Citation: Kosheli Thapa Magar, George Frimpong Boafo, Makhloufi Zoulikha, Xiaohong Jiang, Xiaotong Li, Qingqing Xiao, Xuyang Xing, Xiaochun Wang, Lifang Fan, Zhenfeng Wu, Wei He. Metal phenolic network-stabilized nanocrystals of andrographolide to alleviate macrophage-mediated inflammation in-vitro[J]. Chinese Chemical Letters, ;2023, 34(1): 107453. doi: 10.1016/j.cclet.2022.04.051 shu

Metal phenolic network-stabilized nanocrystals of andrographolide to alleviate macrophage-mediated inflammation in-vitro

a.
School of Pharmacy, China Pharmaceutical University, Nanjing 211198, China
b.
Jiangsu Aosaikang Pharmaceutical Co., Ltd., Nanjing 211112, China
c.
Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, China

zfwu527@163.com

weihe@cpu.edu.cn

Received Date: 15 December 2021
Revised Date: 13 April 2022
Accepted Date: 19 April 2022
Available Online: 23 April 2022

Figures(4)

Macrophages play a crucial role in initiating, maintaining, and resolving inflammation through the phenotypic shift, inducing or inhibiting the production of inflammatory cytokines. Therefore, macrophages are potential targets for treating inflammatory diseases. Andrographolide (AND) is a potent anti-inflammatory drug that can reduce pro-inflammatory cytokines and suppress NF-κB /MAPK pathway in activated macrophages. Although AND has many medicinal properties, its lower water solubility and first-pass effect in the liver have hindered its clinical application. In this context, by using a metal phenolic network as a stabilizer, we designed and prepared highly stabilized AND nanocrystals (AND-MPN Ns) with high drug loading capacity to facilitate the clinical application of AND. Our findings showed that AND-MPN Ns could be used to enhance the anti-inflammation in-vitro via macrophage polarization, reducing pro-inflammatory cytokines IL-6 and TNF-α, and suppressing the NF-κB signaling pathway activation. The results demonstrated the potential of AND-MPN Ns to combat inflammatory diseases effectively.
- Inflammation,
- Macrophages,
- Andrographolide,
- Metal phenolic network,
- Nanocrystals
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