Citation: Yue Pan, Yao Xiao, Ying Hao, Kun Shi, Meng Pan, Zhiyong Qian. An injectable mPEG-PDLLA microsphere/PDLLA-PEG-PDLLA hydrogel composite for soft tissue augmentation[J]. Chinese Chemical Letters, ;2022, 33(5): 2486-2490. doi: 10.1016/j.cclet.2021.12.093 shu

An injectable mPEG-PDLLA microsphere/PDLLA-PEG-PDLLA hydrogel composite for soft tissue augmentation

State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China

zhiyongqian@scu.edu.cn

Received Date: 13 August 2021
Revised Date: 19 December 2021
Accepted Date: 31 December 2021
Available Online: 7 January 2022

Figures(5)

Injectable filling material is a simple and efficient method for soft tissues reconstruction and is extremely popular in not only plastic surgery but also cosmetic industry. However, there is a lack of soft tissue fillers with perfect performance on the market currently. Here, we constructed a new microsphere/hydrogel composite and evaluated its potential as a candidate for soft tissue augmentation. mPEG-PDLLA microspheres were prepared by utilizing a SPG membrane emulsifier which endowed microspheres with good sphericity and particle size uniformity. PDLLA-PEG-PDLLA hydrogel which shared the same component with the mPEG-PDLLA copolymer acted as a carrier and fixed the microspheres at the injected sites. The mPEG-PDLLA microsphere/PDLLA-PEG-PDLLA hydrogel composite was flowable in room temperature and transformed into gel after being heated to body temperature. This feature is convenient for subcutaneous filling. In vivo assessment on mice showed good safety profile of the composite. Moreover, the density of collagen fibers increased over 13 weeks. Overall, this biocompatible microsphere/hydrogel composite involves simple component and no extra crosslinking agents, and has the ability to stimulate collagen production, thus, may be a candidate for soft tissue augmentation.
- Soft tissue augmentation,
- mPEG-PDLLA,
- Microspheres,
- Hydrogel,
- Collagenogenesis
1. [1]
  J.J. Marler, A. Guha, J. Rowley, et al., Plast. Reconstr. Surg.105 (2000) 2049–2058. doi: 10.1097/00006534-200005000-00020
2. [2]
  S. Bosset, P. Barré, A. Chalon, et al., Eur. J. Dermatol. 12 (2002) 247–252.
3. [3]
  S.Z. Bai, Z.H. Feng, R. Gao, et al., Mil. Med. Res. 1 (2014) 11-11. doi: 10.1186/2054-9369-1-11
4. [4]
  C.W. Patrick, Anat. Rec. 263 (2001) 361–366. doi: 10.1002/ar.1113
5. [5]
  H.J. Park, J.S. Hwang, Y.S. Rho, et al., Korean J. Otolaryngol-Head Neck Surg. 47 (2004) 854–856.
6. [6]
  B. Tsoi, N.I. Ziolkowski, A. Thoma, et al., Plast. Reconstr. Surg. 133 (2014) 234–249. doi: 10.1097/01.prs.0000436847.94408.11
7. [7]
  B.J. Correa, W.M. Weathers, E.M. Wolfswinkel, et al., Semin. Plast. Surg. 27 (2013) 096–103. doi: 10.1055/s-0033-1351231
8. [8]
  M. Doornaert, J. Colle, E. De Maere, et al., Ann. Med. Surg. 37 (2019) 47–53. doi: 10.1016/j.amsu.2018.10.016
9. [9]
  H. Eto, H. Kato, H. Suga, et al., Plast. Reconstr. Surg. 129 (2012) 1081–1092. doi: 10.1097/PRS.0b013e31824a2b19
10. [10]
  A. Monfort, A. Izeta, J. Cosmet., Dermatol. Sci. Appl. 2 (2012) 93–107. doi: 10.4236/jcdsa.2012.222021
11. [11]
  P. Hedén, Aesthetic Plast. Surg. 44 (2020) 1295–1299. doi: 10.1007/s00266-020-01772-5
12. [12]
  Z.Y. Lin, V. Shah, A. Dhinakar, et al., Plast. Aesthet. Res. 3 (2016) 72–82. doi: 10.20517/2347-9264.2015.121
13. [13]
  W.I. Choi, Y. Hwang, A. Sahu, et al., Biomater. Sci. 6 (2018) 2627–2638. doi: 10.1039/c8bm00524a
14. [14]
  R. Dimatteo, N.J. Darling, T. Segura, Adv. Drug Deliv. Rev. 127 (2018) 167–184. doi: 10.1016/j.addr.2018.03.007
15. [15]
  L. Guiting, B. Ziting, W. Jun, Chin. Chem. Lett. 31 (2020) 1817–1821. doi: 10.1016/j.cclet.2020.03.005
16. [16]
  C. Liu, X. Liu, C. Liu, et al., Biomaterials 205 (2019) 23–37. doi: 10.1016/j.biomaterials.2019.03.016
17. [17]
  G. Xu, L. Cheng, Q. Zhang, et al., J. Biomater. Appl. 31 (2016) 721–729. doi: 10.1177/0885328216661557
18. [18]
  R.E. Jung, R. Zwahlen, F.E. Weber, et al., Clin. Oral Implants Res. 17 (2006) 426–433. doi: 10.1111/j.1600-0501.2005.01228.x
19. [19]
  H.K. Kim, W.S. Shim, S.E. Kim, et al., Tissue. Eng. Part A 15 (2009) 923–933. doi: 10.1089/ten.tea.2007.0407
20. [20]
  W. Xu, K. Liu, T. Li, et al., J. Biomed. Mater. Res. A 107 (2019) 742–754. doi: 10.1002/jbm.a.36589
21. [21]
  P. Tempesti, G.S. Nicotera, M. Bonini, et al., J. Colloid Interface Sci. 509 (2018) 123–131. doi: 10.1016/j.jcis.2017.09.001
22. [22]
  Y. Li, J. Rodrigues, H. Toms, Chem. Soc. Rev. 41 (2012) 2193–2221.
23. [23]
  C.F. Schierle, L.A. Casas, Aesthet. Surg. J. 31 (2011) 95–109. doi: 10.1177/1090820X10391213
24. [24]
  V. Lacombe, Facial Plast. Surg. 25 (2009) 095–099. doi: 10.1055/s-0029-1220648
25. [25]
  D.H. Jones, Dermatol. Clin. 27 (2009) 433–444. doi: 10.1016/j.det.2009.08.003
26. [26]
  P.J. Nicolau, Plast. Reconstr. Surg. 119 (2007) 2271–2286. doi: 10.1097/01.prs.0000260710.30934.a1
27. [27]
  T.C. Kontis, JAMA Facial Plast. Surg. 15 (2012) 1–7.
28. [28]
  R. Fitzgerald, D. Vleggaar, Dermatol. Ther. 24 (2011) 2–27. doi: 10.1111/j.1529-8019.2010.01375.x
29. [29]
  G. Zhou, H. Loppnow, T. Groth, Acta Biomater. 26 (2015) 54–63. doi: 10.1016/j.actbio.2015.08.020
30. [30]
  W.G. Brodbeck, M.S. Shive, E. Colton, et al., J. Biomed. Mater. Res. 55 (2001) 661–668. doi: 10.1002/1097-4636(20010615)55:4<661::AID-JBM1061>3.0.CO;2-F
31. [31]
  K. Shi, Y.L. Wang, Y. Qu, et al., Sci. Rep. 6 (2016) 19077. doi: 10.1038/srep19077
32. [32]
  S.S. Venkatraman, P. Jie, F. Min, et al., Int. J. Pharm. 298 (2005) 219–232. doi: 10.1016/j.ijpharm.2005.03.023
33. [33]
  I. Rashkov, N. Manolova, S.M. Li, et al., Macromolecules 29 (1996) 50–56. doi: 10.1021/ma950530t
34. [34]
  Y. Wei, Y. Wang, H. Zhang, et al., J. Colloid Interface Sci. 478 (2016) 46–53. doi: 10.1016/j.jcis.2016.05.045
35. [35]
  Y. Wei, Y. Wang, L. Wang, et al., Colloids Surf. B Biointerfaces 87 (2011) 399–408. doi: 10.1016/j.colsurfb.2011.05.051
36. [36]
  E. Lin, S.E. Calvano, S.F. Lowry, Surgery 127 (2000) 117–126. doi: 10.1067/msy.2000.101584
37. [37]
  C.X. Qiao, L. Hou, Z.L. Zhao, et al., China Med. Dev. Inform. 19 (2013) 61–65.
1. [1]
  Guo-Hua Zhang , Rui-Xia Hou , Dan-Xia Zhan , Yang Cong , Ya-Jun Cheng , Jun Fu . Fabrication of hollow porous PLGA microspheres for controlled protein release and promotion of cell compatibility. Chinese Chemical Letters, 2013, 24(8): 710-714.
2. [2]
  Yun Shen Chen , Ji Shuai Wang , Zhao Sheng Hou , Cheng You Kan . Preparation of polymeric microspheres with high content of sulphonate groups. Chinese Chemical Letters, 2010, 21(2): 234-236. doi: 10.1016/j.cclet.2009.08.016
3. [3]
  Nan Nan Geng , Cong Ming Xiao . Facile preparation of methylcellulose/poly(vinyl alcohol) physical complex hydrogels with tunable thermosensitivity. Chinese Chemical Letters, 2009, 20(1): 111-114. doi: 10.1016/j.cclet.2008.09.003
4. [4]
  Bing LIU , Zhi Lan LIU , Ren Xi ZHUO . Synthesis and Properties of IPN Hydrogels Based on Konjac Glucomannan and Poly(acrylic acid). Chinese Chemical Letters, 2006, 17(10): 1377-1380.
5. [5]
  Ma Fenqiang , Yao Jingwen , Zhang Yanfeng , Wei Yu . Oxygen vacancy promoting adsorption property of BiOI microspheres modified with SDS. Chinese Chemical Letters, 2018, 29(11): 1689-1691. doi: 10.1016/j.cclet.2017.12.016
6. [6]
  Cai Hua NI , Xian Yu ZENG , He HUANG . Synthesis and Swelling Properties of Thermosensitive Hydrogels based on Terpolymerization. Chinese Chemical Letters, 2005, 16(5): 675-676.
7. [7]
  Yuting Wang , Shu Zhang , Jian Wang . Photo-crosslinkable hydrogel and its biological applications. Chinese Chemical Letters, 2021, 32(5): 1603-1614. doi: 10.1016/j.cclet.2020.11.073
8. [8]
  Xiong Wei , Zhou Hantao , Zhang Chong , Lu Hua . An amino acid-based gelator for injectable and multi-responsive hydrogel. Chinese Chemical Letters, 2017, 28(11): 2125-2128. doi: 10.1016/j.cclet.2017.09.019
9. [9]
  Chenglong Cai , Ting Wang , Xu Han , Shaoqiang Yang , Chengteng Lai , Tao Yuan , Zhangqi Feng , Nongyue He . In situ wound sprayable double-network hydrogel: Preparation and characterization. Chinese Chemical Letters, 2022, 33(4): 1963-1969. doi: 10.1016/j.cclet.2021.11.047
10. [10]
  Zhao Qian , Chen Yong , Liu Yu . A polysaccharide/tetraphenylethylene-mediated blue-light emissive and injectable supramolecular hydrogel. Chinese Chemical Letters, 2018, 29(1): 84-86. doi: 10.1016/j.cclet.2017.07.024
11. [11]
  Liu Guiting , Bao Ziting , Wu Jun . Injectable baicalin/F127 hydrogel with antioxidant activity for enhanced wound healing. Chinese Chemical Letters, 2020, 31(7): 1817-1821. doi: 10.1016/j.cclet.2020.03.005
12. [12]
  Wei Yuan , Xinyu Qu , Yao Lu , Wen Zhao , Yanfang Ren , Qian Wang , Wenjun Wang , Xiaochen Dong . MXene-composited highly stretchable, sensitive and durable hydrogel for flexible strain sensors. Chinese Chemical Letters, 2021, 32(6): 2021-2026. doi: 10.1016/j.cclet.2020.12.003
13. [13]
  Shaohua Zhang , Hang Zhou , Chang Huang , Jianguo Sun , Xue Qu , Yi Lu . A novel corneal adhesive based on functionally coupled PEG-lysozyme hydrogel for wound closure after surgical eye surgery. Chinese Chemical Letters, 2022, 33(9): 4321-4325. doi: 10.1016/j.cclet.2022.01.024
14. [14]
  Yike Li , Huiyu Zheng , Yaxian Liang , Ming Xuan , Guiting Liu , Huixu Xie . Hyaluronic acid-methacrylic anhydride/polyhexamethylene biguanide hybrid hydrogel with antibacterial and proangiogenic functions for diabetic wound repair. Chinese Chemical Letters, 2022, 33(12): 5030-5034. doi: 10.1016/j.cclet.2022.03.116
15. [15]
  Tian Bai , Kongyin Zhao , Zijie Lu , Xuefang Liu , Ze Lin , Mengmeng Cheng , Ziyi Li , Dunwan Zhu , Linhua Zhang . Simple fabrication of Cu²⁺ doped calcium alginate hydrogel filtration membrane with excellent anti-fouling and antibacterial properties. Chinese Chemical Letters, 2021, 32(3): 1051-1054. doi: 10.1016/j.cclet.2020.07.034

Get Citation

PDF

XML

Metrics

PDF Downloads(5)
Abstract views(248)
HTML views(83)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142