Citation: Xiang Sun, Kuiliang Li, Shuangshuang Zhao, Zhenggen Zha, Zhiyong Wang. Construction of chiral 3-alkenyl-3-substituted oxindoles by stereoselective direct alkenylation of isatin derivatives and 3-vinylindoles[J]. Chinese Chemical Letters, ;2022, 33(12): 5106-5110. doi: 10.1016/j.cclet.2022.04.032 shu

Construction of chiral 3-alkenyl-3-substituted oxindoles by stereoselective direct alkenylation of isatin derivatives and 3-vinylindoles

Hefei National Research Center for Physical Sciences at the Microscale, Center for Excellence in Molecular Synthesis of Chinese Academy of Sciences, School of Chemistry and Materials Science, University of Science and Technology of China, Hefei 230026, China

zwang3@ustc.edu.cn

Received Date: 16 February 2022
Revised Date: 9 April 2022
Accepted Date: 12 April 2022
Available Online: 17 April 2022

Figures(5)

An efficient asymmetric alkenylation between 3-vinylindoles and isatin derivatives was developed under catalysis of a chiral copper complex. A series of optically active 3-alkenyl-3-substituted oxindoles were obtained in excellent yields and stereoselectivities. The reaction mechanism was proposed and supported by DFT calculation.
- Asymmetric reaction,
- Direct alkenylation,
- Chiral Cu(Ⅱ)-complex,
- 3-Vinylindole,
- Isatin derivatives
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