Citation: Qijun Du, Jian Zou, Zhongbing Huang, Shimei Li, Longfei Tan, Xiangling Ren, Guangfu Yin, Yongfa Zheng, Xianwei Meng. Fabrication of microwave-sensitized nanospheres of covalent organic framework with apatinib for tumor therapy[J]. Chinese Chemical Letters, ;2023, 34(5): 107763. doi: 10.1016/j.cclet.2022.107763 shu

Fabrication of microwave-sensitized nanospheres of covalent organic framework with apatinib for tumor therapy

Qijun Du ^{a, c, 1} ,
Jian Zou ^{a, 1} ,
Zhongbing Huang ^{a, *,} ,
Shimei Li ^a ,
Longfei Tan ^b ,
Xiangling Ren ^b ,
Guangfu Yin ^a ,
Yongfa Zheng ^{d, *,} ,
Xianwei Meng ^{b, *,}

a.
College of Biomedical Engineering, Sichuan University, Chengdu 610065, China
b.
Laboratory of Controllable Preparation and Application of Nanomaterials, CAS Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China
c.
Sichuan Kangcheng Biotechnology Co., Ltd., Chengdu 610041, China
d.
Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430060, China

195773820@qq.com

zbhuang@scu.edu.cn

zyftgwz1986@163.com

mengxw@mail.ipc.ac.cn

Received Date: 3 April 2022
Revised Date: 16 August 2022
Accepted Date: 17 August 2022
Available Online: 20 August 2022

Figures(4)

A new nanocomposite of hollow covalent organic framework (COF) conjugated with the apatinib (AP) and loading microwave-sensitizer (ionic liquid, IL) was prepared by layer by layer (LBL) method and hyaluronic acid (HA) coating, named as COF-AP-IL@HA. AP loading rate in COF hollow-spheres (~30 nm shell thickness) was ~40.3%, due to the interactions of hydrogen and π-π bonds between AP and COF shell, and acidic environment destroyed COF structure, promoting AP release. Microwave sensitization of loaded IL in COF hollow-spheres could enhance the microwave heat-effect, and combined AP therapeutic ability, leading to their higher inhibitation on tumor, due to targeting ability of HA and the local release of apatinib. 88.9% of inhibition rate of COF-AP-IL@HA under microwave on the in vivo tumor was significantly higher than those without microwave (12.3%) and COF-IL@HA with microwave (37.5%), indicating a synergism of sensitized microwave hyperthermia and AP therapy on the reduced expression of VEGF via the downregulation pathway of hypoxia inducible factor. These results indicated that COF-AP-IL@HA was potential to the application in the combination therapy of tumor of the sensitized microwave hyperthermia and apatinib.
- Covalent organic framework,
- Antiangiogenesis,
- Tumor therapy,
- Microwave hyperthermia,
- Hollow spheres
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