Citation: Yue Li, Nong Lu, Qitian Lin, Haobing Wang, Zhuoming Liang, Yujuan Lu, Pingyu Zhang. Sono-ReCORMs for synergetic sonodynamic-gas therapy of hypoxic tumor[J]. Chinese Chemical Letters, ;2023, 34(1): 107653. doi: 10.1016/j.cclet.2022.06.076 shu

Sono-ReCORMs for synergetic sonodynamic-gas therapy of hypoxic tumor

Yue Li ^a ,
Nong Lu ^a ,
Qitian Lin ^b ,
Haobing Wang ^a ,
Zhuoming Liang ^b ,
Yujuan Lu ^{a, *,} ,
Pingyu Zhang ^{a, *,}

a.
College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, China
b.
Whittle School and Studios Shenzhen Campus, Shenzhen 518066, China

yjlv@szu.edu.cn

p.zhang6@szu.edu.cn

Received Date: 11 February 2022
Revised Date: 26 June 2022
Accepted Date: 28 June 2022
Available Online: 30 June 2022

Figures(6)

Carbon monoxide (CO) gas therapy, a novel anti-tumor technique based on the cytotoxicity from the CO released in situ, has become one of the hot topics in cancer treatment. Since the technique is oxygen-independent, it displays promising therapeutic effect for hypoxic tumor where traditional photodynamic therapy shows limited efficacy and insufficient penetration depth. To fully address these limitations of PDT, we propose a synergetic sonodynamic-CO gas releasing strategy for the therapy of hypoxic tumor. In this work, two rhenium(I) tricarbonyl complexes with different substituted ligands are investigated for US-triggered ROS generation and CO release. Our results indicated that the electron-donating NMe₂-substituted complex (Re-NMe₂) exhibits stronger luminescence intensity and generates more singlet oxygen (¹O₂) than the electron-withdrawing NO₂-substituted complex (Re-NO₂). In addition, Re-NMe₂ displays release of CO triggered by US, thus showing high sono-cytotoxicity to tumor cells in-vitro and in-vivo. The strong ROS-generating capability combined with rapid CO-releasing feature from Re-NMe₂ has made it a powerful tool for the efficient treatment of hypoxic tumor.
- Synergetic sonodynamic-gas therapy,
- Carbon monoxide (CO),
- Rhenium(I) tricarbonyl complex,
- Hypoxic tumor
1. [1]
  C. Szabo, Nat. Rev. Drug Discov. 15 (2016) 185-203. doi: 10.1038/nrd.2015.1
2. [2]
  Y. Wang, T. Yang, Q. He, Natl. Sci. Rev. 7 (2020) 1485-1512. doi: 10.1093/nsr/nwaa034
3. [3]
  L. Chen, S.F. Zhou, L. Su, et al., ACS Nano 13 (2019) 10887-10917. doi: 10.1021/acsnano.9b04954
4. [4]
  C.C. Romão, W.A. Blättler, J.D. Seixas, et al., Chem. Soc. Rev. 41 (2012) 3571-3583. doi: 10.1039/c2cs15317c
5. [5]
  R. Motterlini, L.E. Otterbein, Nat. Rev. Drug Discov. 9 (2010) 728-743. doi: 10.1038/nrd3228
6. [6]
  H. Yan, J. Du, S. Zhu, et al., Small 15 (2019) 1904382. doi: 10.1002/smll.201904382
7. [7]
  K. Ling, F. Men, W.C. Wang, et al., J. Med. Chem. 61 (2018) 2611-2635. doi: 10.1021/acs.jmedchem.6b01153
8. [8]
  B. Wegiel, D. Gallo, E. Csizmadia, et al., Cancer Res. 73 (2013) 7009. doi: 10.1158/0008-5472.CAN-13-1075
9. [9]
  T. He, X. Qin, C. Jiang, et al., Theranostics 10 (2020) 2453-2462. doi: 10.7150/thno.42981
10. [10]
  P.C. Ford, Coord. Chem. Rev. 376 (2018) 548-564. doi: 10.1016/j.ccr.2018.07.018
11. [11]
  T. Slanina, P. Šebej, Photochem. Photobiol. Sci. 17 (2018) 692-710. doi: 10.1039/c8pp00096d
12. [12]
  Q. He, D.O. Kiesewetter, Y. Qu, et al., Adv. Mater. 27 (2015) 6741-6746. doi: 10.1002/adma.201502762
13. [13]
  Z. Jin, Y. Wen, L. Xiong, et al., Chem. Commun. 53 (2017) 5557-5560. doi: 10.1039/C7CC01576C
14. [14]
  B. Pauwels, C. Boydens, L. Vanden Daele, et al., J. Pharm. Pharmacol. 68 (2016) 293-304. doi: 10.1111/jphp.12511
15. [15]
  S. Geri, T. Krunclova, O. Janouskova, et al., Chem. Eur. J. 26 (2020) 10992-11006. doi: 10.1002/chem.202002139
16. [16]
  L.C.C. Lee, K.K. Leung, K.K.W. Lo, Dalton Trans. 46 (2017) 16357-16380. doi: 10.1039/C7DT03465B
17. [17]
  A.E. Pierri, A. Pallaoro, G. Wu, P.C. Ford, J. Am. Chem. Soc. 134 (2012) 18197-18200. doi: 10.1021/ja3084434
18. [18]
  S.C. Marker, S.N. MacMillan, W.R. Zipfel, et al., Inorg. Chem. 57 (2018) 1311-1331. doi: 10.1021/acs.inorgchem.7b02747
19. [19]
  C.V. Garcia, G.L. Parrilha, B.L. Rodrigues, et al., New J. Chem. 40 (2016) 7379-7387. doi: 10.1039/C6NJ00050A
20. [20]
  D. Lee, I.Y. Kim, S. Saha, et al., Pharmacol. Ther. 162 (2016) 120-133. doi: 10.1016/j.pharmthera.2016.01.003
21. [21]
  H. Inaba, K. Fujita, T. Ueno, Biomater. Sci. 3 (2015) 1423-1438. doi: 10.1039/C5BM00210A
22. [22]
  J. Chen, T. Fan, Z. Xie, et al., Biomaterials 237 (2020) 119827. doi: 10.1016/j.biomaterials.2020.119827
23. [23]
  C.F. Amantino, Á. de Baptista-Neto, A.C. Badino, et al., Photodiagn. Photodyn. Ther. 31 (2020) 101815. doi: 10.1016/j.pdpdt.2020.101815
24. [24]
  F. Jiang, C. Yang, B. Ding, et al., Chin. Chem. Lett. 33 (2022) 2959–2964. doi: 10.1016/j.cclet.2021.12.096
25. [25]
  C. Liang, J. Xie, S. Luo, et al., Nat. Commun. 12 (2021) 5001. doi: 10.1038/s41467-021-25303-1
26. [26]
  J. Xie, C. Liang, S. Luo, et al., ACS Appl. Mater. Interfaces 13 (2021) 27934-27944. doi: 10.1021/acsami.1c06381
27. [27]
  X. Xing, S. Zhao, T. Xu, et al., Coord. Chem. Rev. 445 (2021) 214087. doi: 10.1016/j.ccr.2021.214087
28. [28]
  Y. Zhang, X. Zhang, H. Yang, et al., Chem. Soc. Rev. 50 (2021) 11227-11248. doi: 10.1039/d1cs00403d
29. [29]
  H. Chen, L. Liu, A. Ma, et al., Biomaterials 269 (2021) 120639. doi: 10.1016/j.biomaterials.2020.120639
30. [30]
  Y. Yang, X. Wang, H. Qian, et al., Appl. Mater. Today 25 (2021) 101215. doi: 10.1016/j.apmt.2021.101215
31. [31]
  Z. Jin, P. Zhao, J. Zhang, et al., Chem. Eur. J. 24 (2018) 11667-11674. doi: 10.1002/chem.201801407
32. [32]
  B.W. Michel, A.R. Lippert, C.J. Chang, J. Am. Chem. Soc. 134 (2012) 15668-15671. doi: 10.1021/ja307017b
33. [33]
  W.J. Gong, Z.Q. Yu, Q.J. He, Chem. Synth. 1 (2021) 3.
34. [34]
  Q. Chen, E.J. Vazquez, S. Moghaddas, et al., J. Biol. Chem. 278 (2003) 36027-36031. doi: 10.1074/jbc.M304854200
35. [35]
  K.Y. Lu, P.Y. Lin, E.Y. Chuang, et al., ACS Appl. Mater. Interfaces 9 (2017) 5158-5172. doi: 10.1021/acsami.6b15515
36. [36]
  H. Huang, P. Zhang, B. Yu, et al., Dalton Trans. 44 (2015) 17335-17345. doi: 10.1039/C5DT02081F
37. [37]
  A.A. Abdel-Shafi, P.D. Beer, R.J. Mortimer, et al., J. Phys. Chem. A 104 (2000) 192-202. doi: 10.1021/jp991876z
38. [38]
  M.V. Berridge, P.M. Herst, A.S. Tan, Biotechnol. Annu. Rev. 11 (2005) 127-152.
39. [39]
  D.W. Zheng, B. Li, C.X. Li, et al., Adv. Mater. 29 (2017) 1703822. doi: 10.1002/adma.201703822
40. [40]
  B. Zhao, P. Zhao, Z. Jin, et al., J. Nanobiotechnol. 17 (2019) 75. doi: 10.1186/s12951-019-0507-x
41. [41]
  Z. Jin, Y. Duo, Y. Li, et al., Nano Today 38 (2021) 101197. doi: 10.1016/j.nantod.2021.101197
42. [42]
  M. Yuan, S. Liang, Y. Zhou, et al., Nano Lett. 21 (2021) 6042-6050. doi: 10.1021/acs.nanolett.1c01220
43. [43]
  S.W. Jin, D. Beis, T. Mitchell, et al., Development 132 (2005) 5199-5209. doi: 10.1242/dev.02087
1. [1]
  Tingting Hu , Chao Shen , Xueyan Wang , Fengbo Wu , Zhiyao He . Tumor microenvironment-sensitive polymeric nanoparticles for synergetic chemo-photo therapy. Chinese Chemical Letters, 2024, 35(11): 109562-. doi: 10.1016/j.cclet.2024.109562
2. [2]
  Shuxin Liu , Jinjuan Ma , Aiguo Wang , Nan Zheng . Decomposable and sono-enzyme co-triggered poly(sonosensitizers) for precise and hypotoxic sonodynamic therapy. Chinese Chemical Letters, 2025, 36(4): 110032-. doi: 10.1016/j.cclet.2024.110032
3. [3]
  Gongcheng Ma , Qihang Ding , Yuding Zhang , Yue Wang , Jingjing Xiang , Mingle Li , Qi Zhao , Saipeng Huang , Ping Gong , Jong Seung Kim . Palladium-free chemoselective probe for in vivo fluorescence imaging of carbon monoxide. Chinese Chemical Letters, 2024, 35(9): 109293-. doi: 10.1016/j.cclet.2023.109293
4. [4]
  Jumei Zhang , Ziheng Zhang , Gang Li , Hongjin Qiao , Hua Xie , Ling Jiang . Ligand-mediated reactivity in CO oxidation of yttrium-nickel monoxide carbonyl complexes. Chinese Chemical Letters, 2025, 36(2): 110278-. doi: 10.1016/j.cclet.2024.110278
5. [5]
  Fengyun Li , Zerong Pei , Shuting Chen , Gen li , Mengyang Liu , Liqin Ding , Jingbo Liu , Feng Qiu . Multifunctional nano-herb based on tumor microenvironment for enhanced tumor therapy of gambogic acid. Chinese Chemical Letters, 2024, 35(5): 108752-. doi: 10.1016/j.cclet.2023.108752
6. [6]
  Tao LIU , Yuting TIAN , Ke GAO , Xuwei HAN , Ru'nan MIN , Wenjing ZHAO , Xueyi SUN , Caixia YIN . A photothermal agent with high photothermal conversion efficiency and high stability for tumor therapy. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1622-1632. doi: 10.11862/CJIC.20240107
7. [7]
  Jiangshan Xu , Weifei Zhang , Zhengwen Cai , Yong Li , Long Bai , Shaojingya Gao , Qiang Sun , Yunfeng Lin . Tetrahedron DNA nanostructure/iron-based nanomaterials for combined tumor therapy. Chinese Chemical Letters, 2024, 35(11): 109620-. doi: 10.1016/j.cclet.2024.109620
8. [8]
  Chenlu Huang , Xinyu Yang , Qingyu Yu , Linhua Zhang , Dunwan Zhu . Gas-generating polymersomes-based amplified photoimmunotherapy for abscopal effect and tumor metastasis inhibition. Chinese Chemical Letters, 2024, 35(6): 109680-. doi: 10.1016/j.cclet.2024.109680
9. [9]
  Peide Zhu , Yangjia Liu , Yaoyao Tang , Siqi Zhu , Xinyang Liu , Lei Yin , Quan Liu , Zhiqiang Yu , Quan Xu , Dixian Luo , Juncheng Wang . Bi-doped carbon quantum dots functionalized liposomes with fluorescence visualization imaging for tumor diagnosis and treatment. Chinese Chemical Letters, 2024, 35(4): 108689-. doi: 10.1016/j.cclet.2023.108689
10. [10]
  Yihao Zhang , Yang Jiao , Xianchao Jia , Qiaojia Guo , Chunying Duan . Highly effective self-assembled porphyrin MOCs nanomaterials for enhanced photodynamic therapy in tumor. Chinese Chemical Letters, 2024, 35(5): 108748-. doi: 10.1016/j.cclet.2023.108748
11. [11]
  Zhe Li , Ping-Zhao Liang , Li Xu , Fei-Yu Yang , Tian-Bing Ren , Lin Yuan , Xia Yin , Xiao-Bing Zhang . Three positive charge nonapoptotic-induced photosensitizer with excellent water solubility for tumor therapy. Chinese Chemical Letters, 2024, 35(8): 109190-. doi: 10.1016/j.cclet.2023.109190
12. [12]
  An Lu , Yuhao Guo , Yi Yan , Lin Zhai , Xiangyu Wang , Weiran Cao , Zijie Li , Zhixia Zhao , Yujie Shi , Yuanjun Zhu , Xiaoyan Liu , Huining He , Zhiyu Wang , Jian-Cheng Wang . Nanomedicine integrating the lipidic derivative of 5-fluorouracil, miriplatin and PD-L1 siRNA for enhancing tumor therapy. Chinese Chemical Letters, 2024, 35(6): 108928-. doi: 10.1016/j.cclet.2023.108928
13. [13]
  Ji Liu , Dongsheng He , Tianjiao Hao , Yumin Hu , Yan Zhao , Zhen Li , Chang Liu , Daquan Chen , Qiyue Wang , Xiaofei Xin , Yan Shen . Gold mineralized "hybrid nanozyme bomb" for NIR-II triggered tumor effective permeation and cocktail therapy. Chinese Chemical Letters, 2024, 35(9): 109296-. doi: 10.1016/j.cclet.2023.109296
14. [14]
  Wenbin Zhou , Yafei Gao , Xinyu Feng , Yanqing Zhang , Cong Yang , Lanxi He , Fenghe Zhang , Xiaoguang Li , Qing Li . Biomimetic nanoplatform integrates FRET-enhanced photodynamic therapy and chemotherapy for cascaded revitalization of the tumor immune microenvironment in OSCC. Chinese Chemical Letters, 2025, 36(1): 109763-. doi: 10.1016/j.cclet.2024.109763
15. [15]
  Jia-Qi Feng , Xiang Tian , Rui-Ge Cao , Yong-Xiu Li , Wen-Long Liu , Rong Huang , Si-Yong Qin , Ai-Qing Zhang , Yin-Jia Cheng . An AIE-based theranostic nanoplatform for enhanced colorectal cancer therapy: Real-time tumor-tracking and chemical-enhanced photodynamic therapy. Chinese Chemical Letters, 2024, 35(12): 109657-. doi: 10.1016/j.cclet.2024.109657
16. [16]
  Yunjie Dang , Yanru Feng , Xiao Chen , Chaoxing He , Shujie Wei , Dingyang Liu , Jinlong Qi , Huaxing Zhang , Shaokun Yang , Zhiyun Niu , Bai Xiang . Development of a multi-level pH-responsive lipid nanoplatform for efficient co-delivery of siRNA and small-molecule drugs in tumor treatment. Chinese Chemical Letters, 2024, 35(12): 109660-. doi: 10.1016/j.cclet.2024.109660
17. [17]
  Jiaqi Huang , Renjiang Kong , Yanmei Li , Ni Yan , Yeyang Wu , Ziwen Qiu , Zhenming Lu , Xiaona Rao , Shiying Li , Hong Cheng . Feedback enhanced tumor targeting delivery of albumin-based nanomedicine to amplify photodynamic therapy by regulating AMPK signaling and inhibiting GSTs. Chinese Chemical Letters, 2024, 35(8): 109254-. doi: 10.1016/j.cclet.2023.109254
18. [18]
  Shangqian Zhang , Jiaxuan Li , Xuan Hu , Zelong Chen , Junliang Dong , Chenhao Hu , Shuang Chao , Yinghua Lv , Yuxin Pei , Zhichao Pei . H₂S and NIR light-driven nanomotors induce disulfidptosis for targeted anticancer therapy by enhancing disruption of tumor metabolic symbiosis. Chinese Chemical Letters, 2025, 36(1): 110314-. doi: 10.1016/j.cclet.2024.110314
19. [19]
  Mengjuan Sun , Muye Zhou , Yifang Xiao , Hailei Tang , Jinhua Chen , Ruitao Zhang , Chunjiayu Li , Qi Ya , Qian Chen , Jiasheng Tu , Qiyue Wang , Chunmeng Sun . Reversibly size-switchable polyion complex micelles for antiangiogenic cancer therapy. Chinese Chemical Letters, 2024, 35(7): 109110-. doi: 10.1016/j.cclet.2023.109110
20. [20]
  Qinyu Zhao , Yunchao Zhao , Songjing Zhong , Zhaoyang Yue , Zhuoheng Jiang , Shaobo Wang , Quanhong Hu , Shuncheng Yao , Kaikai Wen , Linlin Li . Urchin-like piezoelectric ZnSnO₃/Cu₃P p-n heterojunction for enhanced cancer sonodynamic therapy. Chinese Chemical Letters, 2024, 35(12): 109644-. doi: 10.1016/j.cclet.2024.109644

Get Citation

PDF

XML

Metrics

PDF Downloads(5)
Abstract views(548)
HTML views(52)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142