Citation: Shuangling Luo, Chao Liang, Qianling Zhang, Pingyu Zhang. Iridium photosensitizer constructed liposomes with hypoxia-activated prodrug to destrust hepatocellular carcinoma[J]. Chinese Chemical Letters, ;2023, 34(4): 107666. doi: 10.1016/j.cclet.2022.07.009 shu

Iridium photosensitizer constructed liposomes with hypoxia-activated prodrug to destrust hepatocellular carcinoma

College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, China

p.zhang6@szu.edu.cn

Received Date: 16 April 2022
Revised Date: 1 July 2022
Accepted Date: 7 July 2022
Available Online: 9 July 2022

Figures(5)

Hypoxic tumor microenvironment is a major challenge for photodynamic therapy (PDT). To overcome this problem, PDT combined hypoxia-activated chemotherapy is a promising strategy for hypoxic cancer therapy. Herein, a multifunctional liposome (AQ4N-Ir1-sorafenib-liposome) is prepared by encapsulating a hypoxia-activated prodrug AQ4N, a photosensitizer iridium(Ⅲ) complex and hepatocellular carcinoma (HCC) targeting drug sorafenib, for synergistic therapy of HCC. Ir1-mediated PDT upon irradiation induces ROS generation and hypoxic environment, which leads to the disassembly of the liposome and activates the antitumor activity of AQ4N. Meantime, the co-delivered sorafenib could effectively target therapy of HCC. It is noted that ferroptosis mechanism is proved during the treatment. This work contributes to the design of hypoxia-responsive multifunctional liposome for combination of chemotherapy, targeting therapy and PDT. It is a promising strategy for hypoxic HCC therapy.
- Hypoxia activation,
- Iridium photosensitizer,
- Ferroptosis,
- Photodynamic therapy,
- Chemotherapy
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