Citation: Guiting Liu, Yuan Zhou, Zejun Xu, Ziting Bao, Li Zheng, Jun Wu. Janus hydrogel with dual antibacterial and angiogenesis functions for enhanced diabetic wound healing[J]. Chinese Chemical Letters, ;2023, 34(4): 107705. doi: 10.1016/j.cclet.2022.07.048 shu

Janus hydrogel with dual antibacterial and angiogenesis functions for enhanced diabetic wound healing

Guiting Liu ^{a, 1} ,
Yuan Zhou ^{a, 1} ,
Zejun Xu ^c ,
Ziting Bao ^c ,
Li Zheng ^{d, e, *,} ,
Jun Wu ^{b, c, *,}

a.
The State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute of Sichuan University, Chengdu 610065, China
b.
Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital Sun Yat-sen University, Guangzhou 510120, China
c.
School of Biomedical Engineering, Sun Yat-sen University, Guangzhou 510006, China
d.
Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, Life Science Institutes, Guangxi Medical University, Nanning 530021, China
e.
Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry, Guangxi Medical University, Nanning 530021, China

zhengli224@163.com

wujun29@mail.sysu.edu.cn

Received Date: 29 April 2022
Revised Date: 18 July 2022
Accepted Date: 21 July 2022
Available Online: 23 July 2022

Figures(4)

Anti-infection and neovascularization at the wound site are two vital factors that accelerate diabetic wound healing. However, for a wound healing dressing, the two functions need to work at different sites (inner and outer), giving big challenges for dressing design. In this study, we fabricated a novel sodium alginate/chitosan (SA/CS) Janus hydrogel dressing by the assembly of SA hydrogel loaded with silver nanoparticles (AgNPs) and CS hydrogel impregnated with l-arginine loaded sodium alginate microspheres (ArgMSs) based on electrostatic interactions to combine the two functions. The outer SA-AgNP hydrogel could prevent infection while avoiding the deposition of AgNPs in the wound site, and the inner CS-ArgMS hydrogel on the wound surface could realize the sustained release of l-arginine and promote vascular regeneration. The composition, morphology and swelling/degradation of the SA-AgNP/CS-ArgMS hydrogel were characterized systematically. l-Arginine release behavior has been tested and SA-AgNP/CS-ArgMS hydrogel has been confirmed for excellent biocompatibility. Antibacterial and angiogenesis assays demonstrated the antibacterial and angiogenesis characteristics of the SA-AgNP/CS-ArgMS hydrogel. Finally, in vivo diabetic wound healing assay demonstrated that the SA-AgNP/CS-ArgMS hydrogel could significantly accelerate re-epithelialization, granulation tissue formation, collagen deposition and angiogenesis, thereby resulting in enhanced diabetic wound healing
- Janus hydrogel,
- Antibacterial,
- Angiogenesis,
- Diabetic wound,
- Wound healing
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