Citation: Jingfang Zhang, Xiaoqiang Lei, Yazi Wei, Hui Liu, Qinglan Guo, Tiantai Zhang, Jiangong Shi. Two unique C₂₁-diterpenoid alkaloids from Aconitum carmichaelii[J]. Chinese Chemical Letters, ;2022, 33(12): 5047-5050. doi: 10.1016/j.cclet.2022.03.104 shu

Two unique C₂₁-diterpenoid alkaloids from Aconitum carmichaelii

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China

guonina@imm.ac.cn

ttzhang@imm.ac.cn

shijg@imm.ac.cn

Received Date: 26 February 2022
Revised Date: 28 March 2022
Accepted Date: 29 March 2022
Available Online: 1 April 2022

Figures(5)

Two sulfonated diterpenoid alkaloids possessing different but related novel carbon skeletons, named aconidenusulfonine A (1) and 12, 16-secoaconidenusulfonine A (2), respectively, were isolated as minor components from an aqueous extract of the lateral roots of Aconitum carmichaelii ("Fu Zi"). The structures of 1 and 2, representing the first two C₂₁-diterpenoid alkaloids from nature, were determined by analysis of various spectroscopic data and chemical transformation, of which 1 was further proved by single-crystal X-ray diffraction. Especially, 1 exhibited dose-depended analgesic activity consistent with the clinical function of Fu Zi.
- Ranunculaceae,
- Aconitum carmichaelii,
- C₂₁-diterpenoid alkaloid,
- Aconidenusulfonine,
- Analgesic activity
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Two unique C21-diterpenoid alkaloids from Aconitum carmichaelii

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Two unique C₂₁-diterpenoid alkaloids from Aconitum carmichaelii