Citation: Lu Tang, Mengying Xie, Jing Li, Yijun Mei, Yuqi Cao, Qiaqia Xiao, Haijuan Dong, Yuhui Zhang, Wei Wang. Leveraging nano-engineered mesenchymal stem cells for intramedullary spinal cord tumor treatment[J]. Chinese Chemical Letters, ;2023, 34(5): 107801. doi: 10.1016/j.cclet.2022.107801 shu

Leveraging nano-engineered mesenchymal stem cells for intramedullary spinal cord tumor treatment

Lu Tang ^{a, b, 1} ,
Mengying Xie ^{a, b, 1} ,
Jing Li ^{a, b} ,
Yijun Mei ^{a, b} ,
Yuqi Cao ^{a, b} ,
Qiaqia Xiao ^{a, b} ,
Haijuan Dong ^c ,
Yuhui Zhang ^{d, *,} ,
Wei Wang ^{a, b, **,}

a.
Department of Pharmaceutics, State Key Laboratory of Natural Medicines, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
b.
NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients, China Pharmaceutical University, Nanjing 210009, China
c.
The Public Laboratory Platform, China Pharmaceutical University, Nanjing 210009, China
d.
Department of Spine Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China

^**

yuhuizhang_2003@126.com

wangcpu209@cpu.edu.cn

Received Date: 3 May 2022
Revised Date: 20 August 2022
Accepted Date: 2 September 2022
Available Online: 6 September 2022

Figures(5)

Intramedullary spinal cord tumor (IMSCT) is comparatively rare malignant tumor in the central nervous system and is very difficult accessible by conventional chemotherapy regimen. Currently, there are very limited researches for IMSCT treatment using nanomedicine. To fill this gap, we originally reported a targeted strategy by leveraging nano-engineered mesenchymal stem cells (MSCs) for synergistic anti-IMSCT treatment. In this study, two mode drugs paclitaxel (PTX) and metformin (MET) were co-loaded in maleimide-modified poly(lactic-co-glycolicacid) (PLGA-MAL) nanoparticles, which were further conjugated onto MSCs surface via the thioether bond formed between PLGA-MAL and MSCs without affecting the migration ability of MSCs. Owing to the excellent tumor tropism and penetrability of MSCs and good biodegradability of PLGA, the designed drug delivery platform could accurately target IMSCT sites to exert long-term synergistic antitumor efficacy, exhibiting promising research value for alternative IMSCT management beyond surgery.
- Mesenchymal stem cell,
- Intramedullary spinal cord tumor,
- Metformin,
- Nanosystem,
- Targeted drug delivery
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