Citation: Ming Chen, Ying Xie, Qian Luo, Jiarui Xu, Yuxin Ren, Rui Liu, Huihui Zhao, Yuling Chen, Hexuan Feng, Yafei Du, Jianwei Li, Guiling Wang, Wanliang Lu. Switchable nanoparticles complexing cisplatin for circumventing glutathione depletion in breast cancer chemotherapy[J]. Chinese Chemical Letters, ;2023, 34(5): 107744. doi: 10.1016/j.cclet.2022.107744 shu

Switchable nanoparticles complexing cisplatin for circumventing glutathione depletion in breast cancer chemotherapy

State Key Laboratory of Natural and Biomimetic Drugs, Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery Systems, and School of Pharmaceutical Sciences, Peking University, Beijing 100191, China

luwl@bjmu.edu.cn

Received Date: 6 May 2022
Revised Date: 8 August 2022
Accepted Date: 10 August 2022
Available Online: 14 August 2022

Figures(4)

Cisplatin is broad-spectrum chemotherapeutic agent that has been widely used for the treatment of a variety of malignant tumors including breast cancer. However, the cisplatin chemoresistance, which derives from the inactivation by glutathione (GSH) depletion, remains a scientific issue to solve. Here, we report a novel type of smart disulfide switchable nanoparticles complexing cisplatin (switch NPs-cisplatin) that is rationally designed, and engineered by synthesizing a hyaluronic acid disulfide bonded polyaspartic acid (HA-ss-Pasp) and complexing cisplatin. The results showed that the switch NPs-cisplatin had a nanoscale of particle size (150 nm), higher drug encapsulation efficiency (> 90%), and suitable drug release profile. They demonstrated evident pH responsiveness and GSH responsiveness, and targeting effect in the resistant breast cancer cells. Furthermore, they were able to block the cisplatin depletion by GSH in the resistant cancer cells, thereby circumventing the chemoresistance. Consequently, switch NPs-cisplatin displayed a remarkable killing effect in the resistant breast cancer cells in vitro, and in the resistant breast cancer-bearing mice. In conclusion, switch NPs-cisplatin could be used as a smart formulation of cisplatin for overcoming the chemoresistance of breast cancer. The present study also offers a universal drug delivery carrier platform for highly efficient but low systemic toxic chemotherapy.
- Disulfide switchable nanoparticles,
- pH responsiveness,
- GSH depletion,
- Cisplatin chemoresistance,
- Breast cancer
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