Citation: Yulin Peng, Yibo Chang, Chengpeng Sun, Weiyi Wang, Chao Wang, Yan Tian, Baojing Zhang, Sa Deng, Wenyu Zhao, Xiaochi Ma. Octacyclic and decacyclic ent–abietane dimers with cytotoxic activity from Euphorbia fischeriana steud.[J]. Chinese Chemical Letters, ;2022, 33(9): 4261-4263. doi: 10.1016/j.cclet.2022.03.003 shu

Octacyclic and decacyclic ent–abietane dimers with cytotoxic activity from Euphorbia fischeriana steud.

Yulin Peng ^{a, b, 1} ,
Yibo Chang ^{a, 1} ,
Chengpeng Sun ^{a, *,} ,
Weiyi Wang ^c ,
Chao Wang ^a ,
Yan Tian ^a ,
Baojing Zhang ^a ,
Sa Deng ^a ,
Wenyu Zhao ^{a, *,} ,
Xiaochi Ma ^{b, *,}

a.
College of Pharmacy, College of Integrative Medicine, Dalian Medical University, Dalian 116044, China
b.
Second Affiliated Hospital, Dalian Medical University, Dalian 116023, China
c.
Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, China

suncp146@163.com

wenyuzhao2019@163.com

maxc1978@163.com

Received Date: 6 December 2021
Revised Date: 24 February 2022
Accepted Date: 2 March 2022
Available Online: 4 March 2022

Figures(5)

A novel Diels-Alder adduct possesses a 6/6/6/5/6/6/6/6 octacyclic skeleton featured with bicyclo[2.2.2]octane moiety, biseupyiheoid A (1), along with another decacyclic 6/6/6/3/5/6/5/6/6/6 fused diterpenoid dimer, bisfischoid C (2), were isolated from Euphorbia fischeriana. Their structures were determined by spectroscopic, X-ray crystallographic approaches, and quantum mechanical calculations. The structural features of 1 and 2 were hypothesized to involve intramolecular Diels-Alder reactions with different coupling patterns. Dimer 1 showed antiproliferative activity through apoptosis activation in LoVo cells.
- Ditrpenoid dimers,
- Euphorbia fischeriana,
- ent-Abietanes,
- Diels-Alder adduct,
- Cytotoxic effect
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沈阳化工大学材料科学与工程学院沈阳 110142