Citation: Hailing Zhao, Nan Li, Caixia Ma, Zhengwei Wei, Qiya Zeng, Keyi Zhang, Na Zhao, Ben Zhong Tang. An AIE probe for long-term plasma membrane imaging and membrane-targeted photodynamic therapy[J]. Chinese Chemical Letters, ;2023, 34(4): 107699. doi: 10.1016/j.cclet.2022.07.042 shu

An AIE probe for long-term plasma membrane imaging and membrane-targeted photodynamic therapy

Hailing Zhao ^a ,
Nan Li ^a ,
Caixia Ma ^a ,
Zhengwei Wei ^a ,
Qiya Zeng ^a ,
Keyi Zhang ^a ,
Na Zhao ^{a, *,} ,
Ben Zhong Tang ^b

a.
Key Laboratory of Macromolecular Science of Shaanxi Province, Key Laboratory of Applied Surface and Colloid Chemistry of Ministry of Education, and School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi'an 710119, China
b.
School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen 518172, China

nzhao@snnu.edu.cn

Received Date: 5 May 2022
Revised Date: 19 July 2022
Accepted Date: 21 July 2022
Available Online: 23 July 2022

Figures(6)

Two red-emissive luminogens (TPTH and TPTB) with typical aggregation-induced emission characteristics were developed. By introducing the heavy atom of Br at the end of alkyl chain, TPTB exhibited higher reactive oxygen species generation efficiency through both types Ⅰ and Ⅱ pathways. Due to its excellent biocompatibility and proper lipophilicity, TPTB could be used for long-term cell membrane staining and this staining ability was independent of the change of plasma membrane potential. Furthermore, TPTB could ablate the cancer cells through cell membrane-targeted photodynamic therapy.
- Aggregation-induced emission,
- Plasma membrane,
- Fluorescent probe,
- Long-term imaging,
- Photodynamic therapy
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