Citation: Yingying Song, Chang-Ming Dong. Sugar-dependent targeting and immune adjuvant effects of hyperbranched glycosylated polypeptide nanoparticles for ovalbumin delivery[J]. Chinese Chemical Letters, ;2022, 33(8): 4084-4088. doi: 10.1016/j.cclet.2022.01.051 shu

Sugar-dependent targeting and immune adjuvant effects of hyperbranched glycosylated polypeptide nanoparticles for ovalbumin delivery

Yingying Song ,
Chang-Ming Dong ^*,

School of Chemistry and Chemical Engineering, Shanghai Key Laboratory of Electrical Insulation and Thermal Aging, Shanghai Jiao Tong University, Shanghai 200240, China

cmdong@sjtu.edu.cn

Received Date: 24 August 2021
Revised Date: 14 January 2022
Accepted Date: 17 January 2022
Available Online: 23 January 2022

Figures(4)

Sugar-dependent targeting and immune adjuvant effects of hyperbranched glycosylated polypeptide nanoparticles were disclosed for ovalbumin (OVA) delivery system. The mannose-coated polypeptide nanoparticles can induce strongest targeting and immune adjuvant effects to macrophages than those glucose/lactose-coated ones, which effectively transported OVA into cells and facilitated OVA subcellular escape from endolysosomes into cytoplasm with the assistance of UV irradiation or intracellular acidic pH.
- Polypeptide nanoparticles,
- Sugar targeting,
- Immune adjuvant,
- Ovalbumin delivery system
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