Citation: Yao Wu, Zhiyan Ma, Jing Shi, Xiaoqiang Sun, Ke Yang, Zheng-Yi Li. Supramolecular interaction controlled and calix[4]arene ligand assisted Pd-catalyzed C(sp³)−H arylation of aliphatic aldehydes[J]. Chinese Chemical Letters, ;2022, 33(12): 5116-5119. doi: 10.1016/j.cclet.2022.03.125 shu

Supramolecular interaction controlled and calix[4]arene ligand assisted Pd-catalyzed C(sp³)−H arylation of aliphatic aldehydes

Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China

keyang@cczu.edu.cn

zyli@cczu.edu.cn

Received Date: 24 January 2022
Revised Date: 31 March 2022
Accepted Date: 31 March 2022
Available Online: 3 April 2022

Figures(5)

A calix[4]arene ligand assisted direct β-C−H arylation of tertiary aliphatic aldehydes has been developed via a Pd-catalyzed C(sp³)−H functionalization process. This strategy exhibited good functional group compatibility and C−H bond site-selectivity. Mechanism studies have shown that both synergistic effect and cationic-π supramolecular interaction between calixarene cavity and transition-metal catalytic center may play an important role in this catalytic cycle. This complementary method would be used in organic and medical chemistry due to the importance of tertiary aliphatic aldehydes.
- Supramolecular interaction,
- Palladium-catalyzed,
- C−H activation,
- Calixarene,
- Aliphatic aldehyde
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沈阳化工大学材料科学与工程学院沈阳 110142

Supramolecular interaction controlled and calix[4]arene ligand assisted Pd-catalyzed C(sp3)−H arylation of aliphatic aldehydes

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通讯作者: 陈斌, bchen63@163.com

Supramolecular interaction controlled and calix[4]arene ligand assisted Pd-catalyzed C(sp³)−H arylation of aliphatic aldehydes