Citation: Xiaojian Ren, Qiang Liu, Zhixiang Wang, Xiangyu Chen. Visible-light-induced direct hydrodifluoromethylation of alkenes with difluoromethyltriphenylphosphonium iodide salt[J]. Chinese Chemical Letters, ;2023, 34(1): 107473. doi: 10.1016/j.cclet.2022.04.071 shu

Visible-light-induced direct hydrodifluoromethylation of alkenes with difluoromethyltriphenylphosphonium iodide salt

School of Chemical Sciences, University of the Chinese Academy of Sciences, Beijing 100049, China

zxwang@ucas.ac.cn

chenxiangyu20@ucas.ac.cn

Received Date: 11 February 2022
Revised Date: 25 April 2022
Accepted Date: 25 April 2022
Available Online: 30 April 2022

Figures(4)

Photoredox-catalyzed hydrodifluoromethylation of alkenes has become an effective method to introduce difluoromethyl group into organic molecules. As the reported methods involve either photocatalysts or superstoichiometric amounts of additives, we herein describe a simple alternative without using photocatalyst or additive for the hydrodifluoromethylation of alkenes, through photoactivation of difluoromethyltriphenylphosphonium iodide salt. Mechanistic studies shed light on how the transformation takes place.
- Hydrodifluoromethylation,
- Difluoromethyltriphenylphosphonium iodide salt,
- Alkenes,
- DFT studies,
- Photoredox
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