Citation: Xulin Hu, Weiming Zhao, Zhen Zhang, Jianping Xie, Jian He, Jianfei Cao, Qing Li, Yajing Yan, Chengdong Xiong, Kainan Li. Novel 3D printed shape-memory PLLA-TMC/GA-TMC scaffolds for bone tissue engineering with the improved mechanical properties and degradability[J]. Chinese Chemical Letters, ;2023, 34(1): 107451. doi: 10.1016/j.cclet.2022.04.049 shu

Novel 3D printed shape-memory PLLA-TMC/GA-TMC scaffolds for bone tissue engineering with the improved mechanical properties and degradability

Xulin Hu ^a ,
Weiming Zhao ^a ,
Zhen Zhang ^a ,
Jianping Xie ^a ,
Jian He ^d ,
Jianfei Cao ^e ,
Qing Li ^b ,
Yajing Yan ^a ,
Chengdong Xiong ^{b, c, *,} ,
Kainan Li ^{a, *,}

a.
Clinical Medical College & Affiliated Hospital of Chengdu University, Chengdu University, Chengdu 610081, China
b.
Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China
c.
University of Chinese Academy of Sciences, Beijing 100049, China
d.
College of Medical, Henan University of Science and Technology, Luoyang 471023, China
e.
School of Materials and Environmental Engineering, Chengdu Technological University, Chengdu 610031, China

xiongcdcioc@163.com

Likainan1961@126.com

Received Date: 14 January 2022
Revised Date: 5 April 2022
Accepted Date: 19 April 2022
Available Online: 23 April 2022

Figures(3)

The biodegradable substitution materials for bone tissue engineering have been a research hotspot. As is known to all, the biodegradability, biocompatibility, mechanical properties and plasticity of the substitution materials are the important indicators for the application of implantation materials. In this article, we reported a novel binary substitution material by blending the poly(lactic-acid)-co-(trimethylene-carbonate) and poly(glycolic-acid)-co-(trimethylene-carbonate), which are both biodegradable polymers with the same segment of flexible trimethylene-carbonate in order to accelerate the degradation rate of poly(lactic-acid)-co-(trimethylene carbonate) substrate and improve its mechanical properties. Besides, we further fabricate the porous poly(lactic-acid)-co-(trimethylene-carbonate)/poly(glycolic-acid)-co-(trimethylene-carbonate) scaffolds with uniform microstructure by the 3D extrusion printing technology in a mild printing condition. The physicochemical properties of the poly(lactic-acid)-co-(trimethylene-carbonate)/poly(glycolic-acid)-co-(trimethylene-carbonate) and the 3D printing scaffolds were investigated by universal tensile dynamometer, fourier transform infrared reflection (FTIR), scanning electron microscope (SEM) and differential scanning calorimeter (DSC). Meanwhile, the degradability of the PLLA-TMC/GA-TMC was performed in vitro degradation assays. Compared with PLLA-TMC group, PLLA-TMC/GA-TMC groups maintained the decreasing T_g, higher degradation rate and initial mechanical performance. Furthermore, the PLLA-TMC/GA-TMC 3D printing scaffolds provided shape-memory ability at 37 ℃. In summary, the PLLA-TMC/GA-TMC can be regarded as an alternative substitution material for bone tissue engineering.
- Bone scaffolds,
- Biodegradable polymers,
- 3D printed,
- Shape memory,
- Tissue engineering
1. [1]
  C. Chen, Y. Li, X. Yu, et al., Chin. Chem. Lett. 29 (2018) 1609–1612. doi: 10.1016/j.cclet.2018.02.010
2. [2]
  D.W.J.B. Hutmacher, Biomaterials 21 (2000) 2529–2543. doi: 10.1016/S0142-9612(00)00121-6
3. [3]
  S.K.L. Levengood, M.J.J. o. M.C.B. Zhang, J. Mater. Chem. B 2 (2014) 3161–3184. doi: 10.1039/c4tb00027g
4. [4]
  J.R. Mauney, C. Jaquiéry, V. Volloch, et al., Biomaterials 26 (2005) 3173–3185. doi: 10.1016/j.biomaterials.2004.08.020
5. [5]
  K. Rezwan, Q.Z. Chen, J.J. Blaker, A.R. Boccaccini, Biomaterials 27 (2006) 3413–3431. doi: 10.1016/j.biomaterials.2006.01.039
6. [6]
  A.J. Salgado, O.P. Coutinho, R.L. Reis, Macromol. Biosci. 4 (2004) 743–765. doi: 10.1002/mabi.200400026
7. [7]
  T. Jiang, W.I. Abdel-Fattah, C.T. Laurencin, Biomaterials 27 (2006) 4894–4903. doi: 10.1016/j.biomaterials.2006.05.025
8. [8]
  W. Amass, A. Amass, B.J.P.I. Tighe, Polym. Int. 47 (1998) 89–144. doi: 10.1002/(SICI)1097-0126(1998100)47:2<89::AID-PI86>3.0.CO;2-F
9. [9]
  D.K. Gilding, A.M. Reed, Polymer 20 (1979) 1459–1464. doi: 10.1016/0032-3861(79)90009-0
10. [10]
  L.S. Nair, C.T. Laurencin, Prog. Polym. Sci. 32 (2007) 762–798. doi: 10.1016/j.progpolymsci.2007.05.017
11. [11]
  Q. Wang, J. Xu, H. Jin, et al., Chin. Chem. Lett. 28 (2017) 1801–1807. doi: 10.1016/j.cclet.2017.07.011
12. [12]
  J.E. Bergsma, J. Oral. Maxil. Surg. 56 (1998) 614–615. doi: 10.1016/S0278-2391(98)90462-1
13. [13]
  B. Buntner, M. Nowak, J. Kasperczyk, et al., J. Control. Release 56 (1998) 159–167. doi: 10.1016/S0168-3659(98)00085-6
14. [14]
  S. Lee, H. Shin, Adv. Drug Deliv. Rev. 59 (2007) 339–359. doi: 10.1016/j.addr.2007.03.016
15. [15]
  M.F. Maitz, Biosurf. Biotribol. 1 (2015) 161–176. doi: 10.1016/j.bsbt.2015.08.002
16. [16]
  J. Hua, K. Gebarowska, P. Dobrzynski, et al., J. Polym. Sci. Pol. Chem. 47 (2009) 3869–3879. doi: 10.1002/pola.23453
17. [17]
  A.C. Motta, V. de Miranda Fedrizzi, M.L.P. Barbo, E.A.R. Duek, Polym. Bull. 75 (2018) 4515–4529. doi: 10.1007/s00289-018-2283-4
18. [18]
  X. Hu, J. He, X. Yong, et al., Colloids Surf. B: Biointerfaces 195 (2020) 111218. doi: 10.1016/j.colsurfb.2020.111218
19. [19]
  X. Hu, S. Mi, J. Lu, et al., Colloids Surf. A: Physicochem. Eng. Asp. 615 (2021) 126220. doi: 10.1016/j.colsurfa.2021.126220
20. [20]
  S. Mi, X. Hu, Z. Lin, et al., Colloids Surf. A: Physicochem. Eng. Asp. 622 (2021) 126594. doi: 10.1016/j.colsurfa.2021.126594
21. [21]
  C. Sanson, C. Schatz, J. Le Meins, et al., Langmuir 26 (2010) 2751–2760. doi: 10.1021/la902786t
22. [22]
  A.H.K. Chou, R.Z. LeGeros, Z. Chen, Y. Li, Implant Dent. 16 (2007) 89–100. doi: 10.1097/ID.0b013e318031224a
23. [23]
  O. Guillaume, M.A. Geven, C.M. Sprecher, et al., Acta Biomater. 54 (2017) 386–398. doi: 10.1016/j.actbio.2017.03.006
24. [24]
  A.P. Pêgo, D.W. Grijpma, J. Feijen, Polymer 44 (2003) 6495–6504. doi: 10.1016/S0032-3861(03)00668-2
25. [25]
  P.V. Giannoudis, T.A. Einhorn, D. Marsh, Injury 38 (2007) S3–S6.
26. [26]
  O. Gauthier, J. Bouler, E. Aguado, et al., Biomaterials 19 (1998) 133–139. doi: 10.1016/S0142-9612(97)00180-4
27. [27]
  K. Huang, G. Liu, Z. Gu, J. Wu, Chin. Chem. Lett. 31 (2020) 3190–3194. doi: 10.1016/j.cclet.2020.07.002
28. [28]
  J. Amirian, N.T.B. Linh, Y.K. Min, B. Lee, Int. J. Biol. Macromol. 76 (2015) 10–24. doi: 10.1016/j.ijbiomac.2015.02.021
29. [29]
  J. Davies, Anat. Rec. 245 (1996) 426–445. doi: 10.1002/(SICI)1097-0185(199606)245:2<426::AID-AR21>3.0.CO;2-Q
30. [30]
  C.A. Vacanti, J.P. Vacanti, R. Langer, ACS Symp. Ser. 540 (1993) 16–34.
31. [31]
  C. Sanson, C. Schatz, J.F. Le Meins, et al., J. Control. Release 147 (2010) 428–435. doi: 10.1016/j.jconrel.2010.07.123
32. [32]
  Q. Zhao, J. Wang, H. Cui, et al., Adv. Funct. Mater. 28 (2018) 1801027. doi: 10.1002/adfm.201801027
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