Citation: Shan-Xiu Ni, Yan-Lin Li, Hui-Qi Ni, Yu-Xiang Bi, Jie Sheng, Xi-Sheng Wang. Nickel-catalyzed hydromonofluoromethylation of unactivated alkenes for expedient construction of primary alkyl fluorides[J]. Chinese Chemical Letters, ;2023, 34(3): 107614. doi: 10.1016/j.cclet.2022.06.037 shu

Nickel-catalyzed hydromonofluoromethylation of unactivated alkenes for expedient construction of primary alkyl fluorides

Department of Chemistry, University of Science and Technology of China, Hefei 230026, China

xswang77@ustc.edu.cn

Received Date: 24 April 2022
Revised Date: 13 June 2022
Accepted Date: 14 June 2022
Available Online: 18 June 2022

Figures(6)

A nickel-catalyzed direct hydromonofluoromethylation of unactivated olefins with industrial raw fluoroiodomethane is developed, furnishing various primary alkyl fluorides in a step-economic manner. The key factor to success is the use of pyridine-oxazoline as ligand and (MeO)₂MeSiH as the hydrogen source. This transformation demonstrates high efficiency, mild conditions, good functional-group compatibility and great potential in the drug discovery.
- Hydromonofluoromethylation,
- Unactivated alkenes,
- Nickel-catalysis,
- Primary fluorides,
- Ni-H species
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