Citation: Ruijie Liu, Li He, Maoyu Liu, Lu Chen, Jun Hou, Jianyou Shi, Lan Bai. Erythrocyte membrane encapsulated gambogic acid nanoparticles as a therapeutic for hepatocellular carcinoma[J]. Chinese Chemical Letters, ;2023, 34(1): 107575. doi: 10.1016/j.cclet.2022.05.089 shu

Erythrocyte membrane encapsulated gambogic acid nanoparticles as a therapeutic for hepatocellular carcinoma

Ruijie Liu ^{a, 1} ,
Li He ^{b, 1} ,
Maoyu Liu ^c ,
Lu Chen ^c ,
Jun Hou ^{a, *,} ,
Jianyou Shi ^{c, *,} ,
Lan Bai ^{c, *,}

a.
Affiliated Hospital of Southwest Jiaotong University/Department of Cardiology, Chengdu Third People's Hospital, Chengdu 610031, China
b.
Department of Pharmacy, Jianyang Chinese Medicine Hospital, Chengdu 641499, China
c.
Personalized Drug Therapy Key Laboratory of Sichuan Province, Department of Pharmacy, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China

jun_hou@yeah.net

shijianyoude@126.com

blci@163.com

Received Date: 29 December 2021
Revised Date: 24 May 2022
Accepted Date: 31 May 2022
Available Online: 3 June 2022

Figures(4)

Gambogic acid (GA) is a potential clinical anticancer drug that can exert antitumor effects via various molecular mechanisms. Notwithstanding, GA's low water solubility, poor stability, short half-life, and unavoidable toxic side effects have significantly hampered its clinical application. Erythrocyte membrane-coated nanoparticles (RBCM-NPs) improve drug's physicochemical properties, biocompatibility, and pharmacokinetic behaviors, allowing for long-term drug circulation and passive targeting. In this study, a novel biomimetic drug delivery system (DDS) against hepatocellular carcinoma was prepared by covering RBCM on GPP-NPs (GA-loaded mPEG-PLA NPs) to develop the RBC@GPP-NPs. In comparison to RBCM-free nanoparticles and free GA, RBC@GPP-NPs improved the drug's water solubility, stability, safety, and anti-tumor activity in vivo. We expect that this bionic nanoparticle composite can expand the clinical applicability of GA and provide a feasible solution for the research and development of GA's nano-formulation.
- Gambogic acid,
- Erythrocyte membrane,
- Drug delivery systems,
- Biomimetic nanoparticles,
- Hepatocellular carcinoma
1. [1]
  A. Hefnawy, I.H. Khalil, K. Arafa, M. Emara, I.M. El-Sherbiny, Int. J. Nanomed.15 (2020) 821-837. doi: 10.2147/ijn.s240359
2. [2]
  H. Sung, J. Ferlay, R.L. Siegel, et al., CA: Cancer J. Clin. 71 (2021) 209-249. doi: 10.3322/caac.21660
3. [3]
  J. Ferlay, M. Colombet, I. Soerjomataram, et al., Int. J. Cancer 149 (2021) 778-789. doi: 10.1002/ijc.33588
4. [4]
  T. Sun, Y.S. Zhang, B. Pang, et al., Angew. Chem. Int. Ed. 53 (2014) 12320-12364.
5. [5]
  D.A. Dias, S. Urban, U. Roessner, Metabolites 2 (2012) 303-336. doi: 10.3390/metabo2020303
6. [6]
  P.N.H. Lee, W.S. Ho, Oncol. Rep. 29 (2013) 1744-1750. doi: 10.3892/or.2013.2291
7. [7]
  M.S. Park, N.H. Kim, C.W. Kang, C.W. Oh, G.D. Kim, Drug. Dev. Res. 76 (2015) 132-142. doi: 10.1002/ddr.21249
8. [8]
  Z. Ke, L. Yang, H. Wu, et al., Int. J. Pharm. 545 (2018) 306-317. doi: 10.1016/j.ijpharm.2018.04.016
9. [9]
  E. Hatami, M. Jaggi, S.C. Chauhan, M.M. Yallapu, Biochim. Biophys. Acta Rev. Cancer 1874 (2020) 188381. doi: 10.1016/j.bbcan.2020.188381
10. [10]
  Y. Wang, X. Wang, J. Zhang, et al., Chin. Chem. Lett. 30 (2019) 885-888. doi: 10.1016/j.cclet.2019.02.018
11. [11]
  L. Wu, H. Guo, H. Sun, et al., Anti-Cancer Drugs 27 (2016) 988-1000. doi: 10.1097/CAD.0000000000000416
12. [12]
  K. Hao, X.Q. Liu, G.J. Wang, X.P. Zhao, Eur. J. Drug Metab. Pharmacokinet. 32 (2007) 63-68. doi: 10.1007/BF03190993
13. [13]
  L. He, Y. Ling, L. Fu, et al., Bioorg. Med. Chem. Lett. 22 (2012) 289-292. doi: 10.1016/j.bmcl.2011.11.016
14. [14]
  E. Blanco, T. Sangai, A. Hsiao, et al., Cancer. Lett. 334 (2013) 245-252. doi: 10.1016/j.canlet.2012.07.027
15. [15]
  L. Cai, N. Qiu, M. Xiang, et al., Int. J. Nanomed. 9 (2014) 243-255.
16. [16]
  S. Adepu, H. Luo, S. Ramakrishna, Int. J. Mol. Sci. 22 (2021) 5433. doi: 10.3390/ijms22115433
17. [17]
  S. Acharya, S.K. Sahoo, Adv. Drug Delivery Rev. 63 (2011) 170-183. doi: 10.1016/j.addr.2010.10.008
18. [18]
  P.A. Gunatillake, R. Adhikari, Eur. Cells Mater. 5 (2003) 1-16. doi: 10.22203/eCM.v005a01
19. [19]
  W. Pei, B. Huang, S. Chen, et al., Int. J. Nanomed. 15 (2020) 10151-10167. doi: 10.2147/ijn.s285952
20. [20]
  Y. Wang, K. Zhang, T. Li, et al., Theranostics 11 (2021) 164-180. doi: 10.7150/thno.47841
21. [21]
  Q. Zhao, X. Sun, B. Wu, et al., J. Nanobiotechnol. 19 (2021) 8. doi: 10.1186/s12951-020-00738-8
22. [22]
  E.T. Dams, P. Laverman, W.J. Oyen, et al., J. Pharmacol. Exp. Ther. 292 (2000) 1071-1079.
23. [23]
  D. Dehaini, X. Wei, R.H. Fang, et al., Adv. Mater. 29 (2017) 1606209. doi: 10.1002/adma.201606209
24. [24]
  M. Bhateria, R. Rachumallu, R. Singh, R.S. Bhatta, Expert. Opin. Drug. Deliv. 11 (2014) 1219-1236. doi: 10.1517/17425247.2014.927436
25. [25]
  Y. Mao, C. Zou, Y. Jiang, D. Fu, Chin. Chem. Lett. 32 (2021) 990-998. doi: 10.1016/j.cclet.2020.08.048
26. [26]
  Z. Zhang, H. Qian, M. Yang, et al., Int. J. Nanomed. 12 (2017) 1593-1605. doi: 10.2147/IJN.S127256
27. [27]
  C. Guo, X. Hou, Y. Liu, et al., Phytomedicine. 80 (2021) 153356. doi: 10.1016/j.phymed.2020.153356
28. [28]
  Z. Li, G. Yang, L. Han, et al., J. Nanobiotechnol. 19 (2021) 360. doi: 10.1186/s12951-021-01095-w
29. [29]
  L.M. Bush, C.P. Healy, S.B. Javdan, J.C. Emmons, T.L. Deans, Trends. Pharmacol. Sci. 42 (2021) 106-118. doi: 10.1016/j.tips.2020.11.008
30. [30]
  Z. Zhang, H. Qian, J. Huang, et al., Int. J. Nanomed. 13 (2018) 4961-4975. doi: 10.2147/IJN.S170148
31. [31]
  B.T. Luk, C.M.J. Hu, R.H. Fang, et al., Nanoscale 6 (2014) 2730-2737.
32. [32]
  K. Ou, X. Xu, S. Guan, et al., Adv. Funct. Mater. 30 (2020) 1907857. doi: 10.1002/adfm.201907857
33. [33]
  X. You, L. Wang, L. Wang, J. Wu, Adv. Funct. Mater. 31 (2021) 2100805. doi: 10.1002/adfm.202100805
34. [34]
  C. Jiménez-Jiménez, M. Manzano, M. Vallet-Regí, Biology (Basel)9 (2020) 406. doi: 10.3390/biology9110406
35. [35]
  L. He, T. Nie, X. Xia, et al., Adv. Funct. Mater. 29 (2019) 1901240. doi: 10.1002/adfm.201901240
36. [36]
  X. Liu, X. Zhong, C. Li, Chin. Chem. Lett. 32 (2021) 2347-2358. doi: 10.1016/j.cclet.2021.03.015
1. [1]
  Zhiyu Yu , Xiang Luo , Cheng Zhang , Xin Lu , Xiaohui Li , Pan Liao , Zhongqiu Liu , Rong Zhang , Shengtao Wang , Zhiqiang Yu , Guochao Liao . Mitochondria-targeted carrier-free nanoparticles based on dihydroartemisinin against hepatocellular carcinoma. Chinese Chemical Letters, 2024, 35(10): 109519-. doi: 10.1016/j.cclet.2024.109519
2. [2]
  Ningyue Xu , Jun Wang , Lei Liu , Changyang Gong . Injectable hydrogel-based drug delivery systems for enhancing the efficacy of radiation therapy: A review of recent advances. Chinese Chemical Letters, 2024, 35(8): 109225-. doi: 10.1016/j.cclet.2023.109225
3. [3]
  Fengyun Li , Zerong Pei , Shuting Chen , Gen li , Mengyang Liu , Liqin Ding , Jingbo Liu , Feng Qiu . Multifunctional nano-herb based on tumor microenvironment for enhanced tumor therapy of gambogic acid. Chinese Chemical Letters, 2024, 35(5): 108752-. doi: 10.1016/j.cclet.2023.108752
4. [4]
  Qiuye Wang , Yabing Sun , Liangxue Lai , Haijing Cui , Yonglong Ye , Ming Yang , Weihao Zhu , Bo Yuan , Quanliang Mao , Wenzhi Ren , Aiguo Wu . MMP-9-responsive probe for fluorescence-magnetic resonance dual-mode imaging of hepatocellular carcinoma models with different metastatic capacities. Chinese Chemical Letters, 2025, 36(4): 110212-. doi: 10.1016/j.cclet.2024.110212
5. [5]
  Jun Xiong , Ke-Ke Chen , Neng-Bin Xie , Wei Chen , Wen-Xuan Shao , Tong-Tong Ji , Si-Yu Yu , Yu-Qi Feng , Bi-Feng Yuan . Demethylase-assisted site-specific detection of N¹-methyladenosine in RNA. Chinese Chemical Letters, 2024, 35(5): 108953-. doi: 10.1016/j.cclet.2023.108953
6. [6]
  Jiechen Liu , Xiaoguang Li , Ruiyang Xia , Yuqi Wang , Fenghe Zhang , Yongzhi Pang , Qing Li . Efficient suppression of oral squamous cell carcinoma through spatial dimension conversion drug delivery systems-enabled immunomodulatory-photodynamic therapy. Chinese Chemical Letters, 2024, 35(12): 109619-. doi: 10.1016/j.cclet.2024.109619
7. [7]
  Fengjie Liu , Fansu Meng , Zhenjiang Yang , Huan Wang , Yuehong Ren , Yu Cai , Xingwang Zhang . Exosome-biomimetic nanocarriers for oral drug delivery. Chinese Chemical Letters, 2024, 35(9): 109335-. doi: 10.1016/j.cclet.2023.109335
8. [8]
  Linghui Zou , Meng Cheng , Kaili Hu , Jianfang Feng , Liangxing Tu . Vesicular drug delivery systems for oral absorption enhancement. Chinese Chemical Letters, 2024, 35(7): 109129-. doi: 10.1016/j.cclet.2023.109129
9. [9]
  Yujie Li , Ya-Nan Wang , Yin-Gen Luo , Hongcai Yang , Jinrui Ren , Xiao Li . Advances in synthetic biology-based drug delivery systems for disease treatment. Chinese Chemical Letters, 2024, 35(11): 109576-. doi: 10.1016/j.cclet.2024.109576
10. [10]
  Jinyu Guo , Yandai Lin , Shaohua He , Yueqing Chen , Fenglu Li , Renjie Ruan , Gaoxing Pan , Hexin Nan , Jibin Song , Jin Zhang . Utilizing dual-responsive iridium(Ⅲ) complex for hepatocellular carcinoma: Integrating photoacoustic imaging with chemotherapy and photodynamic therapy. Chinese Chemical Letters, 2024, 35(9): 109537-. doi: 10.1016/j.cclet.2024.109537
11. [11]
  Xingqun Pu , Rongrong Liu , Yuting Xie , Chenjing Yang , Jingyi Chen , Baoling Guo , Chun-Xia Zhao , Peng Zhao , Jian Ruan , Fangfu Ye , David A Weitz , Dong Chen . One-step preparation of biocompatible amphiphilic dimer nanoparticles with tunable particle morphology and surface property for interface stabilization and drug delivery. Chinese Chemical Letters, 2025, 36(3): 109820-. doi: 10.1016/j.cclet.2024.109820
12. [12]
  Yuanzheng Wang , Chen Zhang , Shuyan Han , Xiaoli Kong , Changyun Quan , Jun Wu , Wei Zhang . Cancer cell membrane camouflaged biomimetic gelatin-based nanogel for tumor inhibition. Chinese Chemical Letters, 2024, 35(11): 109578-. doi: 10.1016/j.cclet.2024.109578
13. [13]
  Ke Gong , Jinghan Liao , Jiangtao Lin , Quan Wang , Zhihua Wu , Liting Wang , Jiali Zhang , Yi Dong , Yourong Duan , Jianhua Chen . Mitochondria-targeted nanoparticles overcome chemoresistance via downregulating BACH1/CD47 axis in ovarian carcinoma. Chinese Chemical Letters, 2024, 35(5): 108888-. doi: 10.1016/j.cclet.2023.108888
14. [14]
  Lihang Wang , Mary Li Javier , Chunshan Luo , Tingsheng Lu , Shudan Yao , Bing Qiu , Yun Wang , Yunfeng Lin . Research advances of tetrahedral framework nucleic acid-based systems in biomedicine. Chinese Chemical Letters, 2024, 35(11): 109591-. doi: 10.1016/j.cclet.2024.109591
15. [15]
  Xubin Qian , Lei Xu , Xu Ge , Zhun Liu , Cheng Fang , Jianbing Wang , Junfeng Niu . Can perfluorooctanoic acid be effectively degraded using β-PbO₂ reactive electrochemical membrane?. Chinese Chemical Letters, 2024, 35(7): 109218-. doi: 10.1016/j.cclet.2023.109218
16. [16]
  Jisheng Liu , Junli Chen , Xifeng Zhang , Yin Wu , Xin Qi , Jie Wang , Xiang Gao . Red blood cell membrane-coated FLT3 inhibitor nanoparticles to enhance FLT3-ITD acute myeloid leukemia treatment. Chinese Chemical Letters, 2024, 35(9): 109779-. doi: 10.1016/j.cclet.2024.109779
17. [17]
  Dexuan Xiao , Tianyu Chen , Tianxu Zhang , Sirong Shi , Mei Zhang , Xin Qin , Yunkun Liu , Longjiang Li , Yunfeng Lin . Transdermal treatment for malignant melanoma by aptamer-modified tetrahedral framework nucleic acid delivery of vemurafenib. Chinese Chemical Letters, 2024, 35(4): 108602-. doi: 10.1016/j.cclet.2023.108602
18. [18]
  Zhilong Xie , Guohui Zhang , Ya Meng , Yefei Tong , Jian Deng , Honghui Li , Qingqing Ma , Shisong Han , Wenjun Ni . A natural nano-platform: Advances in drug delivery system with recombinant high-density lipoprotein. Chinese Chemical Letters, 2024, 35(11): 109584-. doi: 10.1016/j.cclet.2024.109584
19. [19]
  Wenjia Wang , Xingyue He , Xiaojie Wang , Tiantian Zhao , Osamu Muraoka , Genzoh Tanabe , Weijia Xie , Tianjiao Zhou , Lei Xing , Qingri Jin , Hulin Jiang . Glutathione-depleted cyclodextrin pseudo-polyrotaxane nanoparticles for anti-inflammatory oxaliplatin (Ⅳ) prodrug delivery and enhanced colorectal cancer therapy. Chinese Chemical Letters, 2024, 35(4): 108656-. doi: 10.1016/j.cclet.2023.108656
20. [20]
  Yi Cao , Xiaojiao Ge , Yuanyuan Wei , Lulu He , Aiguo Wu , Juan Li . Tumor microenvironment-activatable neuropeptide-drug conjugates enhanced tumor penetration and inhibition via multiple delivery pathways and calcium deposition. Chinese Chemical Letters, 2024, 35(4): 108672-. doi: 10.1016/j.cclet.2023.108672

Get Citation

PDF

XML

Metrics

PDF Downloads(11)
Abstract views(700)
HTML views(80)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142