[n]uril,
- Reactive oxygen specie
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